| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,963,301 | 60,110,000 | 21.18% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 3,124,480 | 31,495,000 | 11.10% | ||
| 3 | BRIDGER MANAGEMENT, LLC | 3,053,916 | 30,783,000 | 10.85% | ||
| 4 | STATE STREET CORP | 2,635,023 | 26,560,000 | 9.36% | ||
| 5 | BAKER BROS. ADVISORS LP | 2,003,991 | 20,200,000 | 7.12% | ||
| 6 | SECTORAL ASSET MANAGEMENT INC | 1,464,105 | 14,758,000 | 5.20% | ||
| 7 | VANGUARD GROUP INC | 1,222,023 | 12,318,000 | 4.34% | ||
| 8 | BlackRock Fund Advisors | 932,054 | 9,395,000 | 3.31% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 868,096 | 8,750,000 | 3.08% | ||
| 10 | COLUMBUS CIRCLE INVESTORS | 661,199 | 6,665,000 | 2.35% | ||
| 11 | Visium Asset Management, LP | 500,000 | 5,040,000 | 1.78% | ||
| 12 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 443,400 | 4,469,000 | 1.57% | ||
| 13 | EDMOND DE ROTHSCHILD HOLDING S.A. | 443,400 | 4,469,000 | 1.57% | ||
| 14 | NORTHERN TRUST CORP | 426,363 | 4,298,000 | 1.51% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 375,800 | 3,788,000 | 1.33% | ||
| 16 | Candriam S.C.A. | 261,200 | 2,633,000 | 0.93% | ||
| 17 | Opaleye Management Inc. | 260,000 | 2,621,000 | 0.92% | ||
| 18 | STONERIDGE INVESTMENT PARTNERS LLC | 255,397 | 2,574,000 | 0.91% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 247,616 | 2,495,000 | 0.88% | ||
| 20 | LORD, ABBETT & CO. LLC | 234,829 | 2,367,000 | 0.83% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 185,200 | 1,867,000 | 0.66% | ||
| 22 | NEW YORK STATE COMMON RETIREMENT FUND | 180,918 | 1,824,000 | 0.64% | ||
| 23 | Bank of New York Mellon Corp | 170,183 | 1,715,000 | 0.60% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 155,730 | 1,570,000 | 0.55% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 152,546 | 1,538,000 | 0.54% | ||
| 26 | DEUTSCHE BANK AG\ | 151,844 | 1,530,000 | 0.54% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 140,700 | 1,418,000 | 0.50% | ||
| 28 | BlackRock Investment Management, LLC | 123,886 | 1,249,000 | 0.44% | ||
| 29 | GUGGENHEIM CAPITAL LLC | 118,354 | 1,193,000 | 0.42% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 117,795 | 1,187,000 | 0.42% | ||
| 31 | GROUP ONE TRADING LLC | 98,317 | 991,000 | 0.35% | ||
| 32 | FRED ALGER MANAGEMENT, LLC | 80,450 | 811,000 | 0.29% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,353 | 649,000 | 0.23% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 59,050 | 596,000 | 0.21% | ||
| 35 | MORGAN STANLEY | 57,925 | 583,000 | 0.21% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,500 | 539,000 | 0.19% | Call | |
| 37 | AQR CAPITAL MANAGEMENT LLC | 53,123 | 535,000 | 0.19% | ||
| 38 | TEACHERS ADVISORS, LLC | 51,682 | 521,000 | 0.18% | ||
| 39 | Weiss Multi-Strategy Advisers LLC | 51,000 | 514,000 | 0.18% | ||
| 40 | HAP Trading, LLC | 50,326 | 507,000 | 0.18% | ||
| 41 | ALLIANCEBERNSTEIN L.P. | 50,040 | 504,000 | 0.18% | ||
| 42 | Swiss National Bank | 45,600 | 460,000 | 0.16% | ||
| 43 | CITIGROUP INC | 40,352 | 407,000 | 0.14% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,100 | 374,000 | 0.13% | Put | |
| 45 | Creative Planning | 34,248 | 345,000 | 0.12% | ||
| 46 | Virtu KCG Holdings LLC | 33,968 | 342,000 | 0.12% | ||
| 47 | RHUMBLINE ADVISERS | 32,005 | 323,000 | 0.11% | ||
| 48 | PEAK6 Group LLC | 30,000 | 302,000 | 0.11% | Call | |
| 49 | METROPOLITAN LIFE INSURANCE CO/NY | 25,432 | 256,000 | 0.09% | ||
| 50 | BLACKROCK ADVISORS LLC | 23,373 | 236,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
