| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 3,125,149 | 48,377,000 | 14.37% | ||
| 2 | FMR LLC | 3,061,070 | 47,385,000 | 14.07% | ||
| 3 | BRIDGER MANAGEMENT, LLC | 2,051,821 | 31,762,000 | 9.43% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,050,313 | 31,739,000 | 9.43% | ||
| 5 | STATE STREET CORP | 1,667,684 | 25,820,000 | 7.67% | ||
| 6 | Visium Asset Management, LP | 1,301,500 | 20,147,000 | 5.98% | ||
| 7 | VANGUARD GROUP INC | 1,066,992 | 16,517,000 | 4.91% | ||
| 8 | BlackRock Fund Advisors | 809,701 | 12,534,000 | 3.72% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 733,602 | 11,356,000 | 3.37% | ||
| 10 | COLUMBUS CIRCLE INVESTORS | 461,399 | 7,142,000 | 2.12% | ||
| 11 | SECTORAL ASSET MANAGEMENT INC | 436,084 | 6,751,000 | 2.00% | ||
| 12 | Informed Momentum Co LLC | 401,875 | 6,221,000 | 1.85% | ||
| 13 | Candriam S.C.A. | 330,000 | 5,110,000 | 1.52% | ||
| 14 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 325,000 | 5,031,000 | 1.49% | ||
| 15 | STONERIDGE INVESTMENT PARTNERS LLC | 308,744 | 4,779,000 | 1.42% | ||
| 16 | NORTHERN TRUST CORP | 307,203 | 4,756,000 | 1.41% | ||
| 17 | NEW YORK STATE COMMON RETIREMENT FUND | 258,789 | 4,006,000 | 1.19% | ||
| 18 | Bank of New York Mellon Corp | 224,052 | 3,468,000 | 1.03% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 193,698 | 2,998,000 | 0.89% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 183,000 | 2,833,000 | 0.84% | ||
| 21 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,800 | 2,343,000 | 0.70% | ||
| 22 | GRATICULE ASIA MACRO ADVISORS LLC | 150,000 | 2,321,000 | 0.69% | Call | |
| 23 | DEUTSCHE BANK AG\ | 124,517 | 1,926,000 | 0.57% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 122,100 | 1,890,000 | 0.56% | Put | |
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 119,100 | 1,844,000 | 0.55% | Call | |
| 26 | RUSSELL FRANK CO/ | 115,121 | 1,782,000 | 0.53% | ||
| 27 | Invesco Ltd. | 108,486 | 1,679,000 | 0.50% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,796 | 1,638,000 | 0.49% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 86,940 | 1,346,000 | 0.40% | ||
| 30 | BlackRock Investment Management, LLC | 84,061 | 1,301,000 | 0.39% | ||
| 31 | Sio Capital Management, LLC | 76,924 | 1,191,000 | 0.35% | ||
| 32 | MORGAN STANLEY | 74,927 | 1,161,000 | 0.34% | ||
| 33 | FRED ALGER MANAGEMENT, LLC | 73,000 | 1,130,000 | 0.34% | ||
| 34 | AMERIPRISE FINANCIAL INC | 72,069 | 1,116,000 | 0.33% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 67,977 | 1,052,000 | 0.31% | ||
| 36 | CITADEL ADVISORS LLC | 63,697 | 986,000 | 0.29% | ||
| 37 | D. E. Shaw & Co., Inc. | 61,346 | 950,000 | 0.28% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,991 | 820,000 | 0.24% | ||
| 39 | AQR CAPITAL MANAGEMENT LLC | 49,500 | 766,000 | 0.23% | ||
| 40 | PICTET ASSET MANAGEMENT LTD | 49,300 | 688,000 | 0.20% | ||
| 41 | DRIEHAUS CAPITAL MANAGEMENT LLC | 42,521 | 658,000 | 0.20% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,100 | 637,000 | 0.19% | ||
| 43 | Weiss Multi-Strategy Advisers LLC | 40,000 | 619,000 | 0.18% | ||
| 44 | TEACHERS ADVISORS, LLC | 38,565 | 597,000 | 0.18% | ||
| 45 | GROUP ONE TRADING LLC | 35,720 | 553,000 | 0.16% | ||
| 46 | Swiss National Bank | 34,900 | 540,000 | 0.16% | ||
| 47 | HAP Trading, LLC | 31,582 | 489,000 | 0.15% | ||
| 48 | RHUMBLINE ADVISERS | 26,654 | 413,000 | 0.12% | ||
| 49 | CREDIT SUISSE AG/ | 25,893 | 401,000 | 0.12% | ||
| 50 | GOLDMAN SACHS GROUP INC | 25,552 | 396,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
