| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | RA CAPITAL MANAGEMENT, L.P. | 3,350,449 | 53,071,000 | 17.70% | ||
| 2 | BAKER BROS. ADVISORS LP | 2,050,313 | 32,477,000 | 10.83% | ||
| 3 | FMR LLC | 1,927,803 | 30,536,000 | 10.19% | ||
| 4 | BRIDGER MANAGEMENT, LLC | 1,780,538 | 28,204,000 | 9.41% | ||
| 5 | Visium Asset Management, LP | 1,200,000 | 19,008,000 | 6.34% | ||
| 6 | VANGUARD GROUP INC | 1,046,968 | 16,584,000 | 5.53% | ||
| 7 | JPMORGAN CHASE & CO | 798,361 | 12,646,000 | 4.22% | ||
| 8 | BlackRock Fund Advisors | 763,724 | 12,097,000 | 4.04% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 514,441 | 8,149,000 | 2.72% | ||
| 10 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 431,200 | 6,830,000 | 2.28% | Call | |
| 11 | Informed Momentum Co LLC | 430,627 | 6,821,000 | 2.28% | ||
| 12 | Candriam S.C.A. | 380,000 | 6,019,000 | 2.01% | ||
| 13 | STATE STREET CORP | 355,916 | 5,639,000 | 1.88% | ||
| 14 | NORTHERN TRUST CORP | 300,491 | 4,759,000 | 1.59% | ||
| 15 | STONERIDGE INVESTMENT PARTNERS LLC | 230,525 | 3,652,000 | 1.22% | ||
| 16 | COLUMBUS CIRCLE INVESTORS | 229,731 | 3,639,000 | 1.21% | ||
| 17 | Bank of New York Mellon Corp | 228,814 | 3,624,000 | 1.21% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 183,886 | 2,912,000 | 0.97% | ||
| 19 | BARCLAYS PLC | 183,551 | 2,753,000 | 0.92% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 157,881 | 2,501,000 | 0.83% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 155,000 | 2,455,000 | 0.82% | ||
| 22 | EverPoint Asset Management, LLC | 154,689 | 2,450,000 | 0.82% | ||
| 23 | RUSSELL FRANK CO/ | 154,690 | 2,438,000 | 0.81% | ||
| 24 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 149,800 | 2,343,000 | 0.78% | ||
| 25 | NEW YORK STATE COMMON RETIREMENT FUND | 145,180 | 2,300,000 | 0.77% | ||
| 26 | Sio Capital Management, LLC | 102,700 | 1,627,000 | 0.54% | ||
| 27 | AMERIPRISE FINANCIAL INC | 99,464 | 1,576,000 | 0.53% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 92,959 | 1,472,000 | 0.49% | ||
| 29 | Invesco Ltd. | 89,681 | 1,421,000 | 0.47% | ||
| 30 | MOODY NATIONAL BANK TRUST DIVISION | 84,149 | 1,333,000 | 0.44% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 80,610 | 1,277,000 | 0.43% | ||
| 32 | BlackRock Investment Management, LLC | 78,034 | 1,236,000 | 0.41% | ||
| 33 | Jefferies Group LLC | 75,000 | 1,188,000 | 0.40% | Put | |
| 34 | DEUTSCHE BANK AG\ | 72,989 | 1,155,000 | 0.39% | ||
| 35 | MORGAN STANLEY | 70,172 | 1,112,000 | 0.37% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 64,300 | 1,019,000 | 0.34% | Call | |
| 37 | A.R.T. Advisors, LLC | 58,245 | 922,000 | 0.31% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 51,091 | 809,000 | 0.27% | ||
| 39 | AQR CAPITAL MANAGEMENT LLC | 48,400 | 767,000 | 0.26% | ||
| 40 | CREDIT SUISSE AG/ | 45,019 | 713,000 | 0.24% | ||
| 41 | Weiss Multi-Strategy Advisers LLC | 36,000 | 570,000 | 0.19% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 34,400 | 545,000 | 0.18% | ||
| 43 | DEERE & CO | 33,089 | 524,000 | 0.17% | ||
| 44 | TEACHERS ADVISORS, LLC | 32,928 | 522,000 | 0.17% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,900 | 474,000 | 0.16% | Put | |
| 46 | DRIEHAUS CAPITAL MANAGEMENT LLC | 28,700 | 455,000 | 0.15% | ||
| 47 | Creative Planning | 24,800 | 393,000 | 0.13% | ||
| 48 | Swiss National Bank | 24,300 | 385,000 | 0.13% | ||
| 49 | Nationwide Fund Advisors | 20,725 | 328,000 | 0.11% | ||
| 50 | RHUMBLINE ADVISERS | 20,459 | 324,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
