| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,874,842 | 64,284,000 | 16.05% | ||
| 2 | RA CAPITAL MANAGEMENT, L.P. | 3,302,213 | 54,784,000 | 13.68% | ||
| 3 | STATE STREET CORP | 2,092,249 | 34,711,000 | 8.67% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,003,991 | 33,246,000 | 8.30% | ||
| 5 | BRIDGER MANAGEMENT, LLC | 1,537,529 | 25,508,000 | 6.37% | ||
| 6 | VANGUARD GROUP INC | 1,097,494 | 18,208,000 | 4.55% | ||
| 7 | BlackRock Fund Advisors | 930,330 | 15,434,000 | 3.85% | ||
| 8 | SECTORAL ASSET MANAGEMENT INC | 772,017 | 12,808,000 | 3.20% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 743,106 | 12,328,000 | 3.08% | ||
| 10 | Visium Asset Management, LP | 530,000 | 8,793,000 | 2.20% | ||
| 11 | EDMOND DE ROTHSCHILD (SUISSE) S.A. | 525,068 | 8,711,000 | 2.18% | ||
| 12 | EDMOND DE ROTHSCHILD HOLDING S.A. | 525,068 | 8,711,000 | 2.18% | ||
| 13 | COLUMBUS CIRCLE INVESTORS | 465,180 | 7,717,000 | 1.93% | ||
| 14 | Informed Momentum Co LLC | 410,689 | 6,813,000 | 1.70% | ||
| 15 | LORD, ABBETT & CO. LLC | 393,308 | 6,525,000 | 1.63% | ||
| 16 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 380,100 | 6,306,000 | 1.57% | ||
| 17 | NORTHERN TRUST CORP | 360,640 | 5,982,000 | 1.49% | ||
| 18 | Candriam S.C.A. | 300,000 | 4,977,000 | 1.24% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 271,100 | 4,498,000 | 1.12% | ||
| 20 | STONERIDGE INVESTMENT PARTNERS LLC | 257,335 | 4,269,000 | 1.07% | ||
| 21 | Bank of New York Mellon Corp | 255,485 | 4,239,000 | 1.06% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 244,720 | 4,059,000 | 1.01% | ||
| 23 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 185,200 | 3,072,000 | 0.77% | ||
| 24 | NEW YORK STATE COMMON RETIREMENT FUND | 183,168 | 3,039,000 | 0.76% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,800 | 2,485,000 | 0.62% | Call | |
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 133,121 | 2,208,000 | 0.55% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 128,600 | 2,133,000 | 0.53% | Put | |
| 28 | BlackRock Investment Management, LLC | 125,443 | 2,081,000 | 0.52% | ||
| 29 | RUSSELL FRANK CO/ | 119,079 | 1,976,000 | 0.49% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 117,795 | 1,954,000 | 0.49% | ||
| 31 | AMERIPRISE FINANCIAL INC | 97,285 | 1,614,000 | 0.40% | ||
| 32 | DEUTSCHE BANK AG\ | 83,443 | 1,383,000 | 0.35% | ||
| 33 | D. E. Shaw & Co., Inc. | 81,342 | 1,349,000 | 0.34% | ||
| 34 | CREDIT SUISSE AG/ | 81,158 | 1,346,000 | 0.34% | ||
| 35 | FRED ALGER MANAGEMENT, LLC | 80,450 | 1,335,000 | 0.33% | ||
| 36 | PICTET ASSET MANAGEMENT LTD | 69,400 | 1,211,000 | 0.30% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,553 | 1,071,000 | 0.27% | ||
| 38 | AQR CAPITAL MANAGEMENT LLC | 63,060 | 1,046,000 | 0.26% | ||
| 39 | GROUP ONE TRADING LLC | 60,934 | 1,011,000 | 0.25% | ||
| 40 | MORGAN STANLEY | 59,540 | 988,000 | 0.25% | ||
| 41 | TEACHERS ADVISORS, LLC | 51,682 | 857,000 | 0.21% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 50,200 | 833,000 | 0.21% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 49,750 | 826,000 | 0.21% | ||
| 44 | HAP Trading, LLC | 45,883 | 761,000 | 0.19% | ||
| 45 | GOLDMAN SACHS GROUP INC | 43,053 | 714,000 | 0.18% | ||
| 46 | CITADEL ADVISORS LLC | 36,307 | 602,000 | 0.15% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 36,129 | 599,000 | 0.15% | ||
| 48 | Swiss National Bank | 34,900 | 579,000 | 0.14% | ||
| 49 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 33,808 | 561,000 | 0.14% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 33,587 | 557,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
