| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | QVT Financial LP | 16,013,540 | 97,522,000 | 45.79% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 2,838,000 | 17,283,000 | 8.12% | ||
| 3 | Alpha Wave Global, LP | 2,618,000 | 15,944,000 | 7.49% | ||
| 4 | HealthCor Management, L.P. | 2,150,000 | 13,094,000 | 6.15% | ||
| 5 | FRANKLIN RESOURCES INC | 2,056,300 | 12,523,000 | 5.88% | ||
| 6 | D. E. Shaw & Co., Inc. | 1,857,076 | 11,310,000 | 5.31% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 1,355,839 | 8,257,000 | 3.88% | ||
| 8 | AXA S.A. | 797,719 | 4,858,000 | 2.28% | ||
| 9 | CITADEL ADVISORS LLC | 754,630 | 4,596,000 | 2.16% | ||
| 10 | SABBY MANAGEMENT, LLC | 725,007 | 4,415,000 | 2.07% | ||
| 11 | GOLDMAN SACHS GROUP INC | 704,585 | 4,291,000 | 2.01% | ||
| 12 | SPHERA FUNDS MANAGEMENT LTD. | 505,000 | 3,075,000 | 1.44% | ||
| 13 | SUFFOLK CAPITAL MANAGEMENT LLC | 233,094 | 1,420,000 | 0.67% | ||
| 14 | BAILARD, INC. | 215,000 | 1,309,000 | 0.61% | ||
| 15 | MARINER INVESTMENT GROUP LLC | 201,100 | 1,225,000 | 0.58% | ||
| 16 | CREDIT SUISSE AG/ | 181,652 | 1,107,000 | 0.52% | ||
| 17 | BAKER BROS. ADVISORS LP | 180,582 | 1,100,000 | 0.52% | ||
| 18 | Candriam S.C.A. | 167,600 | 1,021,000 | 0.48% | ||
| 19 | DEUTSCHE BANK AG\ | 152,400 | 927,000 | 0.44% | ||
| 20 | MORGAN STANLEY | 127,038 | 774,000 | 0.36% | ||
| 21 | BELLEVUE ASSET MANAGEMENT AG | 125,000 | 761,000 | 0.36% | ||
| 22 | RENAISSANCE TECHNOLOGIES LLC | 110,100 | 671,000 | 0.32% | ||
| 23 | GROUP ONE TRADING LLC | 78,553 | 478,000 | 0.22% | ||
| 24 | SIT INVESTMENT ASSOCIATES INC | 71,200 | 434,000 | 0.20% | ||
| 25 | ROYAL BANK OF CANADA | 70,300 | 428,000 | 0.20% | ||
| 26 | Telemetry Investments, L.L.C. | 62,360 | 380,000 | 0.18% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,300 | 325,000 | 0.15% | Call | |
| 28 | Trexquant Investment LP | 51,500 | 313,000 | 0.15% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,500 | 265,000 | 0.12% | Put | |
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,482 | 253,000 | 0.12% | ||
| 31 | MACKENZIE FINANCIAL CORP | 39,900 | 243,000 | 0.11% | ||
| 32 | K2 PRINCIPAL FUND, L.P. | 37,135 | 226,000 | 0.11% | ||
| 33 | STATE STREET CORP | 34,258 | 208,000 | 0.10% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 33,069 | 201,000 | 0.09% | ||
| 35 | Visium Asset Management, LP | 31,700 | 193,000 | 0.09% | ||
| 36 | AMERIPRISE FINANCIAL INC | 28,541 | 174,000 | 0.08% | ||
| 37 | Stanley-Laman Group, Ltd. | 25,722 | 157,000 | 0.07% | ||
| 38 | JANE STREET GROUP, LLC | 25,374 | 155,000 | 0.07% | ||
| 39 | Anson Funds Management LP | 25,000 | 152,000 | 0.07% | ||
| 40 | A.R.T. Advisors, LLC | 22,617 | 137,000 | 0.06% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 20,060 | 122,000 | 0.06% | ||
| 42 | Airain ltd | 19,135 | 117,000 | 0.05% | ||
| 43 | CITIGROUP INC | 17,032 | 103,000 | 0.05% | ||
| 44 | CITIGROUP INC | 16,100 | 98,000 | 0.05% | Call | |
| 45 | FMR LLC | 11,600 | 71,000 | 0.03% | ||
| 46 | NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 9,934 | 60,000 | 0.03% | ||
| 47 | UBS Group AG | 7,512 | 46,000 | 0.02% | ||
| 48 | SIMPLEX TRADING, LLC | 5,293 | 32,000 | 0.02% | ||
| 49 | Tower Research Capital LLC (TRC) | 5,300 | 32,000 | 0.02% | ||
| 50 | Global X Management CO LLC | 5,134 | 31,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
