| 1 |
Essex Woodlands Management, Inc. |
1,179,352 |
1,824,000 |
28.86% |
|
|
| 2 |
BVF INC/IL |
970,948 |
1,476,000 |
23.35% |
|
|
| 3 |
NEA Management Company, LLC |
652,380 |
992,000 |
15.70% |
|
|
| 4 |
UBS Group AG |
353,749 |
538,000 |
8.51% |
|
|
| 5 |
VANGUARD GROUP INC |
241,112 |
367,000 |
5.81% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
161,419 |
245,000 |
3.88% |
|
|
| 7 |
RENAISSANCE TECHNOLOGIES LLC |
102,650 |
156,000 |
2.47% |
|
|
| 8 |
COLORADO CAPITAL MANAGEMENT, INC. |
78,375 |
120,000 |
1.90% |
|
|
| 9 |
DAFNA Capital Management LLC |
70,903 |
108,000 |
1.71% |
|
|
| 10 |
DIMENSIONAL FUND ADVISORS LP |
61,870 |
94,000 |
1.49% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
50,523 |
77,000 |
1.22% |
|
|
| 12 |
DG Capital Management, LLC |
45,265 |
69,000 |
1.09% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
25,666 |
39,000 |
0.62% |
|
|
| 14 |
PRICE T ROWE ASSOCIATES INC /MD/ |
24,669 |
37,000 |
0.59% |
|
|
| 15 |
NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC |
23,099 |
35,000 |
0.55% |
|
|
| 16 |
Bank of New York Mellon Corp |
21,321 |
32,000 |
0.51% |
|
|
| 17 |
Arbor Investment Advisors, LLC |
14,751 |
22,000 |
0.35% |
|
|
| 18 |
MORGAN STANLEY |
13,626 |
21,000 |
0.33% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
13,428 |
20,000 |
0.32% |
|
|
| 20 |
WEDBUSH SECURITIES INC |
13,475 |
20,000 |
0.32% |
|
|
| 21 |
WOLVERINE TRADING LP /BD |
5,050 |
6,313 |
0.10% |
|
|
| 22 |
WOLVERINE TRADING LP /BD |
47 |
5,875 |
0.09% |
Put |
|
| 23 |
GROUP ONE TRADING LLC |
2,679 |
4,000 |
0.06% |
|
|
| 24 |
BlackRock Japan Co. Ltd |
2,169 |
3,000 |
0.05% |
|
|
| 25 |
DEUTSCHE BANK AG\ |
1,535 |
2,000 |
0.03% |
|
|
| 26 |
Nationwide Fund Advisors |
1,328 |
2,000 |
0.03% |
|
|
| 27 |
BlackRock Fund Advisors |
626 |
1,000 |
0.02% |
|
|
| 28 |
PANAGORA ASSET MANAGEMENT INC |
899 |
1,000 |
0.02% |
|
|
| 29 |
WOLVERINE TRADING LP /BD |
8 |
1,000 |
0.02% |
Call |
|
| 30 |
BLACKROCK ADVISORS LLC |
579 |
1,000 |
0.02% |
|
|
| 31 |
Tower Research Capital LLC (TRC) |
469 |
1,000 |
0.02% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
45 |
0 |
0.00% |
|
|
| 33 |
ROYAL BANK OF CANADA |
174 |
0 |
0.00% |
|
|
| 34 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
178 |
0 |
0.00% |
|
|
| 35 |
WELLS FARGO & COMPANY/MN |
28 |
0 |
0.00% |
|
|
