| 1 |
Essex Woodlands Management, Inc. |
1,179,352 |
5,658,000 |
24.61% |
|
|
| 2 |
BVF INC/IL |
1,020,874 |
4,757,000 |
20.69% |
|
|
| 3 |
NEA Management Company, LLC |
652,380 |
3,040,000 |
13.22% |
|
|
| 4 |
RTW INVESTMENTS, LP |
380,806 |
1,775,000 |
7.72% |
|
|
| 5 |
DG Capital Management, LLC |
255,819 |
1,192,000 |
5.19% |
|
|
| 6 |
VANGUARD GROUP INC |
210,227 |
980,000 |
4.26% |
|
|
| 7 |
Camber Capital Management LP |
192,935 |
899,000 |
3.91% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
165,291 |
770,000 |
3.35% |
|
|
| 9 |
D. E. Shaw & Co., Inc. |
106,160 |
495,000 |
2.15% |
|
|
| 10 |
Sarissa Capital Management LP |
90,000 |
419,000 |
1.82% |
|
|
| 11 |
Avoro Capital Advisors LLC |
83,901 |
391,000 |
1.70% |
|
|
| 12 |
DAFNA Capital Management LLC |
70,903 |
330,000 |
1.44% |
|
|
| 13 |
DIMENSIONAL FUND ADVISORS LP |
67,174 |
313,000 |
1.36% |
|
|
| 14 |
GOLDMAN SACHS GROUP INC |
64,166 |
299,000 |
1.30% |
|
|
| 15 |
RENAISSANCE TECHNOLOGIES LLC |
62,433 |
291,000 |
1.27% |
|
|
| 16 |
EcoR1 Capital, LLC |
56,000 |
261,000 |
1.14% |
|
|
| 17 |
FMR LLC |
39,417 |
184,000 |
0.80% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
27,700 |
129,000 |
0.56% |
Call |
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
25,656 |
119,000 |
0.52% |
|
|
| 20 |
Spark Investment Management LLC |
20,300 |
94,000 |
0.41% |
|
|
| 21 |
Bank of New York Mellon Corp |
18,582 |
86,000 |
0.37% |
|
|
| 22 |
MORGAN STANLEY |
18,113 |
84,000 |
0.37% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
15,568 |
72,000 |
0.31% |
|
|
| 24 |
Arbor Investment Advisors, LLC |
14,751 |
69,000 |
0.30% |
|
|
| 25 |
Connor, Clark & Lunn Investment Management Ltd. |
14,683 |
68,000 |
0.30% |
|
|
| 26 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
13,428 |
63,000 |
0.27% |
|
|
| 27 |
BlackRock Fund Advisors |
10,575 |
49,000 |
0.21% |
|
|
| 28 |
ROYAL BANK OF CANADA |
7,699 |
36,000 |
0.16% |
|
|
| 29 |
BANK OF AMERICA CORP /DE/ |
5,395 |
26,000 |
0.11% |
|
|
| 30 |
BlackRock Japan Co. Ltd |
2,662 |
12,000 |
0.05% |
|
|
| 31 |
Tower Research Capital LLC (TRC) |
2,055 |
9,000 |
0.04% |
|
|
| 32 |
Nationwide Fund Advisors |
1,328 |
6,000 |
0.03% |
|
|
| 33 |
BlackRock Investment Management, LLC |
923 |
4,000 |
0.02% |
|
|
| 34 |
PANAGORA ASSET MANAGEMENT INC |
899 |
4,000 |
0.02% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
617 |
3,000 |
0.01% |
|
|
| 36 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
178 |
1,000 |
0.00% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
1 |
0 |
0.00% |
|
|
| 38 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
71 |
0 |
0.00% |
|
|
| 39 |
Shamrock Asset Management LLC |
57 |
0 |
0.00% |
|
|
| 40 |
GLENMEDE TRUST CO NA |
89 |
0 |
0.00% |
|
|
