| 1 |
Essex Woodlands Management, Inc. |
1,179,352 |
2,017,000 |
27.54% |
|
|
| 2 |
BVF INC/IL |
970,948 |
1,631,000 |
22.27% |
|
|
| 3 |
NEA Management Company, LLC |
652,380 |
1,096,000 |
14.96% |
|
|
| 4 |
UBS Group AG |
353,763 |
594,000 |
8.11% |
|
|
| 5 |
VANGUARD GROUP INC |
241,112 |
405,000 |
5.53% |
|
|
| 6 |
BlackRock Institutional Trust Company, N.A. |
162,111 |
272,000 |
3.71% |
|
|
| 7 |
DG Capital Management, LLC |
155,352 |
261,000 |
3.56% |
|
|
| 8 |
COLORADO CAPITAL MANAGEMENT, INC. |
78,375 |
131,000 |
1.79% |
|
|
| 9 |
Avoro Capital Advisors LLC |
71,500 |
120,000 |
1.64% |
|
|
| 10 |
DAFNA Capital Management LLC |
70,903 |
119,000 |
1.62% |
|
|
| 11 |
DIMENSIONAL FUND ADVISORS LP |
66,480 |
112,000 |
1.53% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
66,550 |
112,000 |
1.53% |
|
|
| 13 |
GOLDMAN SACHS GROUP INC |
49,369 |
83,000 |
1.13% |
|
|
| 14 |
D. E. Shaw & Co., Inc. |
40,036 |
67,000 |
0.91% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
25,666 |
43,000 |
0.59% |
|
|
| 16 |
PRICE T ROWE ASSOCIATES INC /MD/ |
24,669 |
41,000 |
0.56% |
|
|
| 17 |
NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC |
23,099 |
39,000 |
0.53% |
|
|
| 18 |
Spark Investment Management LLC |
19,151 |
32,000 |
0.44% |
|
|
| 19 |
Bank of New York Mellon Corp |
18,501 |
31,000 |
0.42% |
|
|
| 20 |
Arbor Investment Advisors, LLC |
14,751 |
25,000 |
0.34% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
14,000 |
24,000 |
0.33% |
Call |
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
13,428 |
23,000 |
0.31% |
|
|
| 23 |
BlackRock Fund Advisors |
10,056 |
17,000 |
0.23% |
|
|
| 24 |
MORGAN STANLEY |
10,119 |
17,000 |
0.23% |
|
|
| 25 |
BlackRock Japan Co. Ltd |
2,268 |
4,000 |
0.05% |
|
|
| 26 |
BlackRock Investment Management, LLC |
923 |
2,000 |
0.03% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
1,535 |
2,000 |
0.03% |
|
|
| 28 |
Nationwide Fund Advisors |
1,328 |
2,000 |
0.03% |
|
|
| 29 |
PANAGORA ASSET MANAGEMENT INC |
899 |
2,000 |
0.03% |
|
|
| 30 |
BLACKROCK ADVISORS LLC |
579 |
1,000 |
0.01% |
|
|
| 31 |
Shamrock Asset Management LLC |
57 |
0 |
0.00% |
|
|
| 32 |
WELLS FARGO & COMPANY/MN |
1 |
0 |
0.00% |
|
|
| 33 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
178 |
0 |
0.00% |
|
|
| 34 |
Tower Research Capital LLC (TRC) |
55 |
0 |
0.00% |
|
|
| 35 |
BANK OF AMERICA CORP /DE/ |
45 |
0 |
0.00% |
|
|
