| 1 |
Essex Woodlands Management, Inc. |
1,179,352 |
1,448,000 |
29.55% |
|
|
| 2 |
BVF INC/IL |
865,773 |
1,048,000 |
21.39% |
|
|
| 3 |
NEA Management Company, LLC |
652,380 |
789,000 |
16.10% |
|
|
| 4 |
UBS Group AG |
353,749 |
428,000 |
8.73% |
|
|
| 5 |
VANGUARD GROUP INC |
205,713 |
249,000 |
5.08% |
|
|
| 6 |
RENAISSANCE TECHNOLOGIES LLC |
187,450 |
227,000 |
4.63% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
153,609 |
186,000 |
3.80% |
|
|
| 8 |
COLORADO CAPITAL MANAGEMENT, INC. |
78,375 |
95,000 |
1.94% |
|
|
| 9 |
DAFNA Capital Management LLC |
70,903 |
86,000 |
1.76% |
|
|
| 10 |
DIMENSIONAL FUND ADVISORS LP |
59,224 |
72,000 |
1.47% |
|
|
| 11 |
GOLDMAN SACHS GROUP INC |
42,516 |
51,000 |
1.04% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
25,676 |
31,000 |
0.63% |
|
|
| 13 |
PRICE T ROWE ASSOCIATES INC /MD/ |
24,669 |
30,000 |
0.61% |
|
|
| 14 |
NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC |
23,099 |
28,000 |
0.57% |
|
|
| 15 |
WEDBUSH SECURITIES INC |
21,000 |
25,000 |
0.51% |
|
|
| 16 |
DG Capital Management, LLC |
17,960 |
22,000 |
0.45% |
|
|
| 17 |
CITADEL ADVISORS LLC |
18,361 |
22,000 |
0.45% |
|
|
| 18 |
Bank of New York Mellon Corp |
17,598 |
21,000 |
0.43% |
|
|
| 19 |
Arbor Investment Advisors, LLC |
14,751 |
18,000 |
0.37% |
|
|
| 20 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
13,428 |
16,000 |
0.33% |
|
|
| 21 |
BANK OF AMERICA CORP /DE/ |
1,546 |
2,000 |
0.04% |
|
|
| 22 |
BlackRock Japan Co. Ltd |
2,016 |
2,000 |
0.04% |
|
|
| 23 |
Nationwide Fund Advisors |
1,328 |
2,000 |
0.04% |
|
|
| 24 |
PANAGORA ASSET MANAGEMENT INC |
899 |
1,000 |
0.02% |
|
|
| 25 |
BlackRock Fund Advisors |
683 |
1,000 |
0.02% |
|
|
| 26 |
ROYAL BANK OF CANADA |
174 |
0 |
0.00% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
28 |
0 |
0.00% |
|
|
| 28 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
178 |
0 |
0.00% |
|
|
| 29 |
MORGAN STANLEY |
57 |
0 |
0.00% |
|
|
