| 1 |
Essex Woodlands Management, Inc. |
1,179,352 |
3,779,000 |
27.06% |
|
|
| 2 |
BVF INC/IL |
970,948 |
3,039,000 |
21.76% |
|
|
| 3 |
NEA Management Company, LLC |
652,380 |
2,042,000 |
14.62% |
|
|
| 4 |
UBS Group AG |
358,090 |
1,121,000 |
8.03% |
|
|
| 5 |
VANGUARD GROUP INC |
240,965 |
754,000 |
5.40% |
|
|
| 6 |
DG Capital Management, LLC |
184,995 |
579,000 |
4.15% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
165,291 |
517,000 |
3.70% |
|
|
| 8 |
COLORADO CAPITAL MANAGEMENT, INC. |
78,375 |
245,000 |
1.75% |
|
|
| 9 |
RENAISSANCE TECHNOLOGIES LLC |
76,733 |
240,000 |
1.72% |
|
|
| 10 |
D. E. Shaw & Co., Inc. |
71,934 |
225,000 |
1.61% |
|
|
| 11 |
Avoro Capital Advisors LLC |
71,500 |
224,000 |
1.60% |
|
|
| 12 |
DAFNA Capital Management LLC |
70,903 |
222,000 |
1.59% |
|
|
| 13 |
DIMENSIONAL FUND ADVISORS LP |
67,070 |
210,000 |
1.50% |
|
|
| 14 |
GOLDMAN SACHS GROUP INC |
53,094 |
166,000 |
1.19% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
25,676 |
80,000 |
0.57% |
|
|
| 16 |
Spark Investment Management LLC |
25,700 |
80,000 |
0.57% |
|
|
| 17 |
NORTHWESTERN MUTUAL INVESTMENT MANAGEMENT COMPANY, LLC |
23,099 |
72,000 |
0.52% |
|
|
| 18 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
22,500 |
70,000 |
0.50% |
Call |
|
| 19 |
Bank of New York Mellon Corp |
18,502 |
58,000 |
0.42% |
|
|
| 20 |
Arbor Investment Advisors, LLC |
14,751 |
46,000 |
0.33% |
|
|
| 21 |
Connor, Clark & Lunn Investment Management Ltd. |
14,683 |
46,000 |
0.33% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
13,428 |
42,000 |
0.30% |
|
|
| 23 |
BlackRock Fund Advisors |
10,434 |
33,000 |
0.24% |
|
|
| 24 |
MORGAN STANLEY |
9,771 |
31,000 |
0.22% |
|
|
| 25 |
CUTLER GROUP LLC / CA |
4,339 |
13,000 |
0.09% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
3,486 |
10,000 |
0.07% |
|
|
| 27 |
BlackRock Japan Co. Ltd |
2,337 |
7,000 |
0.05% |
|
|
| 28 |
Nationwide Fund Advisors |
1,328 |
4,000 |
0.03% |
|
|
| 29 |
PANAGORA ASSET MANAGEMENT INC |
899 |
3,000 |
0.02% |
|
|
| 30 |
BlackRock Investment Management, LLC |
923 |
3,000 |
0.02% |
|
|
| 31 |
Tower Research Capital LLC (TRC) |
526 |
2,000 |
0.01% |
|
|
| 32 |
BLACKROCK ADVISORS LLC |
605 |
2,000 |
0.01% |
|
|
| 33 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
178 |
1,000 |
0.01% |
|
|
| 34 |
WELLS FARGO & COMPANY/MN |
1 |
0 |
0.00% |
|
|
| 35 |
Shamrock Asset Management LLC |
57 |
0 |
0.00% |
|
|
| 36 |
CITIGROUP INC |
100 |
0 |
0.00% |
|
|
| 37 |
BANK OF AMERICA CORP /DE/ |
48 |
0 |
0.00% |
|
|
