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Institutional Investment Manager
Opaleye Management Inc.
Opaleye Management Inc. (CIK: 0001595855) incorporated in Massachusetts, located at One Boston Place, Boston, MA. Institutional holdings reported to the SEC.

Institutional Holdings (2016Q1)
Portfolio Summary: 52 holdings with a total value of $160,362,000.
#
Name
Shares
Value ($)
%
Options
Notes
1 AXOGEN INC 2,120,000 11,363,000 7.09%
2 ARIAD PHARMACEUTICALS INC 1,250,000 7,988,000 4.98%
3 ULTRAGENYX PHARMACEUTICAL INC COM 110,000 6,964,000 4.34%
4 FIBROGEN INC COM 325,000 6,919,000 4.31%
5 PROTALIX BIOTHERAPEUTICS INC 8,200,000 6,892,000 4.30%
6 MEDGENICS INC 1,557,700 6,854,000 4.27%
7 ADAMAS PHARMACEUTICALS INC 320,000 6,064,000 3.78%
8 CARA THERAPEUTICS INC 855,000 5,318,000 3.32%
9 SAGE THERAPEUTICS 165,000 5,290,000 3.30%
10 AMAG PHARMACEUTICALS INC COM 220,000 5,148,000 3.21%
11 IMPRIMIS PHARMACEUTICALS INC 1,250,000 4,963,000 3.09%
12 INOTEK PHARMACEUTICALS CORP 645,000 4,773,000 2.98%
13 DEPOMED INC 325,000 4,527,000 2.82%
14 AGIOS PHARMACEUTICALS INC 105,000 4,263,000 2.66%
15 EAGLE PHARMACEUTICALS INC 1,440,000 4,118,000 2.57%
16 BLUEPRINT MEDICINES CORP COM 220,000 3,971,000 2.48%
17 GERON CORP 1,325,000 3,869,000 2.41%
18 Foamix Pharmaceuticals Ltd. 590,000 3,847,000 2.40%
19 CODEXIS INC 1,178,500 3,665,000 2.29%
20 TG THERAPEUTICS INC COM 415,000 3,536,000 2.21%
21 CHIMERIX INC 675,000 3,449,000 2.15%
22 OPHTHOTECH CORP COM 80,000 3,382,000 2.11%
23 IMMUNOMEDICS INC 1,325,000 3,313,000 2.07%
24 XENON PHARMACEUTICALS INC 400,000 2,796,000 1.74%
25 AMARIN CORP PLC 1,760,000 2,693,000 1.68%
26 Intec Pharma Ltd 638,000 2,629,000 1.64%
27 Nabriva Therapeutics AG 273,800 2,453,000 1.53%
28 EAGLE PHARMACEUTICALS INC COM 60,000 2,430,000 1.52%
29 AFFIMED N V 610,000 2,281,000 1.42%
30 ZOGENIX INC 240,000 2,218,000 1.38%
31 RETROPHIN INC COM 150,000 2,049,000 1.28%
32 SUPERNUS PHARMACEUTICALS INC COM 125,000 1,906,000 1.19%
33 TRILLIUM THERAPEUTICS INC 195,000 1,804,000 1.12%
34 EDGE THERAPEUTICS INC 185,000 1,693,000 1.06%
35 CYNAPSUS THERAPEUTICS INC 121,000 1,440,000 0.90%
36 ADAPTIMMUNE THERAPEUTICS PLC 175,300 1,425,000 0.89%
37 CORIUM INTERNATIONAL INC 360,000 1,390,000 0.87%
38 AURIS MED HLDG AG 340,000 1,238,000 0.77%
39 OHR PHARMACEUTICAL INC 366,000 1,175,000 0.73%
40 PROTEON THERAPEUTICS INC 150,000 1,161,000 0.72%
41 XOMA CORP DEL 1,350,000 1,044,000 0.65%
42 TENAX THERAPEUTICS INC COM 499,600 1,024,000 0.64%
43 ACHAOGEN INC COM 255,000 704,000 0.44%
44 NEKTAR THERAPEUTICS COM 50,000 688,000 0.43%
45 MEDIVATION INC 14,500 667,000 0.42%
46 Evoke Pharma Inc 130,000 662,000 0.41%
47 PROTHENA CORP PLC 14,000 576,000 0.36%
48 NEURODERM LTD 38,500 544,000 0.34%
49 Nivalis Therapeutics Inc 100,000 417,000 0.26%
50 ACLARIS THERAPEUTICS INC COM 18,000 341,000 0.21%
Page 1 of 2

Portfolio data is normalized using SEC Form 13F filings, including the Restatement filing (0001546927-16-000499, filed 2016.05.27).

From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.