| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 1,252,114 | 17,930,000 | 20.45% | ||
| 2 | DSC Advisors, L.P. | 938,598 | 13,105,000 | 14.95% | ||
| 3 | Sio Capital Management, LLC | 781,514 | 11,191,000 | 12.77% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 458,332 | 6,563,000 | 7.49% | ||
| 5 | EMERALD MUTUAL FUND ADVISERS TRUST | 412,058 | 5,901,000 | 6.73% | ||
| 6 | EMERALD ADVISERS, LLC | 378,874 | 5,425,000 | 6.19% | ||
| 7 | BlackRock Fund Advisors | 336,227 | 4,815,000 | 5.49% | ||
| 8 | PUTNAM INVESTMENTS LLC | 215,000 | 3,079,000 | 3.51% | ||
| 9 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 212,075 | 3,037,000 | 3.46% | ||
| 10 | WALL STREET ASSOCIATES | 149,343 | 2,139,000 | 2.44% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 142,603 | 2,042,000 | 2.33% | ||
| 12 | VANGUARD GROUP INC | 129,388 | 1,853,000 | 2.11% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 114,111 | 1,634,000 | 1.86% | ||
| 14 | MARSHALL WACE, LLP | 96,162 | 1,377,000 | 1.57% | ||
| 15 | DAFNA Capital Management LLC | 63,400 | 908,000 | 1.04% | ||
| 16 | NORTHERN TRUST CORP | 62,991 | 902,000 | 1.03% | ||
| 17 | STATE STREET CORP | 54,039 | 774,000 | 0.88% | ||
| 18 | Cormorant Asset Management, LP | 50,000 | 716,000 | 0.82% | ||
| 19 | RENAISSANCE TECHNOLOGIES LLC | 42,500 | 609,000 | 0.69% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 36,701 | 525,000 | 0.60% | ||
| 21 | Numeric Investors LLC | 29,191 | 418,000 | 0.48% | ||
| 22 | CITADEL ADVISORS LLC | 26,087 | 374,000 | 0.43% | ||
| 23 | BlackRock Investment Management, LLC | 19,915 | 285,000 | 0.33% | ||
| 24 | Bank of New York Mellon Corp | 16,545 | 237,000 | 0.27% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 16,023 | 229,000 | 0.26% | ||
| 26 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 15,800 | 226,000 | 0.26% | ||
| 27 | NEXTHERA CAPITAL LP | 15,000 | 215,000 | 0.25% | ||
| 28 | DEUTSCHE BANK AG\ | 14,033 | 199,000 | 0.23% | ||
| 29 | ProShare Advisors LLC | 13,623 | 195,000 | 0.22% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,200 | 146,000 | 0.17% | ||
| 31 | BAMCO INC /NY/ | 10,000 | 143,000 | 0.16% | ||
| 32 | TEACHERS ADVISORS, LLC | 5,628 | 81,000 | 0.09% | ||
| 33 | CITIGROUP INC | 5,346 | 77,000 | 0.09% | ||
| 34 | MORGAN STANLEY | 4,806 | 69,000 | 0.08% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 3,700 | 53,000 | 0.06% | ||
| 36 | UBS Group AG | 3,561 | 51,000 | 0.06% | ||
| 37 | Nationwide Fund Advisors | 3,245 | 46,000 | 0.05% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 2,692 | 39,000 | 0.04% | ||
| 39 | STRS OHIO | 1,800 | 25,000 | 0.03% | ||
| 40 | BLACKROCK ADVISORS LLC | 1,165 | 17,000 | 0.02% | ||
| 41 | BNP PARIBAS FINANCIAL MARKETS | 497 | 7,117 | 0.01% | ||
| 42 | Catalyst Capital Advisors LLC | 205 | 3,000 | 0.00% | ||
| 43 | BARCLAYS PLC | 265 | 3,000 | 0.00% | ||
| 44 | WELLS FARGO & COMPANY/MN | 15 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
