| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,683,731 | 147,717,000 | 43.79% | ||
| 2 | Redmile Group, LLC | 1,562,587 | 51,010,000 | 15.12% | ||
| 3 | PFM Health Sciences, LP | 381,270 | 15,289,000 | 4.53% | ||
| 4 | Capital World Investors | 361,649 | 14,502,000 | 4.30% | ||
| 5 | MORGAN STANLEY | 284,900 | 11,424,000 | 3.39% | ||
| 6 | LORD, ABBETT & CO. LLC | 271,303 | 10,879,000 | 3.22% | ||
| 7 | Rock Springs Capital Management LP | 195,000 | 7,820,000 | 2.32% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 178,215 | 7,146,000 | 2.12% | ||
| 9 | FRANKLIN RESOURCES INC | 172,564 | 6,920,000 | 2.05% | ||
| 10 | Clearbridge Investments, LLC | 120,000 | 4,812,000 | 1.43% | ||
| 11 | RS INVESTMENT MANAGEMENT CO LLC | 115,701 | 4,640,000 | 1.38% | ||
| 12 | ARROWGRASS CAPITAL PARTNERS (US) LP | 115,588 | 4,635,000 | 1.37% | ||
| 13 | FEDERATED HERMES, INC. | 110,000 | 4,411,000 | 1.31% | ||
| 14 | OppenheimerFunds, Inc. | 106,300 | 4,263,000 | 1.26% | ||
| 15 | Novo Holdings A/S | 104,944 | 4,208,000 | 1.25% | ||
| 16 | Capital Research Global Investors | 103,589 | 4,154,000 | 1.23% | ||
| 17 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 100,000 | 4,010,000 | 1.19% | ||
| 18 | PRIMECAP MANAGEMENT CO/CA/ | 100,000 | 4,010,000 | 1.19% | ||
| 19 | Invesco Ltd. | 100,000 | 4,010,000 | 1.19% | ||
| 20 | DEERFIELD MANAGEMENT COMPANY, L.P. | 100,000 | 4,010,000 | 1.19% | ||
| 21 | JENNISON ASSOCIATES LLC | 65,000 | 2,607,000 | 0.77% | ||
| 22 | WADDELL & REED FINANCIAL INC | 50,000 | 2,005,000 | 0.59% | ||
| 23 | MILLENNIUM MANAGEMENT LLC | 28,425 | 1,140,000 | 0.34% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 26,171 | 1,049,000 | 0.31% | ||
| 25 | PURA VIDA INVESTMENTS, LLC | 25,800 | 1,035,000 | 0.31% | ||
| 26 | LAZARD ASSET MANAGEMENT LLC | 23,500 | 942,000 | 0.28% | ||
| 27 | Laurion Capital Management LP | 22,501 | 902,000 | 0.27% | ||
| 28 | CITADEL ADVISORS LLC | 22,242 | 892,000 | 0.26% | ||
| 29 | JPMORGAN CHASE & CO | 19,975 | 801,000 | 0.24% | ||
| 30 | Lisanti Capital Growth, LLC | 15,250 | 612,000 | 0.18% | ||
| 31 | EMERALD ADVISERS, LLC | 15,040 | 603,000 | 0.18% | ||
| 32 | NORGES BANK | 15,000 | 602,000 | 0.18% | ||
| 33 | VANGUARD GROUP INC | 14,993 | 601,000 | 0.18% | ||
| 34 | EMERALD MUTUAL FUND ADVISERS TRUST | 14,960 | 600,000 | 0.18% | ||
| 35 | Visium Asset Management, LP | 13,536 | 543,000 | 0.16% | ||
| 36 | BELLEVUE ASSET MANAGEMENT AG | 10,000 | 401,000 | 0.12% | ||
| 37 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 9,980 | 400,000 | 0.12% | ||
| 38 | Partner Investment Management, L.P. | 8,986 | 360,000 | 0.11% | ||
| 39 | Geduld E E | 7,500 | 301,000 | 0.09% | ||
| 40 | Nationwide Fund Advisors | 7,470 | 300,000 | 0.09% | ||
| 41 | TUDOR INVESTMENT CORP ET AL | 6,700 | 269,000 | 0.08% | ||
| 42 | Artisan Partners Limited Partnership | 5,000 | 200,000 | 0.06% | ||
| 43 | BlackRock Group LTD | 4,799 | 192,000 | 0.06% | ||
| 44 | ROYCE & ASSOCIATES LP | 1,000 | 40,000 | 0.01% | ||
| 45 | GILDER GAGNON HOWE & CO LLC | 666 | 27,000 | 0.01% | ||
| 46 | CREDIT AGRICOLE S A | 500 | 20,000 | 0.01% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 406 | 16,000 | 0.00% | ||
| 48 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 350 | 14,000 | 0.00% | ||
| 49 | UBS Group AG | 200 | 8,000 | 0.00% | ||
| 50 | BlackRock Institutional Trust Company, N.A. | 201 | 8,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
