| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,826,391 | 205,898,000 | 41.36% | ||
| 2 | Redmile Group, LLC | 1,537,570 | 76,213,000 | 15.31% | ||
| 3 | LORD, ABBETT & CO. LLC | 692,001 | 37,236,000 | 7.48% | ||
| 4 | Invesco Ltd. | 491,356 | 26,440,000 | 5.31% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 642,127 | 25,749,000 | 5.17% | ||
| 6 | Capital World Investors | 388,487 | 20,904,000 | 4.20% | ||
| 7 | MORGAN STANLEY | 276,937 | 14,902,000 | 2.99% | ||
| 8 | Novo Holdings A/S | 236,144 | 12,707,000 | 2.55% | ||
| 9 | Rock Springs Capital Management LP | 205,000 | 11,031,000 | 2.22% | ||
| 10 | FRANKLIN RESOURCES INC | 181,704 | 9,777,000 | 1.96% | ||
| 11 | Clearbridge Investments, LLC | 119,995 | 6,457,000 | 1.30% | ||
| 12 | BlackRock Fund Advisors | 113,121 | 6,087,000 | 1.22% | ||
| 13 | Capital Research Global Investors | 103,589 | 5,574,000 | 1.12% | ||
| 14 | PRIMECAP MANAGEMENT CO/CA/ | 101,300 | 5,451,000 | 1.09% | ||
| 15 | GILDER GAGNON HOWE & CO LLC | 79,816 | 4,295,000 | 0.86% | ||
| 16 | VANGUARD GROUP INC | 64,210 | 3,456,000 | 0.69% | ||
| 17 | LAZARD ASSET MANAGEMENT LLC | 62,975 | 3,388,000 | 0.68% | ||
| 18 | STATE STREET CORP | 51,997 | 2,797,000 | 0.56% | ||
| 19 | PFM Health Sciences, LP | 46,531 | 2,504,000 | 0.50% | ||
| 20 | NORTHERN TRUST CORP | 46,182 | 2,485,000 | 0.50% | ||
| 21 | DRIEHAUS CAPITAL MANAGEMENT LLC | 31,259 | 1,682,000 | 0.34% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 25,806 | 1,389,000 | 0.28% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 21,074 | 1,133,000 | 0.23% | ||
| 24 | Lisanti Capital Growth, LLC | 20,234 | 1,089,000 | 0.22% | ||
| 25 | JPMORGAN CHASE & CO | 19,925 | 1,072,000 | 0.22% | ||
| 26 | BlackRock Investment Management, LLC | 15,190 | 817,000 | 0.16% | ||
| 27 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 15,074 | 811,000 | 0.16% | ||
| 28 | NORGES BANK | 15,000 | 807,000 | 0.16% | ||
| 29 | Bank of New York Mellon Corp | 13,514 | 727,000 | 0.15% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,086 | 705,000 | 0.14% | ||
| 31 | D. E. Shaw & Co., Inc. | 12,166 | 655,000 | 0.13% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 10,429 | 561,000 | 0.11% | ||
| 33 | FEDERATED HERMES, INC. | 10,000 | 538,000 | 0.11% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,500 | 457,000 | 0.09% | ||
| 35 | TEACHERS ADVISORS, LLC | 6,580 | 354,000 | 0.07% | ||
| 36 | METROPOLITAN LIFE INSURANCE CO/NY | 6,040 | 325,000 | 0.07% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 5,225 | 281,000 | 0.06% | ||
| 38 | GSA CAPITAL PARTNERS LLP | 4,200 | 226,000 | 0.05% | ||
| 39 | Nationwide Fund Advisors | 3,608 | 194,000 | 0.04% | ||
| 40 | CITIGROUP INC | 1,629 | 88,000 | 0.02% | ||
| 41 | Tower Research Capital LLC (TRC) | 1,560 | 84,000 | 0.02% | ||
| 42 | STRS OHIO | 1,500 | 80,000 | 0.02% | ||
| 43 | BLACKROCK ADVISORS LLC | 1,428 | 77,000 | 0.02% | ||
| 44 | WELLS FARGO & COMPANY/MN | 1,330 | 72,000 | 0.01% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 1,181 | 64,000 | 0.01% | ||
| 46 | DEUTSCHE BANK AG\ | 1,156 | 61,000 | 0.01% | ||
| 47 | ROYCE & ASSOCIATES LP | 1,000 | 54,000 | 0.01% | ||
| 48 | BNP PARIBAS FINANCIAL MARKETS | 468 | 25,183 | 0.01% | ||
| 49 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 350 | 19,000 | 0.00% | ||
| 50 | UBS Group AG | 250 | 14,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
