| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,746,579 | 302,831,000 | 24.51% | ||
| 2 | VANGUARD GROUP INC | 1,934,521 | 123,423,000 | 9.99% | ||
| 3 | ALLIANCEBERNSTEIN L.P. | 1,300,199 | 82,953,000 | 6.72% | ||
| 4 | Redmile Group, LLC | 1,040,208 | 66,365,000 | 5.37% | ||
| 5 | BlackRock Fund Advisors | 838,118 | 53,472,000 | 4.33% | ||
| 6 | BlackRock Institutional Trust Company, N.A. | 658,811 | 42,032,000 | 3.40% | ||
| 7 | Invesco Ltd. | 590,894 | 37,700,000 | 3.05% | ||
| 8 | FEDERATED HERMES, INC. | 519,940 | 33,172,000 | 2.69% | ||
| 9 | CARRET ASSET MANAGEMENT, LLC | 505,961 | 32,280,000 | 2.61% | ||
| 10 | STATE STREET CORP | 472,199 | 30,130,000 | 2.44% | ||
| 11 | LORD, ABBETT & CO. LLC | 349,655 | 22,308,000 | 1.81% | ||
| 12 | Champlain Investment Partners, LLC | 309,230 | 19,729,000 | 1.60% | ||
| 13 | NORTHERN TRUST CORP | 298,465 | 19,042,000 | 1.54% | ||
| 14 | OAK RIDGE INVESTMENTS LLC | 298,193 | 19,025,000 | 1.54% | ||
| 15 | Rock Springs Capital Management LP | 295,500 | 18,853,000 | 1.53% | ||
| 16 | WADDELL & REED FINANCIAL INC | 290,970 | 18,564,000 | 1.50% | ||
| 17 | MORGAN STANLEY | 282,062 | 17,995,000 | 1.46% | ||
| 18 | PFM Health Sciences, LP | 231,892 | 14,795,000 | 1.20% | ||
| 19 | Neuberger Berman Group LLC | 226,000 | 14,419,000 | 1.17% | ||
| 20 | FRANKLIN RESOURCES INC | 202,374 | 12,911,000 | 1.05% | ||
| 21 | Capital World Investors | 194,244 | 12,393,000 | 1.00% | ||
| 22 | Clearbridge Investments, LLC | 187,396 | 11,956,000 | 0.97% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 186,144 | 11,875,000 | 0.96% | ||
| 24 | OppenheimerFunds, Inc. | 180,870 | 11,540,000 | 0.93% | ||
| 25 | WELLINGTON MANAGEMENT GROUP LLP | 173,274 | 11,055,000 | 0.89% | ||
| 26 | Artisan Partners Limited Partnership | 155,452 | 9,918,000 | 0.80% | ||
| 27 | NEXT CENTURY GROWTH INVESTORS LLC | 139,436 | 8,896,000 | 0.72% | ||
| 28 | Mariner, LLC | 137,750 | 8,788,000 | 0.71% | ||
| 29 | Allianz Asset Management GmbH | 137,486 | 8,772,000 | 0.71% | ||
| 30 | Bank of New York Mellon Corp | 129,395 | 8,256,000 | 0.67% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 104,636 | 6,676,000 | 0.54% | ||
| 32 | HIGHLAND CAPITAL MANAGEMENT LP | 100,375 | 6,404,000 | 0.52% | ||
| 33 | BlackRock Investment Management, LLC | 95,411 | 6,087,000 | 0.49% | ||
| 34 | PURA VIDA INVESTMENTS, LLC | 95,000 | 6,061,000 | 0.49% | ||
| 35 | GOLDMAN SACHS GROUP INC | 87,568 | 5,587,000 | 0.45% | ||
| 36 | Nationwide Fund Advisors | 79,043 | 5,043,000 | 0.41% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 72,600 | 4,632,000 | 0.37% | ||
| 38 | Pier Capital, LLC | 72,156 | 4,604,000 | 0.37% | ||
| 39 | AMUNDI ASSET MANAGEMENT US, INC. | 67,629 | 4,315,000 | 0.35% | ||
| 40 | PRIMECAP MANAGEMENT CO/CA/ | 66,000 | 4,211,000 | 0.34% | ||
| 41 | BALASA DINVERNO & FOLTZ LLC | 61,640 | 3,933,000 | 0.32% | ||
| 42 | Timpani Capital Management LLC | 60,252 | 3,844,000 | 0.31% | ||
| 43 | RUSSELL INVESTMENTS GROUP, LTD. | 54,347 | 3,484,000 | 0.28% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 52,483 | 3,348,000 | 0.27% | ||
| 45 | NEW YORK STATE COMMON RETIREMENT FUND | 52,404 | 3,343,000 | 0.27% | ||
| 46 | LOOMIS SAYLES & CO L P | 51,554 | 3,289,000 | 0.27% | ||
| 47 | Endurant Capital Management LP | 49,500 | 3,158,000 | 0.26% | ||
| 48 | Swiss National Bank | 43,400 | 2,769,000 | 0.22% | ||
| 49 | Nicholas Investment Partners, LP | 42,191 | 2,690,000 | 0.22% | ||
| 50 | TEACHERS ADVISORS, LLC | 42,130 | 2,688,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
