| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,494,768 | 267,439,000 | 27.61% | ||
| 2 | VANGUARD GROUP INC | 1,529,260 | 90,990,000 | 9.39% | ||
| 3 | Redmile Group, LLC | 863,581 | 51,383,000 | 5.30% | ||
| 4 | LORD, ABBETT & CO. LLC | 843,321 | 50,178,000 | 5.18% | ||
| 5 | Consonance Capital Management LP | 684,079 | 40,703,000 | 4.20% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 674,307 | 40,121,000 | 4.14% | ||
| 7 | BlackRock Fund Advisors | 603,188 | 35,890,000 | 3.70% | ||
| 8 | Invesco Ltd. | 579,489 | 34,480,000 | 3.56% | ||
| 9 | CARRET ASSET MANAGEMENT, LLC | 544,720 | 32,411,000 | 3.35% | ||
| 10 | STATE STREET CORP | 389,257 | 23,166,000 | 2.39% | ||
| 11 | FEDERATED HERMES, INC. | 333,200 | 19,825,000 | 2.05% | ||
| 12 | Phocas Financial Corp. | 307,774 | 18,313,000 | 1.89% | SH | |
| 13 | MORGAN STANLEY | 286,728 | 17,061,000 | 1.76% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 244,909 | 14,572,000 | 1.50% | ||
| 15 | Rock Springs Capital Management LP | 242,500 | 14,429,000 | 1.49% | ||
| 16 | FRANKLIN RESOURCES INC | 207,295 | 12,334,000 | 1.27% | ||
| 17 | Capital World Investors | 194,244 | 11,558,000 | 1.19% | ||
| 18 | UBS Group AG | 185,319 | 11,026,000 | 1.14% | ||
| 19 | NORGES BANK | 182,141 | 10,837,000 | 1.12% | ||
| 20 | WADDELL & REED FINANCIAL INC | 165,000 | 9,817,000 | 1.01% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 158,600 | 9,437,000 | 0.97% | ||
| 22 | Mariner, LLC | 137,750 | 8,196,000 | 0.85% | ||
| 23 | Bank of New York Mellon Corp | 121,834 | 7,249,000 | 0.75% | ||
| 24 | NEXT CENTURY GROWTH INVESTORS LLC | 120,293 | 7,157,000 | 0.74% | ||
| 25 | Clearbridge Investments, LLC | 119,248 | 7,095,000 | 0.73% | ||
| 26 | GOLDMAN SACHS GROUP INC | 101,943 | 6,066,000 | 0.63% | ||
| 27 | DEUTSCHE BANK AG\ | 99,587 | 5,924,000 | 0.61% | ||
| 28 | NORTHERN TRUST CORP | 95,964 | 5,711,000 | 0.59% | ||
| 29 | BlackRock Investment Management, LLC | 94,690 | 5,634,000 | 0.58% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 87,822 | 5,225,000 | 0.54% | ||
| 31 | PRIMECAP MANAGEMENT CO/CA/ | 84,600 | 5,034,000 | 0.52% | ||
| 32 | BALASA DINVERNO & FOLTZ LLC | 79,944 | 4,757,000 | 0.49% | ||
| 33 | BANK OF MONTREAL /CAN/ | 62,000 | 3,689,000 | 0.38% | ||
| 34 | D. E. Shaw & Co., Inc. | 55,555 | 3,306,000 | 0.34% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 54,947 | 3,269,000 | 0.34% | ||
| 36 | Informed Momentum Co LLC | 54,747 | 3,257,000 | 0.34% | ||
| 37 | DRIEHAUS CAPITAL MANAGEMENT LLC | 53,545 | 3,186,000 | 0.33% | ||
| 38 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,383 | 3,176,000 | 0.33% | ||
| 39 | LAZARD ASSET MANAGEMENT LLC | 50,975 | 3,033,000 | 0.31% | ||
| 40 | Nicholas Investment Partners, LP | 47,434 | 2,822,000 | 0.29% | ||
| 41 | Cortina Asset Management, LLC | 47,111 | 2,803,000 | 0.29% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,758 | 2,664,000 | 0.27% | ||
| 43 | Swiss National Bank | 41,200 | 2,451,000 | 0.25% | ||
| 44 | TEACHERS ADVISORS, LLC | 40,645 | 2,418,000 | 0.25% | ||
| 45 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 40,066 | 2,384,000 | 0.25% | ||
| 46 | EMERALD ACQUISITION LTD. | 39,919 | 2,375,000 | 0.25% | ||
| 47 | Timpani Capital Management LLC | 39,280 | 2,337,000 | 0.24% | ||
| 48 | PFM Health Sciences, LP | 38,186 | 2,272,000 | 0.23% | ||
| 49 | Cupps Capital Management, LLC | 37,984 | 2,260,000 | 0.23% | ||
| 50 | GILDER GAGNON HOWE & CO LLC | 30,765 | 1,831,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
