| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,216,046 | 193,938,000 | 38.48% | ||
| 2 | Redmile Group, LLC | 1,267,967 | 58,326,000 | 11.57% | ||
| 3 | LORD, ABBETT & CO. LLC | 639,137 | 29,401,000 | 5.83% | ||
| 4 | Invesco Ltd. | 578,703 | 26,620,000 | 5.28% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 522,790 | 24,048,000 | 4.77% | ||
| 6 | Phocas Financial Corp. | 456,381 | 20,994,000 | 4.17% | SH | |
| 7 | FEDERATED HERMES, INC. | 333,200 | 15,327,000 | 3.04% | ||
| 8 | MORGAN STANLEY | 274,210 | 12,614,000 | 2.50% | ||
| 9 | Novo Holdings A/S | 263,191 | 12,107,000 | 2.40% | ||
| 10 | Rock Springs Capital Management LP | 228,500 | 10,511,000 | 2.09% | ||
| 11 | UBS Group AG | 215,445 | 9,910,000 | 1.97% | ||
| 12 | Capital World Investors | 194,244 | 8,935,000 | 1.77% | ||
| 13 | FRANKLIN RESOURCES INC | 146,304 | 6,730,000 | 1.34% | ||
| 14 | Clearbridge Investments, LLC | 118,296 | 5,442,000 | 1.08% | ||
| 15 | BlackRock Fund Advisors | 107,747 | 4,956,000 | 0.98% | ||
| 16 | NORGES BANK | 90,782 | 4,176,000 | 0.83% | ||
| 17 | PRIMECAP MANAGEMENT CO/CA/ | 86,800 | 3,993,000 | 0.79% | ||
| 18 | JANUS HENDERSON INVESTORS US LLC | 85,615 | 3,938,000 | 0.78% | ||
| 19 | MARSHALL WACE, LLP | 82,891 | 3,813,000 | 0.76% | ||
| 20 | GILDER GAGNON HOWE & CO LLC | 80,617 | 3,708,000 | 0.74% | ||
| 21 | PFM Health Sciences, LP | 63,045 | 2,900,000 | 0.58% | ||
| 22 | LAZARD ASSET MANAGEMENT LLC | 62,975 | 2,896,000 | 0.57% | ||
| 23 | STATE STREET CORP | 60,983 | 2,806,000 | 0.56% | ||
| 24 | VANGUARD GROUP INC | 58,990 | 2,714,000 | 0.54% | ||
| 25 | Cupps Capital Management, LLC | 58,590 | 2,695,000 | 0.53% | ||
| 26 | Informed Momentum Co LLC | 52,552 | 2,417,000 | 0.48% | ||
| 27 | Bank of New York Mellon Corp | 50,347 | 2,317,000 | 0.46% | ||
| 28 | NORTHERN TRUST CORP | 46,467 | 2,138,000 | 0.42% | ||
| 29 | Consonance Capital Management LP | 40,000 | 1,840,000 | 0.37% | ||
| 30 | Nicholas Investment Partners, LP | 37,423 | 1,721,000 | 0.34% | ||
| 31 | BlackRock Institutional Trust Company, N.A. | 37,156 | 1,709,000 | 0.34% | ||
| 32 | AMERIPRISE FINANCIAL INC | 31,232 | 1,437,000 | 0.29% | ||
| 33 | DRIEHAUS CAPITAL MANAGEMENT LLC | 30,170 | 1,388,000 | 0.28% | ||
| 34 | GEODE CAPITAL MANAGEMENT, LLC | 29,670 | 1,364,000 | 0.27% | ||
| 35 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 28,505 | 1,311,000 | 0.26% | ||
| 36 | Endurant Capital Management LP | 24,700 | 1,136,000 | 0.23% | ||
| 37 | JPMORGAN CHASE & CO | 21,052 | 968,000 | 0.19% | ||
| 38 | Laurion Capital Management LP | 20,100 | 925,000 | 0.18% | ||
| 39 | PNC FINANCIAL SERVICES GROUP, INC. | 18,254 | 840,000 | 0.17% | ||
| 40 | BlackRock Investment Management, LLC | 15,664 | 721,000 | 0.14% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,290 | 612,000 | 0.12% | ||
| 42 | TWO SIGMA INVESTMENTS, LP | 12,993 | 598,000 | 0.12% | ||
| 43 | RUSSELL FRANK CO/ | 12,521 | 576,000 | 0.11% | ||
| 44 | GSA CAPITAL PARTNERS LLP | 11,800 | 543,000 | 0.11% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 10,429 | 480,000 | 0.10% | ||
| 46 | CITADEL ADVISORS LLC | 10,093 | 464,000 | 0.09% | ||
| 47 | MENTA CAPITAL LLC | 10,000 | 460,000 | 0.09% | ||
| 48 | A.R.T. Advisors, LLC | 9,700 | 446,000 | 0.09% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 9,699 | 446,000 | 0.09% | ||
| 50 | Asset Management One Co., Ltd. | 9,082 | 410,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
