| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VIVO CAPITAL, LLC | 4,191,397 | 79,427,000 | 28.70% | ||
| 2 | FMR LLC | 3,804,279 | 72,091,000 | 26.05% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 2,627,719 | 49,795,000 | 17.99% | ||
| 4 | FRANKLIN RESOURCES INC | 1,639,454 | 31,067,000 | 11.23% | ||
| 5 | Rock Springs Capital Management LP | 895,500 | 16,970,000 | 6.13% | ||
| 6 | Cormorant Asset Management, LP | 647,944 | 12,279,000 | 4.44% | ||
| 7 | VANGUARD GROUP INC | 169,296 | 3,208,000 | 1.16% | ||
| 8 | BlackRock Fund Advisors | 146,957 | 2,785,000 | 1.01% | ||
| 9 | TURNER INVESTMENTS LLC | 87,004 | 1,649,000 | 0.60% | ||
| 10 | STATE STREET CORP | 72,831 | 1,379,000 | 0.50% | ||
| 11 | NORTHERN TRUST CORP | 57,351 | 1,086,000 | 0.39% | ||
| 12 | NORGES BANK | 50,000 | 948,000 | 0.34% | ||
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 43,246 | 819,000 | 0.30% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 28,286 | 536,000 | 0.19% | ||
| 15 | BlackRock Investment Management, LLC | 20,419 | 387,000 | 0.14% | ||
| 16 | Opaleye Management Inc. | 18,000 | 341,000 | 0.12% | ||
| 17 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 16,863 | 320,000 | 0.12% | ||
| 18 | Bank of New York Mellon Corp | 15,521 | 294,000 | 0.11% | ||
| 19 | TIAA CREF INVESTMENT MANAGEMENT LLC | 12,953 | 245,000 | 0.09% | ||
| 20 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 12,213 | 231,000 | 0.08% | ||
| 21 | Geduld E E | 10,771 | 204,000 | 0.07% | ||
| 22 | CITIGROUP INC | 8,490 | 161,000 | 0.06% | ||
| 23 | TEACHERS ADVISORS, LLC | 7,440 | 141,000 | 0.05% | ||
| 24 | Nationwide Fund Advisors | 3,909 | 74,000 | 0.03% | ||
| 25 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,110 | 64,000 | 0.02% | ||
| 26 | AMERICAN INTERNATIONAL GROUP, INC. | 3,321 | 63,000 | 0.02% | ||
| 27 | NEW YORK STATE COMMON RETIREMENT FUND | 2,449 | 46,000 | 0.02% | ||
| 28 | BLACKROCK ADVISORS LLC | 1,937 | 37,000 | 0.01% | ||
| 29 | STRS OHIO | 1,900 | 36,000 | 0.01% | ||
| 30 | WELLS FARGO & COMPANY/MN | 1,858 | 30,000 | 0.01% | ||
| 31 | DEUTSCHE BANK AG\ | 864 | 16,000 | 0.01% | ||
| 32 | UBS Group AG | 633 | 12,000 | 0.00% | ||
| 33 | BlackRock Finance, Inc. | 349 | 7,000 | 0.00% | ||
| 34 | Tower Research Capital LLC (TRC) | 186 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
