| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,411,681 | 69,811,000 | 30.76% | ||
| 2 | CANAAN PARTNERS IX LLC | 4,884,755 | 63,013,000 | 27.76% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 943,433 | 12,170,000 | 5.36% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 749,055 | 9,663,000 | 4.26% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 742,021 | 9,572,000 | 4.22% | ||
| 6 | Redmile Group, LLC | 729,699 | 9,413,000 | 4.15% | ||
| 7 | BVF INC/IL | 606,138 | 7,819,000 | 3.45% | ||
| 8 | VHCP MANAGEMENT II, LLC | 577,831 | 7,429,000 | 3.27% | ||
| 9 | Cormorant Asset Management, LP | 371,023 | 4,786,000 | 2.11% | ||
| 10 | Tekla Capital Management LLC | 328,059 | 4,232,000 | 1.86% | ||
| 11 | PUTNAM INVESTMENTS LLC | 325,000 | 4,192,000 | 1.85% | ||
| 12 | CASDIN CAPITAL, LLC | 321,023 | 4,141,000 | 1.82% | ||
| 13 | FRANKLIN RESOURCES INC | 300,000 | 3,870,000 | 1.71% | ||
| 14 | VANGUARD GROUP INC | 230,056 | 2,968,000 | 1.31% | ||
| 15 | BlackRock Fund Advisors | 196,282 | 2,532,000 | 1.12% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 1,935,000 | 0.85% | ||
| 17 | STATE STREET CORP | 91,777 | 1,182,000 | 0.52% | ||
| 18 | NORTHERN TRUST CORP | 73,717 | 951,000 | 0.42% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 68,254 | 880,000 | 0.39% | ||
| 20 | VHCP Management, LLC | 64,200 | 828,000 | 0.36% | ||
| 21 | GLOBEFLEX CAPITAL L P | 59,000 | 761,000 | 0.34% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 57,918 | 747,000 | 0.33% | ||
| 23 | Informed Momentum Co LLC | 45,784 | 591,000 | 0.26% | ||
| 24 | Candriam S.C.A. | 42,000 | 539,000 | 0.24% | ||
| 25 | RUSSELL FRANK CO/ | 32,451 | 419,000 | 0.18% | ||
| 26 | Spark Investment Management LLC | 30,900 | 398,000 | 0.18% | ||
| 27 | BlackRock Investment Management, LLC | 27,431 | 354,000 | 0.16% | ||
| 28 | Bank of New York Mellon Corp | 23,264 | 300,000 | 0.13% | ||
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,928 | 296,000 | 0.13% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 17,210 | 222,000 | 0.10% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 16,223 | 209,000 | 0.09% | ||
| 32 | TEACHERS ADVISORS, LLC | 7,663 | 99,000 | 0.04% | ||
| 33 | NEW YORK STATE COMMON RETIREMENT FUND | 7,300 | 94,000 | 0.04% | ||
| 34 | CITIGROUP INC | 6,281 | 81,000 | 0.04% | ||
| 35 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,800 | 74,000 | 0.03% | ||
| 36 | Vident Investment Advisory, LLC | 952,408 | 74,000 | 0.03% | ||
| 37 | Nationwide Fund Advisors | 5,237 | 68,000 | 0.03% | ||
| 38 | AMERICAN INTERNATIONAL GROUP, INC. | 4,426 | 57,000 | 0.03% | ||
| 39 | BLACKROCK ADVISORS LLC | 2,550 | 33,000 | 0.01% | ||
| 40 | STRS OHIO | 2,500 | 32,000 | 0.01% | ||
| 41 | WELLS FARGO & COMPANY/MN | 2,363 | 31,000 | 0.01% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 1,754 | 23,000 | 0.01% | ||
| 43 | DEUTSCHE BANK AG\ | 1,172 | 15,000 | 0.01% | ||
| 44 | MORGAN STANLEY | 1,000 | 13,000 | 0.01% | ||
| 45 | ACROSPIRE INVESTMENT MANAGEMENT LLC | 1,000 | 13,000 | 0.01% | ||
| 46 | FIFTH THIRD BANCORP | 740 | 10,000 | 0.00% | ||
| 47 | Tower Research Capital LLC (TRC) | 690 | 9,000 | 0.00% | ||
| 48 | UBS Group AG | 402 | 5,000 | 0.00% | ||
| 49 | BlackRock Finance, Inc. | 106 | 1,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
