| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,460,352 | 60,009,000 | 32.39% | ||
| 2 | PUTNAM INVESTMENTS LLC | 1,364,492 | 14,996,000 | 8.09% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 943,433 | 10,368,000 | 5.60% | ||
| 4 | PERCEPTIVE ADVISORS LLC | 923,763 | 10,152,000 | 5.48% | ||
| 5 | VANGUARD GROUP INC | 795,999 | 8,748,000 | 4.72% | ||
| 6 | Tekla Capital Management LLC | 756,090 | 8,309,000 | 4.48% | ||
| 7 | Redmile Group, LLC | 696,992 | 7,660,000 | 4.13% | ||
| 8 | BlackRock Fund Advisors | 648,924 | 7,132,000 | 3.85% | ||
| 9 | VHCP MANAGEMENT II, LLC | 577,831 | 6,350,000 | 3.43% | ||
| 10 | BVF INC/IL | 554,806 | 6,097,000 | 3.29% | ||
| 11 | Cormorant Asset Management, LP | 371,636 | 4,084,000 | 2.20% | ||
| 12 | FRANKLIN RESOURCES INC | 333,500 | 3,665,000 | 1.98% | ||
| 13 | STATE STREET CORP | 275,483 | 3,027,000 | 1.63% | ||
| 14 | NORTHERN TRUST CORP | 234,506 | 2,577,000 | 1.39% | ||
| 15 | Private Advisor Group, LLC | 213,177 | 2,357,000 | 1.27% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 203,920 | 2,241,000 | 1.21% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 201,203 | 2,211,000 | 1.19% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 191,719 | 2,106,000 | 1.14% | ||
| 19 | Opaleye Management Inc. | 170,000 | 1,868,000 | 1.01% | ||
| 20 | Candriam S.C.A. | 155,000 | 1,703,000 | 0.92% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 1,649,000 | 0.89% | ||
| 22 | Montecito Bank & Trust | 146,544 | 1,611,000 | 0.87% | ||
| 23 | CASDIN CAPITAL, LLC | 127,500 | 1,401,000 | 0.76% | ||
| 24 | BANK OF AMERICA CORP /DE/ | 117,990 | 1,297,000 | 0.70% | ||
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 95,132 | 1,046,000 | 0.56% | ||
| 26 | RENAISSANCE TECHNOLOGIES LLC | 91,200 | 1,002,000 | 0.54% | ||
| 27 | Bank of New York Mellon Corp | 86,863 | 955,000 | 0.52% | ||
| 28 | BlackRock Investment Management, LLC | 77,074 | 847,000 | 0.46% | ||
| 29 | Spark Investment Management LLC | 66,700 | 733,000 | 0.40% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,902 | 724,000 | 0.39% | ||
| 31 | VHCP Management, LLC | 64,200 | 706,000 | 0.38% | ||
| 32 | MORGAN STANLEY | 63,776 | 701,000 | 0.38% | ||
| 33 | Vident Investment Advisory, LLC | 63,272 | 695,000 | 0.38% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 53,470 | 588,000 | 0.32% | ||
| 35 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 47,666 | 524,000 | 0.28% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,030 | 462,000 | 0.25% | ||
| 37 | TEACHERS ADVISORS, LLC | 34,961 | 384,000 | 0.21% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 33,186 | 365,000 | 0.20% | ||
| 39 | JPMORGAN CHASE & CO | 28,517 | 313,000 | 0.17% | ||
| 40 | OXFORD ASSET MANAGEMENT LLP | 24,670 | 271,000 | 0.15% | ||
| 41 | Swiss National Bank | 22,500 | 247,000 | 0.13% | ||
| 42 | RUSSELL INVESTMENTS GROUP, LTD. | 21,842 | 243,000 | 0.13% | ||
| 43 | RHUMBLINE ADVISERS | 21,038 | 231,000 | 0.12% | ||
| 44 | NEW YORK STATE COMMON RETIREMENT FUND | 20,900 | 230,000 | 0.12% | ||
| 45 | CITIGROUP INC | 20,658 | 227,000 | 0.12% | ||
| 46 | METROPOLITAN LIFE INSURANCE CO/NY | 17,176 | 189,000 | 0.10% | ||
| 47 | Trexquant Investment LP | 16,900 | 186,000 | 0.10% | ||
| 48 | Squarepoint Ops LLC | 16,360 | 180,000 | 0.10% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,419 | 169,000 | 0.09% | ||
| 50 | WELLS FARGO & COMPANY/MN | 14,677 | 161,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
