| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,403,643 | 112,773,000 | 31.31% | ||
| 2 | CANAAN PARTNERS IX LLC | 4,884,755 | 101,945,000 | 28.30% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 946,022 | 19,743,000 | 5.48% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 749,055 | 15,611,000 | 4.33% | ||
| 5 | Redmile Group, LLC | 738,356 | 14,405,000 | 4.00% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 642,047 | 13,399,000 | 3.72% | ||
| 7 | BVF INC/IL | 608,848 | 12,707,000 | 3.53% | ||
| 8 | VHCP MANAGEMENT II, LLC | 603,031 | 11,642,000 | 3.23% | ||
| 9 | Cormorant Asset Management, LP | 371,023 | 7,743,000 | 2.15% | ||
| 10 | Tekla Capital Management LLC | 328,059 | 6,847,000 | 1.90% | ||
| 11 | PUTNAM INVESTMENTS LLC | 325,000 | 6,783,000 | 1.88% | ||
| 12 | CASDIN CAPITAL, LLC | 321,023 | 6,700,000 | 1.86% | ||
| 13 | FRANKLIN RESOURCES INC | 300,000 | 6,261,000 | 1.74% | ||
| 14 | BlackRock Fund Advisors | 206,926 | 4,319,000 | 1.20% | ||
| 15 | VANGUARD GROUP INC | 199,137 | 4,156,000 | 1.15% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 100,000 | 2,087,000 | 0.58% | ||
| 17 | VHCP Management, LLC | 75,000 | 1,565,000 | 0.43% | ||
| 18 | NORTHERN TRUST CORP | 73,459 | 1,533,000 | 0.43% | ||
| 19 | STATE STREET CORP | 68,079 | 1,421,000 | 0.39% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 58,070 | 1,211,000 | 0.34% | ||
| 21 | Vident Investment Advisory, LLC | 38,502 | 804,000 | 0.22% | ||
| 22 | Informed Momentum Co LLC | 34,856 | 727,000 | 0.20% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 32,441 | 677,000 | 0.19% | ||
| 24 | RUSSELL FRANK CO/ | 28,410 | 591,000 | 0.16% | ||
| 25 | BlackRock Investment Management, LLC | 26,767 | 559,000 | 0.16% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,222 | 485,000 | 0.13% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,571 | 472,000 | 0.13% | ||
| 28 | D. E. Shaw & Co., Inc. | 21,257 | 444,000 | 0.12% | ||
| 29 | Bank of New York Mellon Corp | 18,285 | 382,000 | 0.11% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 17,210 | 359,000 | 0.10% | ||
| 31 | GOLDMAN SACHS GROUP INC | 15,278 | 319,000 | 0.09% | ||
| 32 | Quantitative Systematic Strategies LLC | 14,409 | 300,000 | 0.08% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,200 | 296,000 | 0.08% | ||
| 34 | Candriam S.C.A. | 10,000 | 209,000 | 0.06% | ||
| 35 | TEACHERS ADVISORS, LLC | 7,663 | 160,000 | 0.04% | ||
| 36 | MORGAN STANLEY | 5,902 | 123,000 | 0.03% | ||
| 37 | Nationwide Fund Advisors | 4,613 | 96,000 | 0.03% | ||
| 38 | BLACKROCK ADVISORS LLC | 2,550 | 53,000 | 0.01% | ||
| 39 | STRS OHIO | 2,500 | 52,000 | 0.01% | ||
| 40 | CITIGROUP INC | 2,312 | 48,000 | 0.01% | ||
| 41 | WELLS FARGO & COMPANY/MN | 2,235 | 47,000 | 0.01% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 2,006 | 42,000 | 0.01% | ||
| 43 | DEUTSCHE BANK AG\ | 1,928 | 39,000 | 0.01% | ||
| 44 | Tower Research Capital LLC (TRC) | 1,219 | 25,000 | 0.01% | ||
| 45 | FIFTH THIRD BANCORP | 740 | 15,000 | 0.00% | ||
| 46 | BNP PARIBAS FINANCIAL MARKETS | 688 | 14,359 | 0.00% | ||
| 47 | UBS Group AG | 664 | 14,000 | 0.00% | ||
| 48 | BARCLAYS PLC | 167 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
