| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,443,262 | 85,350,000 | 27.60% | ||
| 2 | CANAAN PARTNERS IX LLC | 4,244,381 | 66,552,000 | 21.52% | ||
| 3 | PUTNAM INVESTMENTS LLC | 1,369,801 | 21,479,000 | 6.95% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 943,433 | 14,793,000 | 4.78% | ||
| 5 | VANGUARD GROUP INC | 784,646 | 12,303,000 | 3.98% | ||
| 6 | Tekla Capital Management LLC | 756,090 | 11,855,000 | 3.83% | ||
| 7 | Redmile Group, LLC | 714,692 | 11,206,000 | 3.62% | ||
| 8 | BVF INC/IL | 591,813 | 9,280,000 | 3.00% | ||
| 9 | VHCP MANAGEMENT II, LLC | 577,831 | 9,060,000 | 2.93% | ||
| 10 | BlackRock Fund Advisors | 557,851 | 8,747,000 | 2.83% | ||
| 11 | Cormorant Asset Management, LP | 371,636 | 5,827,000 | 1.88% | ||
| 12 | FRANKLIN RESOURCES INC | 333,500 | 5,229,000 | 1.69% | ||
| 13 | BLACKROCK ADVISORS LLC | 333,343 | 5,227,000 | 1.69% | ||
| 14 | STATE STREET CORP | 270,887 | 4,248,000 | 1.37% | ||
| 15 | NORTHERN TRUST CORP | 216,324 | 3,391,000 | 1.10% | ||
| 16 | Private Advisor Group, LLC | 212,189 | 3,287,000 | 1.06% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 180,661 | 2,832,000 | 0.92% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 172,888 | 2,711,000 | 0.88% | ||
| 19 | Opaleye Management Inc. | 160,000 | 2,509,000 | 0.81% | ||
| 20 | Candriam S.C.A. | 155,000 | 2,430,000 | 0.79% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 2,352,000 | 0.76% | ||
| 22 | Montecito Bank & Trust | 146,544 | 2,298,000 | 0.74% | ||
| 23 | CASDIN CAPITAL, LLC | 127,500 | 1,999,000 | 0.65% | ||
| 24 | Bank of New York Mellon Corp | 84,165 | 1,320,000 | 0.43% | ||
| 25 | BlackRock Investment Management, LLC | 76,579 | 1,201,000 | 0.39% | ||
| 26 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 71,366 | 1,119,000 | 0.36% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 71,324 | 1,118,000 | 0.36% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 71,166 | 1,116,000 | 0.36% | ||
| 29 | Vident Investment Advisory, LLC | 67,396 | 1,057,000 | 0.34% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 66,088 | 1,036,000 | 0.34% | ||
| 31 | VHCP Management, LLC | 64,200 | 1,007,000 | 0.33% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,130 | 676,000 | 0.22% | ||
| 33 | TEACHERS ADVISORS, LLC | 32,752 | 514,000 | 0.17% | ||
| 34 | Spark Investment Management LLC | 23,904 | 374,000 | 0.12% | ||
| 35 | Swiss National Bank | 22,500 | 353,000 | 0.11% | ||
| 36 | EMERALD ACQUISITION LTD. | 21,842 | 342,000 | 0.11% | ||
| 37 | NEW YORK STATE COMMON RETIREMENT FUND | 20,900 | 328,000 | 0.11% | ||
| 38 | CREDIT SUISSE AG/ | 18,265 | 286,000 | 0.09% | ||
| 39 | RHUMBLINE ADVISERS | 17,226 | 270,000 | 0.09% | ||
| 40 | METROPOLITAN LIFE INSURANCE CO/NY | 17,176 | 269,000 | 0.09% | ||
| 41 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,444 | 242,000 | 0.08% | ||
| 42 | Neuberger Berman Group LLC | 14,300 | 224,000 | 0.07% | ||
| 43 | Virtu KCG Holdings LLC | 13,454 | 211,000 | 0.07% | ||
| 44 | Nationwide Fund Advisors | 12,925 | 203,000 | 0.07% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 11,777 | 184,663 | 0.06% | ||
| 46 | BlackRock Finance, Inc. | 9,344 | 146,000 | 0.05% | ||
| 47 | WELLS FARGO & COMPANY/MN | 7,808 | 122,000 | 0.04% | ||
| 48 | SG Americas Securities, LLC | 7,478 | 117,000 | 0.04% | ||
| 49 | MORGAN STANLEY | 4,735 | 75,000 | 0.02% | ||
| 50 | Legal & General Group Plc | 3,655 | 58,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
