| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,413,165 | 55,295,000 | 28.72% | ||
| 2 | CANAAN PARTNERS IX LLC | 4,244,381 | 43,378,000 | 22.53% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 943,433 | 9,637,000 | 5.01% | ||
| 4 | Tekla Capital Management LLC | 756,090 | 7,723,000 | 4.01% | ||
| 5 | PERCEPTIVE ADVISORS LLC | 742,021 | 7,579,000 | 3.94% | ||
| 6 | Redmile Group, LLC | 733,899 | 7,497,000 | 3.89% | ||
| 7 | BVF INC/IL | 606,138 | 6,192,000 | 3.22% | ||
| 8 | VHCP MANAGEMENT II, LLC | 577,831 | 5,905,000 | 3.07% | ||
| 9 | BLACKROCK ADVISORS LLC | 542,384 | 5,541,000 | 2.88% | ||
| 10 | BlackRock Fund Advisors | 527,248 | 5,386,000 | 2.80% | ||
| 11 | Cormorant Asset Management, LP | 371,636 | 3,796,000 | 1.97% | ||
| 12 | VANGUARD GROUP INC | 371,522 | 3,795,000 | 1.97% | ||
| 13 | FRANKLIN RESOURCES INC | 333,500 | 3,407,000 | 1.77% | ||
| 14 | PUTNAM INVESTMENTS LLC | 325,000 | 3,320,000 | 1.72% | ||
| 15 | STATE STREET CORP | 254,501 | 2,599,000 | 1.35% | ||
| 16 | CASDIN CAPITAL, LLC | 234,179 | 2,392,000 | 1.24% | ||
| 17 | Private Advisor Group, LLC | 219,689 | 2,232,000 | 1.16% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 165,624 | 1,692,000 | 0.88% | ||
| 19 | Opaleye Management Inc. | 160,000 | 1,634,000 | 0.85% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 150,000 | 1,532,000 | 0.80% | ||
| 21 | Montecito Bank & Trust | 146,544 | 1,497,000 | 0.78% | ||
| 22 | NORTHERN TRUST CORP | 99,772 | 1,019,000 | 0.53% | ||
| 23 | BlackRock Investment Management, LLC | 76,710 | 784,000 | 0.41% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 76,114 | 777,000 | 0.40% | ||
| 25 | Bank of New York Mellon Corp | 71,738 | 733,000 | 0.38% | ||
| 26 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 71,366 | 729,000 | 0.38% | ||
| 27 | Vident Investment Advisory, LLC | 67,721 | 692,000 | 0.36% | ||
| 28 | Candriam S.C.A. | 67,000 | 684,000 | 0.36% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 66,368 | 678,000 | 0.35% | ||
| 30 | VHCP Management, LLC | 64,200 | 656,000 | 0.34% | ||
| 31 | EMERALD ACQUISITION LTD. | 43,684 | 446,000 | 0.23% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,830 | 438,000 | 0.23% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,722 | 427,000 | 0.22% | ||
| 34 | TEACHERS ADVISORS, LLC | 32,752 | 335,000 | 0.17% | ||
| 35 | Swiss National Bank | 22,500 | 230,000 | 0.12% | ||
| 36 | NEW YORK STATE COMMON RETIREMENT FUND | 20,900 | 213,000 | 0.11% | ||
| 37 | METROPOLITAN LIFE INSURANCE CO/NY | 17,176 | 175,000 | 0.09% | ||
| 38 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,746 | 161,000 | 0.08% | ||
| 39 | PRICE T ROWE ASSOCIATES INC /MD/ | 15,000 | 153,000 | 0.08% | ||
| 40 | RHUMBLINE ADVISERS | 14,926 | 152,000 | 0.08% | ||
| 41 | MILLENNIUM MANAGEMENT LLC | 14,195 | 145,000 | 0.08% | ||
| 42 | CREDIT SUISSE AG/ | 13,877 | 142,000 | 0.07% | ||
| 43 | Nationwide Fund Advisors | 12,925 | 132,000 | 0.07% | ||
| 44 | AMERICAN INTERNATIONAL GROUP, INC. | 11,759 | 120,118 | 0.06% | ||
| 45 | HARBOURVEST PARTNERS LLC | 10,000 | 102,000 | 0.05% | ||
| 46 | BlackRock Finance, Inc. | 7,585 | 77,000 | 0.04% | ||
| 47 | Legal & General Group Plc | 3,655 | 36,000 | 0.02% | ||
| 48 | Manchester Capital Management LLC | 3,239 | 33,000 | 0.02% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 3,159 | 33,000 | 0.02% | ||
| 50 | DEUTSCHE BANK AG\ | 3,142 | 31,000 | 0.02% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
