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IONIS PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC. Institutional holdings reported to the SEC.

Institutional Holders (2015Q4)
Portfolio Summary: 369 Institutional holders with a total value of $6,541,561,672.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 FMR LLC 17,710,957 1,096,840,000 16.77%
2 Clearbridge Investments, LLC 9,474,704 586,768,000 8.97%
3 VANGUARD GROUP INC 8,250,750 510,968,000 7.81%
4 BAILLIE GIFFORD & CO 8,078,518 500,302,000 7.65%
5 BB BIOTECH AG 6,529,838 404,393,000 6.18%
6 WADDELL & REED FINANCIAL INC 5,770,300 357,355,000 5.46%
7 BlackRock Institutional Trust Company, N.A. 3,014,982 186,718,000 2.85%
8 STATE STREET CORP 2,624,873 162,557,000 2.48%
9 BlackRock Fund Advisors 2,604,537 161,299,000 2.47%
10 FIRST TRUST ADVISORS LP 2,327,482 144,141,000 2.20%
11 FRANKLIN RESOURCES INC 1,791,747 110,964,000 1.70%
12 PINNACLE ASSOCIATES LTD 1,690,263 104,678,000 1.60%
13 PRICE T ROWE ASSOCIATES INC /MD/ 1,400,487 86,732,000 1.33%
14 GOLDMAN SACHS GROUP INC 1,397,232 86,531,000 1.32%
15 OppenheimerFunds, Inc. 1,270,321 78,671,000 1.20%
16 BLACKROCK ADVISORS LLC 1,240,835 76,845,000 1.17%
17 TOCQUEVILLE ASSET MANAGEMENT L.P. 1,111,465 68,833,000 1.05%
18 Apex Capital Management 1,020,096 63,175,000 0.97%
19 NORGES BANK 1,019,236 63,121,000 0.96%
20 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 931,996 57,720,000 0.88%
21 SUSQUEHANNA INTERNATIONAL GROUP, LLP 866,900 53,687,000 0.82% Put
22 BlackRock Group LTD 849,678 52,620,000 0.80%
23 BANK OF AMERICA CORP /DE/ 776,007 48,057,000 0.73%
24 GEODE CAPITAL MANAGEMENT, LLC 728,970 45,117,000 0.69%
25 DEUTSCHE BANK AG\ 696,674 43,142,000 0.66%
26 DOWLING & YAHNKE LLC 676,379 41,888,000 0.64%
27 STIFEL FINANCIAL CORP 598,206 38,686,000 0.59%
28 AQR CAPITAL MANAGEMENT LLC 614,086 38,030,000 0.58%
29 WELLS FARGO & COMPANY/MN 585,927 36,286,000 0.55%
30 Bank of New York Mellon Corp 559,000 34,618,000 0.53%
31 Mitsubishi UFJ Trust & Banking Corp 551,843 34,176,000 0.52%
32 NORTHERN TRUST CORP 539,426 33,407,000 0.51%
33 AMERICAN CENTURY COMPANIES INC 510,253 31,600,000 0.48%
34 RAYMOND JAMES & ASSOCIATES 497,974 30,840,000 0.47%
35 TWO SIGMA INVESTMENTS, LP 462,310 28,631,000 0.44%
36 WELLINGTON MANAGEMENT GROUP LLP 425,702 26,364,000 0.40%
37 NEW YORK STATE COMMON RETIREMENT FUND 405,051 25,085,000 0.38%
38 TWO SIGMA ADVISERS, LP 395,539 24,496,000 0.37%
39 TIAA CREF INVESTMENT MANAGEMENT LLC 381,431 23,622,000 0.36%
40 SUSQUEHANNA INTERNATIONAL GROUP, LLP 366,500 22,697,000 0.35% Call
41 Calamos Advisors LLC 362,025 22,420,000 0.34%
42 Artal Group S.A. 350,000 21,676,000 0.33%
43 CREDIT SUISSE AG/ 341,101 21,124,000 0.32%
44 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 331,053 20,502,000 0.31%
45 AXA S.A. 316,858 19,623,000 0.30%
46 Sumitomo Mitsui Trust Group, Inc. 303,628 18,618,000 0.28%
47 EverPoint Asset Management, LLC 300,000 18,579,000 0.28%
48 Point72 Asset Management, L.P. 297,900 18,449,000 0.28%
49 CHARTWELL INVESTMENT PARTNERS, LLC 297,739 18,439,000 0.28%
50 SUSQUEHANNA INTERNATIONAL GROUP, LLP 297,189 18,405,000 0.28%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.