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IONIS PHARMACEUTICALS INC
IONIS PHARMACEUTICALS INC. Institutional holdings reported to the SEC.

Institutional Holders (2016Q2)
Portfolio Summary: 310 Institutional holders with a total value of $2,635,521,661.
#
Manager Name
Shares
Value ($)
%
Options
Notes
1 FMR LLC 18,117,448 421,955,000 16.01%
2 Clearbridge Investments, LLC 11,267,127 262,411,000 9.96%
3 VANGUARD GROUP INC 8,794,783 204,831,000 7.77%
4 BAILLIE GIFFORD & CO 8,663,711 201,778,000 7.66%
5 BB BIOTECH AG 7,104,838 165,472,000 6.28%
6 WADDELL & REED FINANCIAL INC 5,949,200 138,557,000 5.26%
7 STATE STREET CORP 4,246,911 98,915,000 3.75%
8 BlackRock Institutional Trust Company, N.A. 3,055,995 71,174,000 2.70%
9 BlackRock Fund Advisors 2,800,396 65,221,000 2.47%
10 OppenheimerFunds, Inc. 1,886,451 43,936,000 1.67%
11 AQR CAPITAL MANAGEMENT LLC 1,858,239 43,278,000 1.64%
12 PINNACLE ASSOCIATES LTD 1,680,412 39,137,000 1.48%
13 ALTRINSIC GLOBAL ADVISORS LLC 1,371,376 31,939,000 1.21%
14 PRICE T ROWE ASSOCIATES INC /MD/ 1,340,638 31,223,000 1.18%
15 TOCQUEVILLE ASSET MANAGEMENT L.P. 1,326,120 30,885,000 1.17%
16 DEUTSCHE BANK AG\ 1,109,350 25,833,000 0.98%
17 BRIDGER MANAGEMENT, LLC 1,095,000 25,503,000 0.97% Call
18 FRANKLIN RESOURCES INC 1,084,367 25,253,000 0.96%
19 GOLDMAN SACHS GROUP INC 1,007,006 23,453,000 0.89%
20 Fiera Capital Corp 958,620 22,326,000 0.85%
21 NORGES BANK 936,681 21,815,000 0.83%
22 WELLS FARGO & COMPANY/MN 870,787 20,281,000 0.77%
23 BVF INC/IL 850,000 19,797,000 0.75%
24 LOS ANGELES CAPITAL MANAGEMENT LLC 846,664 19,719,000 0.75%
25 GEODE CAPITAL MANAGEMENT, LLC 793,668 18,475,000 0.70%
26 SUSQUEHANNA INTERNATIONAL GROUP, LLP 726,200 16,913,000 0.64% Put
27 BANK OF AMERICA CORP /DE/ 693,220 16,145,000 0.61%
28 DOWLING & YAHNKE LLC 676,298 15,751,000 0.60%
29 FIRST TRUST ADVISORS LP 675,726 15,738,000 0.60%
30 Mitsubishi UFJ Trust & Banking Corp 646,159 15,049,000 0.57%
31 AMERICAN CENTURY COMPANIES INC 636,805 14,831,000 0.56%
32 STIFEL FINANCIAL CORP 594,308 13,843,000 0.53%
33 BOGLE INVESTMENT MANAGEMENT L P /DE/ 576,970 13,437,000 0.51%
34 NORTHERN TRUST CORP 574,085 13,371,000 0.51%
35 SUSQUEHANNA INTERNATIONAL GROUP, LLP 563,300 13,119,000 0.50% Call
36 Bank of New York Mellon Corp 561,835 13,085,000 0.50%
37 RAYMOND JAMES & ASSOCIATES 526,185 12,255,000 0.46%
38 MORGAN STANLEY 504,861 11,759,000 0.45%
39 BlackRock Group LTD 494,694 11,522,000 0.44%
40 JANUS HENDERSON INVESTORS US LLC 490,700 11,428,000 0.43%
41 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 470,805 10,965,000 0.42%
42 WELLINGTON MANAGEMENT GROUP LLP 416,469 9,699,000 0.37%
43 NEW YORK STATE COMMON RETIREMENT FUND 410,352 9,557,000 0.36%
44 SCOUT INVESTMENTS, INC. 406,145 9,459,000 0.36%
45 SUSQUEHANNA INTERNATIONAL GROUP, LLP 397,486 9,258,000 0.35%
46 WILLIAM HARRIS INVESTORS INC 380,018 8,850,000 0.34%
47 TIAA CREF INVESTMENT MANAGEMENT LLC 362,639 8,446,000 0.32%
48 AXA S.A. 352,549 8,211,000 0.31%
49 Invesco Ltd. 347,935 8,104,000 0.31%
50 Motley Fool Wealth Management, LLC 339,197 7,900,000 0.30%
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From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.