| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 18,137,854 | 664,571,000 | 16.53% | ||
| 2 | Clearbridge Investments, LLC | 10,828,375 | 396,752,000 | 9.87% | ||
| 3 | VANGUARD GROUP INC | 8,793,152 | 322,181,000 | 8.02% | ||
| 4 | BAILLIE GIFFORD & CO | 8,475,347 | 310,536,000 | 7.73% | ||
| 5 | BB BIOTECH AG | 7,163,172 | 262,459,000 | 6.53% | ||
| 6 | WADDELL & REED FINANCIAL INC | 5,813,400 | 213,003,000 | 5.30% | ||
| 7 | STATE STREET CORP | 3,584,604 | 131,339,000 | 3.27% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 3,092,697 | 113,316,000 | 2.82% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 2,983,492 | 109,315,000 | 2.72% | ||
| 10 | BlackRock Fund Advisors | 2,878,111 | 105,454,000 | 2.62% | ||
| 11 | OppenheimerFunds, Inc. | 2,193,626 | 80,374,000 | 2.00% | ||
| 12 | PINNACLE ASSOCIATES LTD | 1,656,017 | 60,676,000 | 1.51% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 1,606,306 | 58,855,000 | 1.46% | ||
| 14 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 1,137,549 | 41,680,000 | 1.04% | ||
| 15 | GOLDMAN SACHS GROUP INC | 1,060,138 | 38,843,000 | 0.97% | ||
| 16 | FRANKLIN RESOURCES INC | 1,049,714 | 38,464,000 | 0.96% | ||
| 17 | ALTRINSIC GLOBAL ADVISORS LLC | 1,033,481 | 37,867,000 | 0.94% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,033,100 | 37,853,000 | 0.94% | ||
| 19 | FIRST TRUST ADVISORS LP | 995,094 | 36,460,000 | 0.91% | ||
| 20 | Fiera Capital Corp | 931,874 | 34,144,000 | 0.85% | ||
| 21 | WELLS FARGO & COMPANY/MN | 847,912 | 31,067,000 | 0.77% | ||
| 22 | NORGES BANK | 871,794 | 30,508,000 | 0.76% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 818,128 | 29,976,000 | 0.75% | ||
| 24 | LOS ANGELES CAPITAL MANAGEMENT LLC | 807,729 | 29,595,000 | 0.74% | ||
| 25 | DEUTSCHE BANK AG\ | 787,515 | 28,851,000 | 0.72% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 699,300 | 25,622,000 | 0.64% | Put | |
| 27 | DOWLING & YAHNKE LLC | 676,472 | 24,786,000 | 0.62% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 665,765 | 24,394,000 | 0.61% | ||
| 29 | PFM Health Sciences, LP | 649,716 | 23,806,000 | 0.59% | ||
| 30 | AMERICAN CENTURY COMPANIES INC | 635,195 | 23,274,000 | 0.58% | ||
| 31 | STIFEL FINANCIAL CORP | 560,696 | 20,565,000 | 0.51% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 531,000 | 19,456,000 | 0.48% | Call | |
| 33 | RAYMOND JAMES & ASSOCIATES | 526,179 | 19,279,000 | 0.48% | ||
| 34 | NORTHERN TRUST CORP | 508,484 | 18,631,000 | 0.46% | ||
| 35 | Bank of New York Mellon Corp | 487,869 | 17,875,000 | 0.44% | ||
| 36 | Livforsakringsbolaget Skandia, Omsesidigt | 138,621 | 15,448,000 | 0.38% | ||
| 37 | AQR CAPITAL MANAGEMENT LLC | 407,582 | 14,934,000 | 0.37% | ||
| 38 | Mitsubishi UFJ Trust & Banking Corp | 387,820 | 14,210,000 | 0.35% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 386,252 | 14,152,000 | 0.35% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 383,160 | 14,039,000 | 0.35% | ||
| 41 | AXA S.A. | 382,415 | 14,012,000 | 0.35% | ||
| 42 | CITADEL ADVISORS LLC | 348,263 | 12,760,000 | 0.32% | ||
| 43 | Motley Fool Wealth Management, LLC | 332,525 | 12,184,000 | 0.30% | ||
| 44 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 327,871 | 12,013,000 | 0.30% | ||
| 45 | WILLIAM HARRIS INVESTORS INC | 320,018 | 11,726,000 | 0.29% | ||
| 46 | SCOUT INVESTMENTS, INC. | 283,936 | 10,403,000 | 0.26% | ||
| 47 | RENAISSANCE TECHNOLOGIES LLC | 274,814 | 10,069,000 | 0.25% | ||
| 48 | Granahan Investment Management, LLC | 273,900 | 10,036,000 | 0.25% | ||
| 49 | CREDIT SUISSE AG/ | 270,457 | 9,909,000 | 0.25% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 270,130 | 9,898,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
