| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 17,792,097 | 720,580,000 | 16.67% | ||
| 2 | Clearbridge Investments, LLC | 11,124,548 | 450,544,000 | 10.42% | ||
| 3 | VANGUARD GROUP INC | 8,445,611 | 342,047,000 | 7.91% | ||
| 4 | BAILLIE GIFFORD & CO | 8,283,738 | 335,492,000 | 7.76% | ||
| 5 | BB BIOTECH AG | 6,779,838 | 274,583,000 | 6.35% | ||
| 6 | WADDELL & REED FINANCIAL INC | 5,801,100 | 234,944,000 | 5.43% | ||
| 7 | STATE STREET CORP | 3,037,388 | 123,010,000 | 2.85% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 3,023,694 | 122,460,000 | 2.83% | ||
| 9 | BlackRock Fund Advisors | 2,754,474 | 111,556,000 | 2.58% | ||
| 10 | FRANKLIN RESOURCES INC | 1,771,447 | 71,743,000 | 1.66% | ||
| 11 | PINNACLE ASSOCIATES LTD | 1,697,378 | 68,744,000 | 1.59% | ||
| 12 | OppenheimerFunds, Inc. | 1,449,191 | 58,693,000 | 1.36% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,314,228 | 53,226,000 | 1.23% | ||
| 14 | BLACKROCK ADVISORS LLC | 1,128,642 | 45,710,000 | 1.06% | ||
| 15 | FIRST TRUST ADVISORS LP | 1,091,692 | 44,214,000 | 1.02% | ||
| 16 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 1,087,554 | 44,046,000 | 1.02% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 1,078,089 | 43,663,000 | 1.01% | ||
| 18 | Apex Capital Management | 1,036,620 | 41,983,000 | 0.97% | ||
| 19 | NORGES BANK | 1,019,236 | 41,279,000 | 0.95% | ||
| 20 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 967,206 | 39,172,000 | 0.91% | ||
| 21 | BANK OF AMERICA CORP /DE/ | 876,078 | 35,481,000 | 0.82% | ||
| 22 | WELLS FARGO & COMPANY/MN | 847,168 | 34,310,000 | 0.79% | ||
| 23 | BlackRock Group LTD | 761,363 | 30,836,000 | 0.71% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 760,951 | 30,802,000 | 0.71% | ||
| 25 | DEUTSCHE BANK AG\ | 758,626 | 30,721,000 | 0.71% | ||
| 26 | GOLDMAN SACHS GROUP INC | 677,323 | 27,432,000 | 0.63% | ||
| 27 | DOWLING & YAHNKE LLC | 676,339 | 27,392,000 | 0.63% | ||
| 28 | Invesco Ltd. | 654,875 | 26,523,000 | 0.61% | ||
| 29 | ALTRINSIC GLOBAL ADVISORS LLC | 617,886 | 25,024,000 | 0.58% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 572,500 | 23,186,000 | 0.54% | Put | |
| 31 | Bank of New York Mellon Corp | 565,171 | 22,890,000 | 0.53% | ||
| 32 | AMERICAN CENTURY COMPANIES INC | 559,818 | 22,673,000 | 0.52% | ||
| 33 | Mitsubishi UFJ Trust & Banking Corp | 558,782 | 22,631,000 | 0.52% | ||
| 34 | NORTHERN TRUST CORP | 549,914 | 22,271,000 | 0.52% | ||
| 35 | RAYMOND JAMES & ASSOCIATES | 513,383 | 20,792,000 | 0.48% | ||
| 36 | SECTORAL ASSET MANAGEMENT INC | 433,300 | 17,549,000 | 0.41% | ||
| 37 | WELLINGTON MANAGEMENT GROUP LLP | 427,109 | 17,298,000 | 0.40% | ||
| 38 | NEW YORK STATE COMMON RETIREMENT FUND | 411,458 | 16,664,000 | 0.39% | ||
| 39 | AQR CAPITAL MANAGEMENT LLC | 393,235 | 15,926,000 | 0.37% | ||
| 40 | CREDIT SUISSE AG/ | 377,278 | 15,279,000 | 0.35% | ||
| 41 | AXA S.A. | 367,016 | 14,864,000 | 0.34% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 366,258 | 14,834,000 | 0.34% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 363,996 | 14,742,000 | 0.34% | ||
| 44 | Artal Group S.A. | 350,000 | 14,175,000 | 0.33% | ||
| 45 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 335,242 | 13,578,000 | 0.31% | ||
| 46 | CHARTWELL INVESTMENT PARTNERS, LLC | 327,220 | 13,252,000 | 0.31% | ||
| 47 | Sumitomo Mitsui Trust Group, Inc. | 324,858 | 13,157,000 | 0.30% | ||
| 48 | WILLIAM HARRIS INVESTORS INC | 324,462 | 13,141,000 | 0.30% | ||
| 49 | BLUE JAY CAPITAL MANAGEMENT, LLC | 318,490 | 12,899,000 | 0.30% | ||
| 50 | Swiss National Bank | 312,100 | 12,114,000 | 0.28% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
