| 1 |
FMR LLC |
3,936,446 |
57,709,000 |
42.05% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,467,089 |
21,509,000 |
15.67% |
|
|
| 3 |
Cormorant Asset Management, LP |
753,388 |
11,045,000 |
8.05% |
|
|
| 4 |
PFM Health Sciences, LP |
698,694 |
10,243,000 |
7.46% |
|
|
| 5 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
582,603 |
8,541,000 |
6.22% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
502,903 |
7,372,000 |
5.37% |
|
|
| 7 |
CASDIN CAPITAL, LLC |
403,872 |
5,921,000 |
4.31% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
375,000 |
5,498,000 |
4.01% |
|
|
| 9 |
BlackRock Fund Advisors |
169,676 |
2,487,000 |
1.81% |
|
|
| 10 |
NORTHERN TRUST CORP |
62,886 |
922,000 |
0.67% |
|
|
| 11 |
VANGUARD GROUP INC |
58,858 |
863,000 |
0.63% |
|
|
| 12 |
GEODE CAPITAL MANAGEMENT, LLC |
53,174 |
779,000 |
0.57% |
|
|
| 13 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
52,600 |
771,000 |
0.56% |
|
|
| 14 |
STATE STREET CORP |
48,835 |
714,000 |
0.52% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
33,011 |
484,000 |
0.35% |
|
|
| 16 |
Fernwood Investment Management, LLC |
30,000 |
440,000 |
0.32% |
|
|
| 17 |
D. E. Shaw & Co., Inc. |
25,289 |
371,000 |
0.27% |
|
|
| 18 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,200 |
282,000 |
0.21% |
|
|
| 19 |
Partner Investment Management, L.P. |
15,603 |
229,000 |
0.17% |
|
|
| 20 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,635 |
171,000 |
0.12% |
|
|
| 21 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
11,600 |
170,000 |
0.12% |
|
|
| 22 |
BlackRock Investment Management, LLC |
10,271 |
151,000 |
0.11% |
|
|
| 23 |
WELLS FARGO & COMPANY/MN |
10,291 |
150,000 |
0.11% |
|
|
| 24 |
NORGES BANK |
6,700 |
98,000 |
0.07% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
6,378 |
94,000 |
0.07% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
5,310 |
76,000 |
0.06% |
|
|
| 27 |
Nationwide Fund Advisors |
3,310 |
49,000 |
0.04% |
|
|
| 28 |
STRS OHIO |
2,000 |
29,000 |
0.02% |
|
|
| 29 |
BLACKROCK ADVISORS LLC |
1,897 |
28,000 |
0.02% |
|
|
| 30 |
CITIGROUP INC |
1,910 |
28,000 |
0.02% |
|
|
| 31 |
BNP PARIBAS FINANCIAL MARKETS |
559 |
8,195 |
0.01% |
|
|
| 32 |
Tower Research Capital LLC (TRC) |
262 |
4,000 |
0.00% |
|
|
| 33 |
MORGAN STANLEY |
131 |
2,000 |
0.00% |
|
|
| 34 |
BARCLAYS PLC |
135 |
2,000 |
0.00% |
|
|
| 35 |
BANK OF AMERICA CORP /DE/ |
151 |
2,000 |
0.00% |
|
|
