| 1 |
FMR LLC |
3,936,270 |
42,158,000 |
39.53% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,593,487 |
17,067,000 |
16.00% |
|
|
| 3 |
PFM Health Sciences, LP |
764,632 |
8,189,000 |
7.68% |
|
|
| 4 |
Cormorant Asset Management, LP |
753,388 |
8,069,000 |
7.57% |
|
|
| 5 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
609,542 |
6,528,000 |
6.12% |
|
|
| 6 |
PERCEPTIVE ADVISORS LLC |
502,894 |
5,385,000 |
5.05% |
|
|
| 7 |
CASDIN CAPITAL, LLC |
475,350 |
5,091,000 |
4.77% |
|
|
| 8 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
374,800 |
4,014,000 |
3.76% |
|
|
| 9 |
JPMORGAN CHASE & CO |
244,037 |
2,613,000 |
2.45% |
|
|
| 10 |
BlackRock Fund Advisors |
161,129 |
1,726,000 |
1.62% |
|
|
| 11 |
VANGUARD GROUP INC |
136,369 |
1,461,000 |
1.37% |
|
|
| 12 |
STATE STREET CORP |
64,435 |
690,000 |
0.65% |
|
|
| 13 |
GEODE CAPITAL MANAGEMENT, LLC |
63,701 |
682,000 |
0.64% |
|
|
| 14 |
NORTHERN TRUST CORP |
61,783 |
661,000 |
0.62% |
|
|
| 15 |
BlackRock Institutional Trust Company, N.A. |
34,386 |
368,000 |
0.35% |
|
|
| 16 |
Fernwood Investment Management, LLC |
28,000 |
300,000 |
0.28% |
|
|
| 17 |
BlackRock Investment Management, LLC |
20,183 |
216,000 |
0.20% |
|
|
| 18 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,506 |
209,000 |
0.20% |
|
|
| 19 |
Partner Investment Management, L.P. |
15,500 |
166,000 |
0.16% |
|
|
| 20 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
13,451 |
144,000 |
0.14% |
|
|
| 21 |
MILLENNIUM MANAGEMENT LLC |
13,135 |
141,000 |
0.13% |
|
|
| 22 |
Bank of New York Mellon Corp |
11,642 |
125,000 |
0.12% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
7,773 |
83,000 |
0.08% |
|
|
| 24 |
BARCLAYS PLC |
7,698 |
77,000 |
0.07% |
|
|
| 25 |
TEACHERS ADVISORS, LLC |
6,378 |
68,000 |
0.06% |
|
|
| 26 |
NEW YORK STATE COMMON RETIREMENT FUND |
5,000 |
54,000 |
0.05% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
5,026 |
54,000 |
0.05% |
|
|
| 28 |
CITIGROUP INC |
5,104 |
54,000 |
0.05% |
|
|
| 29 |
Nationwide Fund Advisors |
4,444 |
48,000 |
0.05% |
|
|
| 30 |
NORGES BANK |
4,080 |
44,000 |
0.04% |
|
|
| 31 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,658 |
39,000 |
0.04% |
|
|
| 32 |
Stanford Investment Group, Inc. |
3,200 |
34,000 |
0.03% |
|
|
| 33 |
STRS OHIO |
2,000 |
21,000 |
0.02% |
|
|
| 34 |
BLACKROCK ADVISORS LLC |
1,897 |
20,000 |
0.02% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,816 |
19,000 |
0.02% |
|
|
| 36 |
DEUTSCHE BANK AG\ |
961 |
10,000 |
0.01% |
|
|
| 37 |
MORGAN STANLEY |
800 |
9,000 |
0.01% |
|
|
| 38 |
Tower Research Capital LLC (TRC) |
192 |
2,000 |
0.00% |
|
|
| 39 |
BlackRock Finance, Inc. |
116 |
1,000 |
0.00% |
|
|
