| 1 |
FMR LLC |
3,889,770 |
63,559,000 |
27.24% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
3,125,078 |
51,063,000 |
21.88% |
|
|
| 3 |
Cormorant Asset Management, LP |
1,605,790 |
26,239,000 |
11.24% |
|
|
| 4 |
PFM Health Sciences, LP |
1,193,037 |
19,494,000 |
8.35% |
|
|
| 5 |
PERCEPTIVE ADVISORS LLC |
634,894 |
10,374,000 |
4.45% |
|
|
| 6 |
VANGUARD GROUP INC |
529,110 |
8,646,000 |
3.71% |
|
|
| 7 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
499,800 |
8,167,000 |
3.50% |
|
|
| 8 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
412,698 |
6,743,000 |
2.89% |
|
|
| 9 |
BlackRock Fund Advisors |
313,473 |
5,122,000 |
2.20% |
|
|
| 10 |
JPMORGAN CHASE & CO |
172,250 |
2,814,000 |
1.21% |
|
|
| 11 |
CASDIN CAPITAL, LLC |
160,000 |
2,614,000 |
1.12% |
|
|
| 12 |
STATE STREET CORP |
143,580 |
2,347,000 |
1.01% |
|
|
| 13 |
NORTHERN TRUST CORP |
134,117 |
2,192,000 |
0.94% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
131,385 |
2,147,000 |
0.92% |
|
|
| 15 |
MARSHALL WACE, LLP |
100,000 |
1,634,000 |
0.70% |
|
|
| 16 |
BAKER BROS. ADVISORS LP |
100,000 |
1,634,000 |
0.70% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
97,802 |
1,598,000 |
0.68% |
|
|
| 18 |
SPHERA FUNDS MANAGEMENT LTD. |
83,240 |
1,360,000 |
0.58% |
|
|
| 19 |
MILLENNIUM MANAGEMENT LLC |
81,556 |
1,333,000 |
0.57% |
|
|
| 20 |
MONASHEE INVESTMENT MANAGEMENT LLC |
65,000 |
1,062,000 |
0.46% |
|
PRN |
| 21 |
DIALECTIC CAPITAL MANAGEMENT, LP |
60,200 |
984,000 |
0.42% |
|
|
| 22 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
56,100 |
917,000 |
0.39% |
|
|
| 23 |
MOORE CAPITAL MANAGEMENT, LP |
50,000 |
817,000 |
0.35% |
|
|
| 24 |
Informed Momentum Co LLC |
45,794 |
748,000 |
0.32% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
44,981 |
735,000 |
0.31% |
|
|
| 26 |
BlackRock Investment Management, LLC |
42,280 |
691,000 |
0.30% |
|
|
| 27 |
Spark Investment Management LLC |
39,800 |
650,000 |
0.28% |
|
|
| 28 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
39,130 |
640,000 |
0.27% |
|
|
| 29 |
EMERALD ACQUISITION LTD. |
38,792 |
634,000 |
0.27% |
|
|
| 30 |
Fernwood Investment Management, LLC |
32,000 |
523,000 |
0.22% |
|
|
| 31 |
Bank of New York Mellon Corp |
29,990 |
491,000 |
0.21% |
|
|
| 32 |
Laurion Capital Management LP |
29,347 |
480,000 |
0.21% |
|
|
| 33 |
VICTORY CAPITAL MANAGEMENT INC |
27,180 |
444,000 |
0.19% |
|
|
| 34 |
Partner Investment Management, L.P. |
25,498 |
417,000 |
0.18% |
|
|
| 35 |
FIDUCIARY TRUST CO |
25,000 |
409,000 |
0.18% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
23,699 |
387,000 |
0.17% |
|
|
| 37 |
TUDOR INVESTMENT CORP ET AL |
20,000 |
327,000 |
0.14% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
19,803 |
324,000 |
0.14% |
|
|
| 39 |
CREDIT SUISSE AG/ |
17,480 |
285,000 |
0.12% |
|
|
| 40 |
D. E. Shaw & Co., Inc. |
15,819 |
258,000 |
0.11% |
|
|
| 41 |
TWO SIGMA INVESTMENTS, LP |
11,879 |
194,000 |
0.08% |
|
|
| 42 |
NEW YORK STATE COMMON RETIREMENT FUND |
11,693 |
191,000 |
0.08% |
|
|
| 43 |
RENAISSANCE TECHNOLOGIES LLC |
11,100 |
181,000 |
0.08% |
|
|
| 44 |
METROPOLITAN LIFE INSURANCE CO/NY |
9,724 |
159,000 |
0.07% |
|
|
| 45 |
NORGES BANK |
10,000 |
156,000 |
0.07% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
8,783 |
143,000 |
0.06% |
|
|
| 47 |
BARCLAYS PLC |
8,040 |
132,000 |
0.06% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
7,700 |
125,000 |
0.05% |
|
|
| 49 |
Nationwide Fund Advisors |
7,138 |
117,000 |
0.05% |
|
|
| 50 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,488 |
106,014 |
0.05% |
|
|
