| 1 |
FMR LLC |
3,758,770 |
46,609,000 |
37.92% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
1,628,083 |
20,188,000 |
16.43% |
|
|
| 3 |
PFM Health Sciences, LP |
838,810 |
10,401,000 |
8.46% |
|
|
| 4 |
Cormorant Asset Management, LP |
758,290 |
9,403,000 |
7.65% |
|
|
| 5 |
PERCEPTIVE ADVISORS LLC |
502,894 |
6,235,000 |
5.07% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
374,800 |
4,648,000 |
3.78% |
|
|
| 7 |
JPMORGAN CHASE & CO |
350,725 |
4,349,000 |
3.54% |
|
|
| 8 |
VANGUARD GROUP INC |
314,800 |
3,904,000 |
3.18% |
|
|
| 9 |
BlackRock Fund Advisors |
290,293 |
3,600,000 |
2.93% |
|
|
| 10 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
204,703 |
2,538,000 |
2.07% |
|
|
| 11 |
CASDIN CAPITAL, LLC |
179,029 |
2,220,000 |
1.81% |
|
|
| 12 |
STATE STREET CORP |
119,178 |
1,479,000 |
1.20% |
|
|
| 13 |
NORTHERN TRUST CORP |
110,686 |
1,372,000 |
1.12% |
|
|
| 14 |
BlackRock Institutional Trust Company, N.A. |
83,989 |
1,041,000 |
0.85% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
65,496 |
812,000 |
0.66% |
|
|
| 16 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
47,185 |
585,000 |
0.48% |
|
|
| 17 |
BlackRock Investment Management, LLC |
42,352 |
525,000 |
0.43% |
|
|
| 18 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
28,658 |
356,000 |
0.29% |
|
|
| 19 |
Fernwood Investment Management, LLC |
28,000 |
347,000 |
0.28% |
|
|
| 20 |
FIDUCIARY TRUST CO |
25,000 |
310,000 |
0.25% |
|
|
| 21 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
23,599 |
293,000 |
0.24% |
|
|
| 22 |
Bank of New York Mellon Corp |
21,503 |
267,000 |
0.22% |
|
|
| 23 |
TEACHERS ADVISORS, LLC |
18,223 |
226,000 |
0.18% |
|
|
| 24 |
Partner Investment Management, L.P. |
16,187 |
201,000 |
0.16% |
|
|
| 25 |
Spark Investment Management LLC |
12,100 |
150,000 |
0.12% |
|
|
| 26 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
9,033 |
112,000 |
0.09% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
7,700 |
96,000 |
0.08% |
|
|
| 28 |
BARCLAYS PLC |
7,698 |
95,000 |
0.08% |
|
|
| 29 |
Nationwide Fund Advisors |
7,138 |
89,000 |
0.07% |
|
|
| 30 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,650 |
82,000 |
0.07% |
|
|
| 31 |
AMERICAN INTERNATIONAL GROUP, INC. |
6,479 |
80,340 |
0.07% |
|
|
| 32 |
STRS OHIO |
3,700 |
45,000 |
0.04% |
|
|
| 33 |
Tortoise Investment Management, LLC |
3,398 |
42,000 |
0.03% |
|
|
| 34 |
Stanford Investment Group, Inc. |
3,200 |
40,000 |
0.03% |
|
|
| 35 |
BLACKROCK ADVISORS LLC |
3,242 |
40,000 |
0.03% |
|
|
| 36 |
Legal & General Group Plc |
2,071 |
26,000 |
0.02% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
1,720 |
21,000 |
0.02% |
|
|
| 38 |
Creative Planning |
1,600 |
20,000 |
0.02% |
|
|
| 39 |
Tower Research Capital LLC (TRC) |
1,538 |
19,000 |
0.02% |
|
|
| 40 |
CITIGROUP INC |
1,134 |
14,000 |
0.01% |
|
|
| 41 |
UBS Group AG |
651 |
8,000 |
0.01% |
|
|
| 42 |
BlackRock Finance, Inc. |
417 |
5,000 |
0.00% |
|
|
| 43 |
BNP PARIBAS FINANCIAL MARKETS |
401 |
4,972 |
0.00% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
213 |
3,000 |
0.00% |
|
|
| 45 |
IFP ADVISORS, INC |
200 |
2,000 |
0.00% |
|
|
| 46 |
WOLVERINE TRADING LP /BD |
23 |
286 |
0.00% |
|
|
