| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,889,770 | 50,373,000 | 25.83% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,804,966 | 36,324,000 | 18.62% | ||
| 3 | PFM Health Sciences, LP | 1,524,585 | 19,743,000 | 10.12% | ||
| 4 | Cormorant Asset Management, LP | 1,445,090 | 18,714,000 | 9.59% | ||
| 5 | VANGUARD GROUP INC | 630,192 | 8,161,000 | 4.18% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 624,694 | 8,089,000 | 4.15% | ||
| 7 | MILLENNIUM MANAGEMENT LLC | 546,394 | 7,076,000 | 3.63% | ||
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 424,800 | 5,501,000 | 2.82% | ||
| 9 | BlackRock Fund Advisors | 409,775 | 5,307,000 | 2.72% | ||
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | 307,866 | 3,987,000 | 2.04% | ||
| 11 | CASDIN CAPITAL, LLC | 265,000 | 3,432,000 | 1.76% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 184,833 | 2,394,000 | 1.23% | ||
| 13 | STATE STREET CORP | 178,189 | 2,307,000 | 1.18% | ||
| 14 | JPMORGAN CHASE & CO | 170,150 | 2,203,000 | 1.13% | ||
| 15 | NORTHERN TRUST CORP | 169,315 | 2,193,000 | 1.12% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 121,673 | 1,575,000 | 0.81% | ||
| 17 | MARSHALL WACE, LLP | 121,304 | 1,571,000 | 0.81% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 112,308 | 1,454,000 | 0.75% | ||
| 19 | BAKER BROS. ADVISORS LP | 100,000 | 1,295,000 | 0.66% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 83,240 | 1,078,000 | 0.55% | ||
| 21 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 81,650 | 1,057,000 | 0.54% | ||
| 22 | NORGES BANK | 67,142 | 869,000 | 0.45% | ||
| 23 | Bank of New York Mellon Corp | 48,136 | 623,000 | 0.32% | ||
| 24 | HARBOURVEST PARTNERS LLC | 44,145 | 572,000 | 0.29% | ||
| 25 | Fernwood Investment Management, LLC | 42,996 | 557,000 | 0.29% | ||
| 26 | BlackRock Investment Management, LLC | 42,761 | 554,000 | 0.28% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 41,356 | 536,000 | 0.27% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,286 | 535,000 | 0.27% | ||
| 29 | WELLS FARGO & COMPANY/MN | 39,923 | 517,000 | 0.27% | ||
| 30 | MORGAN STANLEY | 39,728 | 514,000 | 0.26% | ||
| 31 | Partner Investment Management, L.P. | 32,496 | 421,000 | 0.22% | ||
| 32 | FIDUCIARY TRUST CO | 28,554 | 370,000 | 0.19% | ||
| 33 | TEACHERS ADVISORS, LLC | 28,145 | 364,000 | 0.19% | ||
| 34 | VICTORY CAPITAL MANAGEMENT INC | 27,180 | 352,000 | 0.18% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,499 | 343,000 | 0.18% | ||
| 36 | Swiss National Bank | 25,290 | 328,000 | 0.17% | ||
| 37 | HAMILTON LANE ADVISORS LLC | 21,854 | 283,000 | 0.15% | ||
| 38 | CREDIT SUISSE AG/ | 20,093 | 260,000 | 0.13% | ||
| 39 | CITADEL ADVISORS LLC | 19,437 | 252,000 | 0.13% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 19,237 | 249,000 | 0.13% | ||
| 41 | VIRTUS ETF ADVISERS LLC | 18,884 | 245,000 | 0.13% | ||
| 42 | Trexquant Investment LP | 16,200 | 210,000 | 0.11% | ||
| 43 | GOLDMAN SACHS GROUP INC | 15,656 | 203,000 | 0.10% | ||
| 44 | CITIGROUP INC | 13,065 | 169,000 | 0.09% | ||
| 45 | Squarepoint Ops LLC | 12,934 | 167,000 | 0.09% | ||
| 46 | RHUMBLINE ADVISERS | 11,858 | 154,000 | 0.08% | ||
| 47 | NEW YORK STATE COMMON RETIREMENT FUND | 11,693 | 151,000 | 0.08% | ||
| 48 | A.R.T. Advisors, LLC | 11,500 | 148,000 | 0.08% | ||
| 49 | ABERDEEN ASSET MANAGEMENT PLC/UK | 11,098 | 144,000 | 0.07% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,715 | 126,000 | 0.06% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
