| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,268,013 | 42,974,000 | 21.80% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 3,154,734 | 41,485,000 | 21.04% | ||
| 3 | PFM Health Sciences, LP | 1,538,507 | 20,231,000 | 10.26% | ||
| 4 | Cormorant Asset Management, LP | 1,130,000 | 14,860,000 | 7.54% | ||
| 5 | VANGUARD GROUP INC | 686,119 | 9,022,000 | 4.58% | ||
| 6 | BlackRock Finance, Inc. | 648,098 | 8,523,000 | 4.32% | ||
| 7 | PERCEPTIVE ADVISORS LLC | 624,694 | 8,214,000 | 4.17% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 497,744 | 6,545,000 | 3.32% | ||
| 9 | DEERFIELD MANAGEMENT COMPANY, L.P. | 424,800 | 5,586,000 | 2.83% | ||
| 10 | CASDIN CAPITAL, LLC | 265,000 | 3,485,000 | 1.77% | ||
| 11 | DRIEHAUS CAPITAL MANAGEMENT LLC | 262,800 | 3,456,000 | 1.75% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 235,583 | 3,098,000 | 1.57% | ||
| 13 | JPMORGAN CHASE & CO | 234,167 | 3,080,000 | 1.56% | ||
| 14 | STATE STREET CORP | 198,048 | 2,608,000 | 1.32% | ||
| 15 | NORTHERN TRUST CORP | 153,939 | 2,024,000 | 1.03% | ||
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 134,730 | 1,771,000 | 0.90% | ||
| 17 | MARSHALL WACE ASIA LTD | 121,304 | 1,577,000 | 0.80% | ||
| 18 | MARSHALL WACE NORTH AMERICA, L.P. | 121,304 | 1,577,000 | 0.80% | ||
| 19 | Point72 Asset Management, L.P. | 117,537 | 1,546,000 | 0.78% | ||
| 20 | BAKER BROS. ADVISORS LP | 100,000 | 1,315,000 | 0.67% | ||
| 21 | HARBOURVEST PARTNERS LLC | 95,519 | 1,256,000 | 0.64% | ||
| 22 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 79,265 | 1,042,000 | 0.53% | ||
| 23 | TFS CAPITAL LLC | 71,059 | 934,000 | 0.47% | ||
| 24 | Bank of New York Mellon Corp | 56,605 | 744,000 | 0.38% | ||
| 25 | GOLDMAN SACHS GROUP INC | 56,400 | 742,000 | 0.38% | ||
| 26 | Hudson Bay Capital Management LP | 52,484 | 690,000 | 0.35% | ||
| 27 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 43,680 | 575,000 | 0.29% | ||
| 28 | Fernwood Investment Management, LLC | 43,323 | 570,000 | 0.29% | ||
| 29 | VICTORY CAPITAL MANAGEMENT INC | 40,535 | 533,000 | 0.27% | ||
| 30 | Trexquant Investment LP | 37,987 | 500,000 | 0.25% | ||
| 31 | HAMILTON LANE ADVISORS LLC | 37,287 | 490,000 | 0.25% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 34,456 | 453,000 | 0.23% | ||
| 33 | DEUTSCHE BANK AG\ | 32,552 | 427,000 | 0.22% | ||
| 34 | Partner Investment Management, L.P. | 30,957 | 407,000 | 0.21% | ||
| 35 | FIDUCIARY TRUST CO | 28,554 | 375,000 | 0.19% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,899 | 341,000 | 0.17% | ||
| 37 | Jasper Ridge Partners, L.P. | 25,686 | 338,000 | 0.17% | ||
| 38 | Swiss National Bank | 25,290 | 333,000 | 0.17% | ||
| 39 | TEACHERS ADVISORS, LLC | 21,901 | 288,000 | 0.15% | ||
| 40 | VIRTUS ETF ADVISERS LLC | 20,886 | 275,000 | 0.14% | ||
| 41 | ABERDEEN ASSET MANAGEMENT PLC/UK | 20,549 | 270,000 | 0.14% | ||
| 42 | Dynamic Technology Lab Private Ltd | 20,458 | 269,000 | 0.14% | ||
| 43 | MORGAN STANLEY | 19,968 | 262,000 | 0.13% | ||
| 44 | WELLS FARGO & COMPANY/MN | 18,084 | 238,000 | 0.12% | ||
| 45 | HERSHEY TRUST CO | 15,919 | 209,000 | 0.11% | ||
| 46 | Daiwa SB Investments Ltd. | 12,965 | 170,000 | 0.09% | ||
| 47 | RHUMBLINE ADVISERS | 12,716 | 167,000 | 0.08% | ||
| 48 | Hutchin Hill Capital, LP | 11,900 | 156,000 | 0.08% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 11,694 | 154,000 | 0.08% | ||
| 50 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,858 | 143,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
