| 1 |
FMR LLC |
7,000,106 |
54,811,000 |
32.33% |
|
|
| 2 |
ORBIMED ADVISORS LLC |
5,397,698 |
42,264,000 |
24.93% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
2,059,283 |
16,124,000 |
9.51% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
1,548,033 |
12,121,000 |
7.15% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
1,251,881 |
9,802,000 |
5.78% |
|
|
| 6 |
JANUS HENDERSON INVESTORS US LLC |
1,174,537 |
9,197,000 |
5.42% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
745,801 |
5,826,000 |
3.44% |
|
|
| 8 |
PFM Health Sciences, LP |
725,169 |
5,523,000 |
3.26% |
|
|
| 9 |
Artal Group S.A. |
275,000 |
2,153,000 |
1.27% |
|
|
| 10 |
Rock Springs Capital Management LP |
271,370 |
2,125,000 |
1.25% |
|
|
| 11 |
JPMORGAN CHASE & CO |
239,000 |
1,871,000 |
1.10% |
|
|
| 12 |
Weiss Multi-Strategy Advisers LLC |
200,000 |
1,566,000 |
0.92% |
|
|
| 13 |
BlackRock Fund Advisors |
144,737 |
1,133,000 |
0.67% |
|
|
| 14 |
Asset Management One Co., Ltd. |
134,045 |
1,052,000 |
0.62% |
|
|
| 15 |
FORESITE CAPITAL MANAGEMENT III, LLC |
98,297 |
770,000 |
0.45% |
|
|
| 16 |
VANGUARD GROUP INC |
77,854 |
610,000 |
0.36% |
|
|
| 17 |
STATE STREET CORP |
65,525 |
513,000 |
0.30% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
59,064 |
462,000 |
0.27% |
|
|
| 19 |
NORTHERN TRUST CORP |
55,983 |
438,000 |
0.26% |
|
|
| 20 |
BlackRock Institutional Trust Company, N.A. |
29,152 |
228,000 |
0.13% |
|
|
| 21 |
BlackRock Investment Management, LLC |
16,775 |
131,000 |
0.08% |
|
|
| 22 |
Partner Investment Management, L.P. |
16,300 |
125,000 |
0.07% |
|
|
| 23 |
D. E. Shaw & Co., Inc. |
15,850 |
124,000 |
0.07% |
|
|
| 24 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,100 |
103,000 |
0.06% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,024 |
94,000 |
0.06% |
|
|
| 26 |
Bank of New York Mellon Corp |
10,237 |
80,000 |
0.05% |
|
|
| 27 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
7,136 |
56,000 |
0.03% |
|
|
| 28 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,700 |
52,000 |
0.03% |
|
|
| 29 |
TEACHERS ADVISORS, LLC |
5,921 |
46,000 |
0.03% |
|
|
| 30 |
CITIGROUP INC |
4,664 |
36,000 |
0.02% |
|
|
| 31 |
Nationwide Fund Advisors |
4,052 |
32,000 |
0.02% |
|
|
| 32 |
AMERICAN INTERNATIONAL GROUP, INC. |
3,200 |
25,000 |
0.01% |
|
|
| 33 |
STRS OHIO |
1,800 |
14,000 |
0.01% |
|
|
| 34 |
BLACKROCK ADVISORS LLC |
1,747 |
14,000 |
0.01% |
|
|
| 35 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,772 |
14,000 |
0.01% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
1,020 |
8,000 |
0.00% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
845 |
6,000 |
0.00% |
|
|
| 38 |
UBS Group AG |
571 |
4,000 |
0.00% |
|
|
| 39 |
MORGAN STANLEY |
179 |
1,000 |
0.00% |
|
|
| 40 |
BlackRock Finance, Inc. |
114 |
1,000 |
0.00% |
|
|
