| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,000,106 | 78,961,000 | 32.59% | ||
| 2 | ORBIMED ADVISORS LLC | 5,397,698 | 60,886,000 | 25.13% | ||
| 3 | New Leaf Venture Partners, L.L.C. | 2,059,283 | 23,229,000 | 9.59% | ||
| 4 | BAKER BROS. ADVISORS LP | 1,234,481 | 13,925,000 | 5.75% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 1,212,623 | 13,678,000 | 5.65% | ||
| 6 | RA CAPITAL MANAGEMENT, L.P. | 1,087,930 | 12,272,000 | 5.07% | ||
| 7 | PFM Health Sciences, LP | 815,359 | 8,385,000 | 3.46% | ||
| 8 | JENNISON ASSOCIATES LLC | 742,454 | 8,265,000 | 3.41% | ||
| 9 | Rock Springs Capital Management LP | 271,370 | 3,061,000 | 1.26% | ||
| 10 | DRIEHAUS CAPITAL MANAGEMENT LLC | 253,772 | 2,863,000 | 1.18% | ||
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 200,000 | 2,256,000 | 0.93% | ||
| 12 | Artal Group S.A. | 175,000 | 1,974,000 | 0.81% | ||
| 13 | Weiss Multi-Strategy Advisers LLC | 160,890 | 1,815,000 | 0.75% | ||
| 14 | JPMORGAN CHASE & CO | 158,800 | 1,792,000 | 0.74% | ||
| 15 | BlackRock Fund Advisors | 152,354 | 1,719,000 | 0.71% | ||
| 16 | Asset Management One Co., Ltd. | 134,320 | 1,516,000 | 0.63% | ||
| 17 | GOLDMAN SACHS GROUP INC | 108,945 | 1,229,000 | 0.51% | ||
| 18 | FORESITE CAPITAL MANAGEMENT III, LLC | 98,297 | 1,109,000 | 0.46% | ||
| 19 | NORTHERN TRUST CORP | 54,497 | 615,000 | 0.25% | ||
| 20 | NORGES BANK | 50,000 | 564,000 | 0.23% | ||
| 21 | STATE STREET CORP | 44,825 | 506,000 | 0.21% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 29,063 | 328,000 | 0.14% | ||
| 23 | VANGUARD GROUP INC | 26,466 | 298,000 | 0.12% | ||
| 24 | D. E. Shaw & Co., Inc. | 19,808 | 223,000 | 0.09% | ||
| 25 | Partner Investment Management, L.P. | 18,626 | 196,000 | 0.08% | ||
| 26 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,100 | 148,000 | 0.06% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,400 | 117,000 | 0.05% | ||
| 28 | BlackRock Investment Management, LLC | 8,736 | 99,000 | 0.04% | ||
| 29 | TEACHERS ADVISORS, LLC | 5,921 | 67,000 | 0.03% | ||
| 30 | Nationwide Fund Advisors | 2,789 | 31,000 | 0.01% | ||
| 31 | MORGAN STANLEY | 1,853 | 21,000 | 0.01% | ||
| 32 | STRS OHIO | 1,800 | 20,000 | 0.01% | ||
| 33 | BLACKROCK ADVISORS LLC | 1,747 | 20,000 | 0.01% | ||
| 34 | CITIGROUP INC | 1,691 | 19,000 | 0.01% | ||
| 35 | DEUTSCHE BANK AG\ | 1,408 | 15,000 | 0.01% | ||
| 36 | Tower Research Capital LLC (TRC) | 1,273 | 14,000 | 0.01% | ||
| 37 | UBS Group AG | 795 | 9,000 | 0.00% | ||
| 38 | BNP PARIBAS FINANCIAL MARKETS | 502 | 5,663 | 0.00% | ||
| 39 | Catalyst Capital Advisors LLC | 300 | 3,000 | 0.00% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 135 | 2,000 | 0.00% | ||
| 41 | WELLS FARGO & COMPANY/MN | 20 | 0 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
