| 1 |
ORBIMED ADVISORS LLC |
5,397,698 |
23,480,000 |
26.08% |
|
|
| 2 |
FMR LLC |
4,893,322 |
21,286,000 |
23.64% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
2,059,283 |
8,958,000 |
9.95% |
|
|
| 4 |
FIL Ltd |
1,688,870 |
7,347,000 |
8.16% |
|
|
| 5 |
BAKER BROS. ADVISORS LP |
1,251,881 |
5,446,000 |
6.05% |
|
|
| 6 |
JANUS HENDERSON INVESTORS US LLC |
1,106,781 |
4,815,000 |
5.35% |
|
|
| 7 |
RA CAPITAL MANAGEMENT, L.P. |
928,199 |
4,038,000 |
4.48% |
|
|
| 8 |
VANGUARD GROUP INC |
647,629 |
2,818,000 |
3.13% |
|
|
| 9 |
BlackRock Fund Advisors |
390,867 |
1,700,000 |
1.89% |
|
|
| 10 |
Weiss Multi-Strategy Advisers LLC |
365,914 |
1,592,000 |
1.77% |
|
|
| 11 |
Rock Springs Capital Management LP |
271,370 |
1,180,000 |
1.31% |
|
|
| 12 |
Artal Group S.A. |
234,493 |
1,020,000 |
1.13% |
|
|
| 13 |
STATE STREET CORP |
186,544 |
812,000 |
0.90% |
|
|
| 14 |
MILLENNIUM MANAGEMENT LLC |
175,092 |
762,000 |
0.85% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
135,950 |
591,000 |
0.66% |
|
|
| 16 |
NORTHERN TRUST CORP |
116,310 |
506,000 |
0.56% |
|
|
| 17 |
JPMORGAN CHASE & CO |
111,659 |
486,000 |
0.54% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
84,406 |
367,000 |
0.41% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
61,207 |
266,000 |
0.30% |
|
|
| 20 |
RENAISSANCE TECHNOLOGIES LLC |
54,200 |
236,000 |
0.26% |
|
|
| 21 |
Bank of New York Mellon Corp |
50,891 |
222,000 |
0.25% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
47,054 |
205,000 |
0.23% |
|
|
| 23 |
BlackRock Investment Management, LLC |
46,714 |
203,000 |
0.23% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
41,400 |
180,000 |
0.20% |
|
|
| 25 |
MORGAN STANLEY |
35,581 |
155,000 |
0.17% |
|
|
| 26 |
TURNER INVESTMENTS LLC |
30,100 |
131,000 |
0.15% |
|
|
| 27 |
RUSSELL INVESTMENTS GROUP, LTD. |
25,565 |
114,000 |
0.13% |
|
|
| 28 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25,134 |
109,000 |
0.12% |
|
|
| 29 |
Squarepoint Ops LLC |
24,370 |
106,000 |
0.12% |
|
|
| 30 |
WELLS FARGO & COMPANY/MN |
21,312 |
93,000 |
0.10% |
|
|
| 31 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
20,078 |
87,000 |
0.10% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
19,850 |
86,000 |
0.10% |
|
|
| 33 |
Nationwide Fund Advisors |
19,493 |
85,000 |
0.09% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
19,204 |
84,000 |
0.09% |
|
|
| 35 |
DEUTSCHE BANK AG\ |
17,007 |
72,000 |
0.08% |
|
|
| 36 |
TFS CAPITAL LLC |
14,043 |
61,000 |
0.07% |
|
|
| 37 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,100 |
57,000 |
0.06% |
|
|
| 38 |
CITIGROUP INC |
12,310 |
54,000 |
0.06% |
|
|
| 39 |
SG Americas Securities, LLC |
10,145 |
44,000 |
0.05% |
|
|
| 40 |
RHUMBLINE ADVISERS |
10,027 |
44,000 |
0.05% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,028 |
31,000 |
0.03% |
|
|
| 42 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,700 |
29,000 |
0.03% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
5,357 |
23,000 |
0.03% |
|
|
| 44 |
BlackRock Finance, Inc. |
5,321 |
23,000 |
0.03% |
|
|
| 45 |
UBS Group AG |
2,829 |
12,000 |
0.01% |
|
|
| 46 |
MEEDER ASSET MANAGEMENT INC |
1,971 |
9,000 |
0.01% |
|
|
| 47 |
BANK OF AMERICA CORP /DE/ |
1,679 |
7,000 |
0.01% |
|
|
| 48 |
Legal & General Group Plc |
709 |
3,000 |
0.00% |
|
|
| 49 |
ROYAL BANK OF CANADA |
704 |
3,000 |
0.00% |
|
|
| 50 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
782 |
3,000 |
0.00% |
|
|
