| 1 |
ORBIMED ADVISORS LLC |
5,397,698 |
43,128,000 |
25.31% |
|
|
| 2 |
FMR LLC |
4,893,322 |
39,098,000 |
22.94% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
2,059,283 |
16,454,000 |
9.66% |
|
|
| 4 |
FIL Ltd |
1,688,870 |
13,494,000 |
7.92% |
|
|
| 5 |
RA CAPITAL MANAGEMENT, L.P. |
1,548,033 |
12,369,000 |
7.26% |
|
|
| 6 |
BAKER BROS. ADVISORS LP |
1,251,881 |
10,003,000 |
5.87% |
|
|
| 7 |
JANUS HENDERSON INVESTORS US LLC |
1,166,913 |
9,324,000 |
5.47% |
|
|
| 8 |
VANGUARD GROUP INC |
672,683 |
5,374,000 |
3.15% |
|
|
| 9 |
PFM Health Sciences, LP |
446,003 |
3,564,000 |
2.09% |
|
|
| 10 |
BlackRock Fund Advisors |
335,013 |
2,677,000 |
1.57% |
|
|
| 11 |
Rock Springs Capital Management LP |
271,370 |
2,168,000 |
1.27% |
|
|
| 12 |
Weiss Multi-Strategy Advisers LLC |
240,000 |
1,918,000 |
1.13% |
|
|
| 13 |
Artal Group S.A. |
234,493 |
1,874,000 |
1.10% |
|
|
| 14 |
STATE STREET CORP |
135,974 |
1,087,000 |
0.64% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
135,754 |
1,084,000 |
0.64% |
|
|
| 16 |
NORTHERN TRUST CORP |
115,821 |
925,000 |
0.54% |
|
|
| 17 |
Asset Management One Co., Ltd. |
114,607 |
906,000 |
0.53% |
|
|
| 18 |
JPMORGAN CHASE & CO |
88,225 |
705,000 |
0.41% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
81,876 |
654,000 |
0.38% |
|
|
| 20 |
BlackRock Investment Management, LLC |
46,714 |
373,000 |
0.22% |
|
|
| 21 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
41,400 |
331,000 |
0.19% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
40,568 |
324,000 |
0.19% |
|
|
| 23 |
Spark Investment Management LLC |
37,800 |
302,000 |
0.18% |
|
|
| 24 |
Bank of New York Mellon Corp |
34,434 |
275,000 |
0.16% |
|
|
| 25 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
30,500 |
244,000 |
0.14% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25,934 |
207,000 |
0.12% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
20,899 |
167,000 |
0.10% |
|
|
| 28 |
TEACHERS ADVISORS, LLC |
19,204 |
153,000 |
0.09% |
|
|
| 29 |
CREDIT SUISSE AG/ |
16,488 |
132,000 |
0.08% |
|
|
| 30 |
TFS CAPITAL LLC |
15,857 |
127,000 |
0.07% |
|
|
| 31 |
D. E. Shaw & Co., Inc. |
13,297 |
106,000 |
0.06% |
|
|
| 32 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
13,100 |
105,000 |
0.06% |
|
|
| 33 |
RHUMBLINE ADVISERS |
11,775 |
94,000 |
0.06% |
|
|
| 34 |
Virtu KCG Holdings LLC |
10,392 |
83,000 |
0.05% |
|
|
| 35 |
Partner Investment Management, L.P. |
9,885 |
79,000 |
0.05% |
|
|
| 36 |
WELLS FARGO & COMPANY/MN |
9,649 |
77,000 |
0.05% |
|
|
| 37 |
TLP GROUP LLC |
8,891 |
71,000 |
0.04% |
|
|
| 38 |
Nationwide Fund Advisors |
7,468 |
60,000 |
0.04% |
|
|
| 39 |
AMERICAN INTERNATIONAL GROUP, INC. |
7,047 |
56,306 |
0.03% |
|
|
| 40 |
NEW YORK STATE COMMON RETIREMENT FUND |
6,700 |
54,000 |
0.03% |
|
|
| 41 |
BlackRock Finance, Inc. |
5,321 |
43,000 |
0.03% |
|
|
| 42 |
BLACKROCK ADVISORS LLC |
4,685 |
37,000 |
0.02% |
|
|
| 43 |
UBS Group AG |
3,109 |
25,000 |
0.01% |
|
|
| 44 |
MORGAN STANLEY |
2,233 |
18,000 |
0.01% |
|
|
| 45 |
DEUTSCHE BANK AG\ |
2,160 |
17,000 |
0.01% |
|
|
| 46 |
PRELUDE CAPITAL MANAGEMENT, LLC |
2,000 |
16,000 |
0.01% |
|
|
| 47 |
CITIGROUP INC |
997 |
8,000 |
0.00% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
782 |
6,000 |
0.00% |
|
|
| 49 |
BNP PARIBAS FINANCIAL MARKETS |
723 |
5,777 |
0.00% |
|
|
| 50 |
Tower Research Capital LLC (TRC) |
624 |
5,000 |
0.00% |
|
|
