| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 5,397,698 | 32,386,000 | 25.14% | ||
| 2 | FMR LLC | 4,893,322 | 29,360,000 | 22.79% | ||
| 3 | New Leaf Venture Partners, L.L.C. | 2,059,283 | 12,356,000 | 9.59% | ||
| 4 | FIL Ltd | 1,688,870 | 10,133,000 | 7.86% | ||
| 5 | RA CAPITAL MANAGEMENT, L.P. | 1,548,033 | 9,288,000 | 7.21% | ||
| 6 | BAKER BROS. ADVISORS LP | 1,251,881 | 7,511,000 | 5.83% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 1,177,165 | 7,063,000 | 5.48% | ||
| 8 | PFM Health Sciences, LP | 666,070 | 3,996,000 | 3.10% | ||
| 9 | VANGUARD GROUP INC | 426,165 | 2,557,000 | 1.98% | ||
| 10 | BlackRock Fund Advisors | 317,232 | 1,903,000 | 1.48% | ||
| 11 | Artal Group S.A. | 275,000 | 1,650,000 | 1.28% | ||
| 12 | Rock Springs Capital Management LP | 271,370 | 1,628,000 | 1.26% | ||
| 13 | Weiss Multi-Strategy Advisers LLC | 235,549 | 1,413,000 | 1.10% | ||
| 14 | JPMORGAN CHASE & CO | 191,875 | 1,151,000 | 0.89% | ||
| 15 | Asset Management One Co., Ltd. | 126,583 | 800,000 | 0.62% | ||
| 16 | NORTHERN TRUST CORP | 113,255 | 680,000 | 0.53% | ||
| 17 | STATE STREET CORP | 110,725 | 665,000 | 0.52% | ||
| 18 | GOLDMAN SACHS GROUP INC | 96,722 | 580,000 | 0.45% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 81,876 | 491,000 | 0.38% | ||
| 20 | Spark Investment Management LLC | 61,200 | 367,000 | 0.28% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 59,931 | 359,000 | 0.28% | ||
| 22 | BlackRock Investment Management, LLC | 46,850 | 281,000 | 0.22% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 41,653 | 250,000 | 0.19% | ||
| 24 | TFS CAPITAL LLC | 36,741 | 220,000 | 0.17% | ||
| 25 | JACOBS LEVY EQUITY MANAGEMENT, INC | 29,300 | 176,000 | 0.14% | ||
| 26 | Bank of New York Mellon Corp | 28,743 | 173,000 | 0.13% | ||
| 27 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,634 | 154,000 | 0.12% | ||
| 28 | A.R.T. Advisors, LLC | 22,497 | 134,000 | 0.10% | ||
| 29 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 21,400 | 128,000 | 0.10% | ||
| 30 | D. E. Shaw & Co., Inc. | 20,677 | 124,000 | 0.10% | ||
| 31 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 20,573 | 123,000 | 0.10% | ||
| 32 | TEACHERS ADVISORS, LLC | 19,204 | 115,000 | 0.09% | ||
| 33 | Partner Investment Management, L.P. | 14,761 | 89,000 | 0.07% | ||
| 34 | CREDIT SUISSE AG/ | 14,156 | 84,000 | 0.07% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 13,100 | 79,000 | 0.06% | ||
| 36 | Numeric Investors LLC | 12,542 | 75,000 | 0.06% | ||
| 37 | Nationwide Fund Advisors | 7,468 | 45,000 | 0.03% | ||
| 38 | AMERICAN INTERNATIONAL GROUP, INC. | 7,037 | 42,222 | 0.03% | ||
| 39 | NEW YORK STATE COMMON RETIREMENT FUND | 6,700 | 40,000 | 0.03% | ||
| 40 | MORGAN STANLEY | 6,163 | 37,000 | 0.03% | ||
| 41 | BlackRock Finance, Inc. | 5,321 | 32,000 | 0.02% | ||
| 42 | BLACKROCK ADVISORS LLC | 3,292 | 20,000 | 0.02% | ||
| 43 | PRELUDE CAPITAL MANAGEMENT, LLC | 3,000 | 18,000 | 0.01% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 1,874 | 11,000 | 0.01% | ||
| 45 | DEUTSCHE BANK AG\ | 1,873 | 11,000 | 0.01% | ||
| 46 | UBS Group AG | 1,890 | 11,000 | 0.01% | ||
| 47 | STRS OHIO | 1,800 | 10,000 | 0.01% | ||
| 48 | CITIGROUP INC | 1,241 | 7,000 | 0.01% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 782 | 5,000 | 0.00% | ||
| 50 | MUFG Americas Holdings Corp | 660 | 4,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
