| 1 |
FMR LLC |
3,762,051 |
33,708,000 |
34.93% |
|
|
| 2 |
Bain Capital Public Equity Management, LLC |
1,176,470 |
10,541,000 |
10.92% |
|
|
| 3 |
ADAGE CAPITAL PARTNERS GP, L.L.C. |
1,000,000 |
8,960,000 |
9.29% |
|
|
| 4 |
PFM Health Sciences, LP |
853,125 |
7,644,000 |
7.92% |
|
|
| 5 |
CASDIN CAPITAL, LLC |
740,000 |
6,630,000 |
6.87% |
|
|
| 6 |
BlackRock Finance, Inc. |
668,433 |
5,990,000 |
6.21% |
|
|
| 7 |
VANGUARD GROUP INC |
430,765 |
3,860,000 |
4.00% |
|
|
| 8 |
EVENTIDE ASSET MANAGEMENT, LLC |
300,000 |
2,688,000 |
2.79% |
|
|
| 9 |
DAFNA Capital Management LLC |
204,808 |
1,835,000 |
1.90% |
|
|
| 10 |
STATE STREET CORP |
184,526 |
1,653,000 |
1.71% |
|
|
| 11 |
WELLINGTON MANAGEMENT GROUP LLP |
183,237 |
1,642,000 |
1.70% |
|
|
| 12 |
PRICE T ROWE ASSOCIATES INC /MD/ |
150,384 |
1,347,000 |
1.40% |
|
|
| 13 |
NORTHERN TRUST CORP |
133,571 |
1,197,000 |
1.24% |
|
|
| 14 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
117,647 |
1,054,000 |
1.09% |
|
|
| 15 |
FIDUCIARY TRUST CO |
109,034 |
977,000 |
1.01% |
|
|
| 16 |
DIMENSIONAL FUND ADVISORS LP |
98,128 |
879,000 |
0.91% |
|
|
| 17 |
WELLS FARGO & COMPANY/MN |
91,384 |
819,000 |
0.85% |
|
|
| 18 |
GEODE CAPITAL MANAGEMENT, LLC |
68,160 |
610,000 |
0.63% |
|
|
| 19 |
Bank of New York Mellon Corp |
53,225 |
477,000 |
0.49% |
|
|
| 20 |
BESSEMER GROUP INC |
44,828 |
402,000 |
0.42% |
|
|
| 21 |
HARBOURVEST PARTNERS LLC |
44,606 |
400,000 |
0.41% |
|
|
| 22 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
37,295 |
334,000 |
0.35% |
|
|
| 23 |
PERCEPTIVE ADVISORS LLC |
34,604 |
310,000 |
0.32% |
|
|
| 24 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29,035 |
261,000 |
0.27% |
|
|
| 25 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
25,811 |
231,000 |
0.24% |
|
|
| 26 |
TEACHERS ADVISORS, LLC |
25,685 |
230,000 |
0.24% |
|
|
| 27 |
GOLDMAN SACHS GROUP INC |
17,048 |
153,000 |
0.16% |
|
|
| 28 |
Partner Investment Management, L.P. |
16,417 |
147,000 |
0.15% |
|
|
| 29 |
RHUMBLINE ADVISERS |
16,091 |
144,000 |
0.15% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
16,031 |
143,000 |
0.15% |
|
|
| 31 |
OPPENHEIMER & CO INC |
16,000 |
143,000 |
0.15% |
|
|
| 32 |
HERSHEY TRUST CO |
14,394 |
129,000 |
0.13% |
|
|
| 33 |
MORGAN STANLEY |
12,647 |
113,000 |
0.12% |
|
|
| 34 |
NEW YORK STATE COMMON RETIREMENT FUND |
12,100 |
108,000 |
0.11% |
|
|
| 35 |
RUSSELL INVESTMENTS GROUP, LTD. |
11,864 |
106,000 |
0.11% |
|
|
| 36 |
Nationwide Fund Advisors |
10,895 |
98,000 |
0.10% |
|
|
| 37 |
ALLIANCEBERNSTEIN L.P. |
10,500 |
94,000 |
0.10% |
|
|
| 38 |
RENAISSANCE TECHNOLOGIES LLC |
10,500 |
94,000 |
0.10% |
|
|
| 39 |
STATE OF WISCONSIN INVESTMENT BOARD |
10,000 |
90,000 |
0.09% |
|
|
| 40 |
BARCLAYS PLC |
9,911 |
89,000 |
0.09% |
|
|
| 41 |
AMERICAN INTERNATIONAL GROUP, INC. |
9,031 |
81,000 |
0.08% |
|
|
| 42 |
Legal & General Group Plc |
3,514 |
32,000 |
0.03% |
|
|
| 43 |
GROUP ONE TRADING LLC |
1,305 |
12,000 |
0.01% |
|
|
| 44 |
BNP PARIBAS FINANCIAL MARKETS |
1,102 |
9,874 |
0.01% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
746 |
7,000 |
0.01% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
724 |
6,000 |
0.01% |
|
|
| 47 |
Ameritas Investment Partners, Inc. |
521 |
5,000 |
0.01% |
|
|
| 48 |
GLEN EAGLE ADVISORS, LLC |
500 |
4,480 |
0.00% |
|
|
| 49 |
MEEDER ASSET MANAGEMENT INC |
194 |
2,000 |
0.00% |
|
|
| 50 |
ROYAL BANK OF CANADA |
125 |
1,000 |
0.00% |
|
|
