| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,602,403 | 73,517,000 | 21.08% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,428,569 | 68,607,000 | 19.67% | ||
| 3 | RA CAPITAL MANAGEMENT, L.P. | 2,428,571 | 68,607,000 | 19.67% | ||
| 4 | Bain Capital Public Equity Management, LLC | 1,513,400 | 42,754,000 | 12.26% | ||
| 5 | Abingworth LLP | 1,182,196 | 33,314,000 | 9.55% | ||
| 6 | FRANKLIN RESOURCES INC | 657,623 | 18,578,000 | 5.33% | ||
| 7 | JPMORGAN CHASE & CO | 263,125 | 7,433,000 | 2.13% | ||
| 8 | PRICE T ROWE ASSOCIATES INC /MD/ | 172,800 | 4,882,000 | 1.40% | ||
| 9 | Rock Springs Capital Management LP | 105,000 | 2,966,000 | 0.85% | ||
| 10 | BlackRock Fund Advisors | 96,624 | 2,730,000 | 0.78% | ||
| 11 | BLACKROCK ADVISORS LLC | 86,728 | 2,450,000 | 0.70% | ||
| 12 | AMERIPRISE FINANCIAL INC | 86,678 | 2,448,000 | 0.70% | ||
| 13 | JANUS HENDERSON INVESTORS US LLC | 79,004 | 2,232,000 | 0.64% | ||
| 14 | VANGUARD GROUP INC | 67,721 | 1,913,000 | 0.55% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 61,589 | 1,740,000 | 0.50% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 59,543 | 1,682,000 | 0.48% | ||
| 17 | SABBY MANAGEMENT, LLC | 51,510 | 1,455,000 | 0.42% | ||
| 18 | Alyeska Investment Group, L.P. | 50,000 | 1,413,000 | 0.41% | ||
| 19 | BNP Paribas Asset Management Holding S.A. | 42,794 | 1,209,000 | 0.35% | ||
| 20 | TIVERTON ASSET MANAGEMENT LLC | 40,000 | 1,130,000 | 0.32% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 34,102 | 963,000 | 0.28% | ||
| 22 | STATE STREET CORP | 28,645 | 809,000 | 0.23% | ||
| 23 | D. E. Shaw & Co., Inc. | 25,809 | 729,000 | 0.21% | ||
| 24 | MORGAN STANLEY | 25,011 | 707,000 | 0.20% | ||
| 25 | BlackRock Group LTD | 20,500 | 579,000 | 0.17% | ||
| 26 | NORTHERN TRUST CORP | 19,723 | 557,000 | 0.16% | ||
| 27 | Nationwide Fund Advisors | 18,978 | 536,000 | 0.15% | ||
| 28 | DEUTSCHE BANK AG\ | 13,158 | 371,000 | 0.11% | ||
| 29 | BlackRock Finance, Inc. | 12,600 | 356,000 | 0.10% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 11,449 | 323,000 | 0.09% | ||
| 31 | WALL STREET ASSOCIATES | 11,400 | 322,000 | 0.09% | ||
| 32 | BlackRock Investment Management, LLC | 9,844 | 278,000 | 0.08% | ||
| 33 | GOLDMAN SACHS GROUP INC | 9,079 | 256,000 | 0.07% | ||
| 34 | Bank of New York Mellon Corp | 8,356 | 236,000 | 0.07% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 6,400 | 181,000 | 0.05% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 5,400 | 153,000 | 0.04% | ||
| 37 | BANK OF AMERICA CORP /DE/ | 5,000 | 141,000 | 0.04% | ||
| 38 | TEACHERS ADVISORS, LLC | 3,560 | 101,000 | 0.03% | ||
| 39 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 3,500 | 99,000 | 0.03% | ||
| 40 | BlackRock Japan Co. Ltd | 1,498 | 42,000 | 0.01% | ||
| 41 | BARCLAYS PLC | 96 | 3,000 | 0.00% | ||
| 42 | MANAGED ACCOUNT ADVISORS LLC | 99 | 3,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
