| 1 |
FMR LLC |
2,856,911 |
16,799,000 |
23.61% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
2,428,571 |
14,280,000 |
20.07% |
|
|
| 3 |
RTW INVESTMENTS, LP |
2,026,894 |
11,918,000 |
16.75% |
|
|
| 4 |
Abingworth LLP |
945,757 |
5,561,000 |
7.82% |
|
|
| 5 |
VANGUARD GROUP INC |
487,885 |
2,869,000 |
4.03% |
|
|
| 6 |
EVENTIDE ASSET MANAGEMENT, LLC |
377,000 |
2,217,000 |
3.12% |
|
|
| 7 |
683 Capital Management, LLC |
350,000 |
2,058,000 |
2.89% |
|
|
| 8 |
BlackRock Fund Advisors |
334,603 |
1,967,000 |
2.77% |
|
|
| 9 |
RENAISSANCE TECHNOLOGIES LLC |
324,000 |
1,905,000 |
2.68% |
|
|
| 10 |
Palo Alto Investors LP |
267,890 |
1,575,000 |
2.21% |
|
|
| 11 |
UBS Group AG |
265,775 |
1,563,000 |
2.20% |
|
|
| 12 |
Omega Fund Management, LLC |
223,457 |
1,314,000 |
1.85% |
|
|
| 13 |
TIVERTON ASSET MANAGEMENT LLC |
128,926 |
758,000 |
1.07% |
|
|
| 14 |
DAFNA Capital Management LLC |
119,300 |
701,000 |
0.99% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
93,300 |
549,000 |
0.77% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
85,210 |
501,000 |
0.70% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
80,368 |
473,000 |
0.66% |
|
|
| 18 |
OXFORD ASSET MANAGEMENT LLP |
59,006 |
347,000 |
0.49% |
|
|
| 19 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
55,719 |
328,000 |
0.46% |
|
|
| 20 |
D. E. Shaw & Co., Inc. |
52,340 |
308,000 |
0.43% |
|
|
| 21 |
SABBY MANAGEMENT, LLC |
50,000 |
294,000 |
0.41% |
|
|
| 22 |
Avoro Capital Advisors LLC |
46,082 |
271,000 |
0.38% |
|
|
| 23 |
MILLENNIUM MANAGEMENT LLC |
44,322 |
261,000 |
0.37% |
|
|
| 24 |
NORTHERN TRUST CORP |
43,612 |
257,000 |
0.36% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
43,141 |
254,000 |
0.36% |
|
|
| 26 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
41,000 |
241,000 |
0.34% |
|
|
| 27 |
MORGAN STANLEY |
37,184 |
218,000 |
0.31% |
|
|
| 28 |
DIMENSIONAL FUND ADVISORS LP |
34,273 |
202,000 |
0.28% |
|
|
| 29 |
Connor, Clark & Lunn Investment Management Ltd. |
25,900 |
152,000 |
0.21% |
|
|
| 30 |
PDT Partners, LLC |
25,200 |
148,000 |
0.21% |
|
|
| 31 |
BANK OF MONTREAL /CAN/ |
22,609 |
133,000 |
0.19% |
|
|
| 32 |
DEUTSCHE BANK AG\ |
20,637 |
121,000 |
0.17% |
|
|
| 33 |
Bank of New York Mellon Corp |
16,658 |
98,000 |
0.14% |
|
|
| 34 |
BOURGEON CAPITAL MANAGEMENT LLC |
16,000 |
94,000 |
0.13% |
|
|
| 35 |
JPMORGAN CHASE & CO |
13,278 |
78,000 |
0.11% |
|
|
| 36 |
ProShare Advisors LLC |
13,089 |
77,000 |
0.11% |
|
|
| 37 |
CREDIT SUISSE AG/ |
10,245 |
60,000 |
0.08% |
|
|
| 38 |
TWIN FOCUS CAPITAL PARTNERS, LLC |
10,000 |
59,000 |
0.08% |
|
|
| 39 |
Creative Planning |
5,000 |
29,000 |
0.04% |
|
|
| 40 |
CITIGROUP INC |
4,444 |
26,000 |
0.04% |
|
|
| 41 |
BlackRock Finance, Inc. |
3,874 |
23,000 |
0.03% |
|
|
| 42 |
BlackRock Investment Management, LLC |
2,889 |
17,000 |
0.02% |
|
|
| 43 |
BLACKROCK ADVISORS LLC |
2,670 |
16,000 |
0.02% |
|
|
| 44 |
Walleye Trading LLC |
2,100 |
12,000 |
0.02% |
|
|
| 45 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
671 |
4,000 |
0.01% |
|
|
| 46 |
BANK OF AMERICA CORP /DE/ |
185 |
1,000 |
0.00% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
140 |
1,000 |
0.00% |
|
|
| 48 |
FEDERATED HERMES, INC. |
217 |
1,000 |
0.00% |
|
|
| 49 |
NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
69 |
0 |
0.00% |
|
|
