| 1 |
FMR LLC |
2,762,611 |
7,956,000 |
24.53% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
2,428,571 |
6,994,000 |
21.56% |
|
|
| 3 |
RTW INVESTMENTS, LP |
2,043,216 |
5,884,000 |
18.14% |
|
|
| 4 |
683 Capital Management, LLC |
719,450 |
2,072,000 |
6.39% |
|
|
| 5 |
RENAISSANCE TECHNOLOGIES LLC |
408,682 |
1,177,000 |
3.63% |
|
|
| 6 |
EVENTIDE ASSET MANAGEMENT, LLC |
377,000 |
1,086,000 |
3.35% |
|
|
| 7 |
Abingworth LLP |
337,825 |
973,000 |
3.00% |
|
|
| 8 |
VANGUARD GROUP INC |
324,724 |
935,000 |
2.88% |
|
|
| 9 |
UBS Group AG |
283,046 |
815,000 |
2.51% |
|
|
| 10 |
Omega Fund Management, LLC |
223,457 |
644,000 |
1.99% |
|
|
| 11 |
Palo Alto Investors LP |
158,279 |
456,000 |
1.41% |
|
|
| 12 |
Paloma Partners Management Co |
106,869 |
308,000 |
0.95% |
|
|
| 13 |
SABBY MANAGEMENT, LLC |
100,000 |
288,000 |
0.89% |
|
|
| 14 |
Anson Funds Management LP |
99,658 |
287,000 |
0.88% |
|
|
| 15 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
93,300 |
269,000 |
0.83% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
85,506 |
246,000 |
0.76% |
|
|
| 17 |
BlackRock Institutional Trust Company, N.A. |
80,368 |
231,000 |
0.71% |
|
|
| 18 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
55,319 |
159,000 |
0.49% |
|
|
| 19 |
Connor, Clark & Lunn Investment Management Ltd. |
46,100 |
133,000 |
0.41% |
|
|
| 20 |
BlackRock Fund Advisors |
44,002 |
127,000 |
0.39% |
|
|
| 21 |
BOURGEON CAPITAL MANAGEMENT LLC |
43,719 |
126,000 |
0.39% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
41,000 |
118,000 |
0.36% |
|
|
| 23 |
DEUTSCHE BANK AG\ |
41,050 |
118,000 |
0.36% |
|
|
| 24 |
MILLENNIUM MANAGEMENT LLC |
39,140 |
113,000 |
0.35% |
|
|
| 25 |
DIMENSIONAL FUND ADVISORS LP |
36,978 |
106,000 |
0.33% |
|
|
| 26 |
MORGAN STANLEY |
36,744 |
106,000 |
0.33% |
|
|
| 27 |
NORTHERN TRUST CORP |
32,851 |
94,000 |
0.29% |
|
|
| 28 |
PDT Partners, LLC |
29,300 |
84,000 |
0.26% |
|
|
| 29 |
BANK OF MONTREAL /CAN/ |
27,609 |
83,000 |
0.26% |
|
|
| 30 |
Bank of New York Mellon Corp |
28,769 |
83,000 |
0.26% |
|
|
| 31 |
TFS CAPITAL LLC |
27,704 |
80,000 |
0.25% |
|
|
| 32 |
GOLDMAN SACHS GROUP INC |
24,286 |
70,000 |
0.22% |
|
|
| 33 |
D. E. Shaw & Co., Inc. |
12,257 |
35,000 |
0.11% |
|
|
| 34 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
11,796 |
34,000 |
0.10% |
|
|
| 35 |
A.R.T. Advisors, LLC |
11,256 |
32,000 |
0.10% |
|
|
| 36 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
9,907 |
29,000 |
0.09% |
|
|
| 37 |
Tower Research Capital LLC (TRC) |
6,137 |
18,000 |
0.06% |
|
|
| 38 |
Creative Planning |
5,400 |
16,000 |
0.05% |
|
|
| 39 |
BARCLAYS PLC |
3,479 |
10,000 |
0.03% |
|
|
| 40 |
BLACKROCK ADVISORS LLC |
2,670 |
8,000 |
0.02% |
|
|
| 41 |
BlackRock Investment Management, LLC |
2,889 |
8,000 |
0.02% |
|
|
| 42 |
BlackRock Finance, Inc. |
2,257 |
7,000 |
0.02% |
|
|
| 43 |
FEDERATED HERMES, INC. |
1,541 |
4,000 |
0.01% |
|
|
| 44 |
CITIGROUP INC |
1,097 |
3,000 |
0.01% |
|
|
| 45 |
BANK OF AMERICA CORP /DE/ |
1,095 |
3,000 |
0.01% |
|
|
| 46 |
QS Investors, LLC |
1,071 |
3,000 |
0.01% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
671 |
2,000 |
0.01% |
|
|
| 48 |
PRELUDE CAPITAL MANAGEMENT, LLC |
300 |
1,000 |
0.00% |
|
|
| 49 |
BNP PARIBAS FINANCIAL MARKETS |
32 |
92 |
0.00% |
|
|
| 50 |
WELLS FARGO & COMPANY/MN |
140 |
0 |
0.00% |
|
|
