| 1 |
FMR LLC |
3,088,967 |
36,666,000 |
19.89% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
2,431,157 |
28,857,000 |
15.65% |
|
|
| 3 |
RA CAPITAL MANAGEMENT, L.P. |
2,428,571 |
28,827,000 |
15.64% |
|
|
| 4 |
RTW INVESTMENTS, LP |
1,975,229 |
23,446,000 |
12.72% |
|
|
| 5 |
Abingworth LLP |
945,757 |
11,226,000 |
6.09% |
|
|
| 6 |
BlackRock Fund Advisors |
645,510 |
7,662,000 |
4.16% |
|
|
| 7 |
VANGUARD GROUP INC |
521,226 |
6,187,000 |
3.36% |
|
|
| 8 |
EVENTIDE ASSET MANAGEMENT, LLC |
377,000 |
4,475,000 |
2.43% |
|
|
| 9 |
MILLENNIUM MANAGEMENT LLC |
292,560 |
3,473,000 |
1.88% |
|
|
| 10 |
Palo Alto Investors LP |
267,890 |
3,180,000 |
1.72% |
|
|
| 11 |
TIVERTON ASSET MANAGEMENT LLC |
250,000 |
2,968,000 |
1.61% |
|
|
| 12 |
Omega Fund Management, LLC |
223,457 |
2,652,000 |
1.44% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
190,823 |
2,265,000 |
1.23% |
|
|
| 14 |
STATE STREET CORP |
173,195 |
2,056,000 |
1.12% |
|
|
| 15 |
NORTHERN TRUST CORP |
170,468 |
2,023,000 |
1.10% |
|
|
| 16 |
MORGAN STANLEY |
144,934 |
1,721,000 |
0.93% |
|
|
| 17 |
JPMORGAN CHASE & CO |
127,625 |
1,514,000 |
0.82% |
|
|
| 18 |
DAFNA Capital Management LLC |
120,600 |
1,432,000 |
0.78% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
100,157 |
1,188,000 |
0.64% |
|
|
| 20 |
Opus Point Partners Management, LLC |
100,000 |
1,187,000 |
0.64% |
|
|
| 21 |
AQR CAPITAL MANAGEMENT LLC |
92,440 |
1,097,000 |
0.60% |
|
|
| 22 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
81,744 |
970,000 |
0.53% |
|
|
| 23 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
77,647 |
922,000 |
0.50% |
|
|
| 24 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
63,300 |
751,000 |
0.41% |
|
|
| 25 |
WELLS FARGO & COMPANY/MN |
60,382 |
717,000 |
0.39% |
|
|
| 26 |
Bank of New York Mellon Corp |
57,969 |
688,000 |
0.37% |
|
|
| 27 |
BlackRock Investment Management, LLC |
51,961 |
617,000 |
0.33% |
|
|
| 28 |
PERCEPTIVE ADVISORS LLC |
50,000 |
594,000 |
0.32% |
|
|
| 29 |
DEUTSCHE BANK AG\ |
41,598 |
493,000 |
0.27% |
|
|
| 30 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
41,000 |
487,000 |
0.26% |
|
|
| 31 |
Connor, Clark & Lunn Investment Management Ltd. |
28,500 |
338,000 |
0.18% |
|
|
| 32 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
27,990 |
332,000 |
0.18% |
|
|
| 33 |
D. E. Shaw & Co., Inc. |
23,994 |
285,000 |
0.15% |
|
|
| 34 |
TEACHERS ADVISORS, LLC |
22,080 |
262,000 |
0.14% |
|
|
| 35 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
21,814 |
259,000 |
0.14% |
|
|
| 36 |
PDT Partners, LLC |
19,833 |
235,000 |
0.13% |
|
|
| 37 |
ProShare Advisors LLC |
18,760 |
223,000 |
0.12% |
|
|
| 38 |
OXFORD ASSET MANAGEMENT LLP |
16,593 |
198,000 |
0.11% |
|
|
| 39 |
CREDIT SUISSE AG/ |
15,886 |
189,000 |
0.10% |
|
|
| 40 |
GOLDMAN SACHS GROUP INC |
15,799 |
188,000 |
0.10% |
|
|
| 41 |
Nationwide Fund Advisors |
15,620 |
185,000 |
0.10% |
|
|
| 42 |
RHUMBLINE ADVISERS |
14,463 |
172,000 |
0.09% |
|
|
| 43 |
NEW YORK STATE COMMON RETIREMENT FUND |
13,800 |
164,000 |
0.09% |
|
|
| 44 |
DIMENSIONAL FUND ADVISORS LP |
12,610 |
150,000 |
0.08% |
|
|
| 45 |
METROPOLITAN LIFE INSURANCE CO/NY |
11,866 |
141,000 |
0.08% |
|
|
| 46 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
10,205 |
121,000 |
0.07% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,847 |
105,000 |
0.06% |
|
|
| 48 |
BLACKROCK ADVISORS LLC |
7,020 |
83,000 |
0.05% |
|
|
| 49 |
PANAGORA ASSET MANAGEMENT INC |
6,819 |
81,000 |
0.04% |
|
|
| 50 |
BARCLAYS PLC |
6,688 |
73,000 |
0.04% |
|
|
