| 1 |
FMR LLC |
2,664,457 |
60,137,000 |
21.93% |
|
|
| 2 |
RA CAPITAL MANAGEMENT, L.P. |
2,428,571 |
54,813,000 |
19.99% |
|
|
| 3 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
2,428,569 |
54,813,000 |
19.99% |
|
|
| 4 |
Bain Capital Public Equity Management, LLC |
1,513,400 |
34,157,000 |
12.46% |
|
|
| 5 |
Abingworth LLP |
1,182,196 |
26,682,000 |
9.73% |
|
|
| 6 |
FRANKLIN RESOURCES INC |
734,623 |
16,580,000 |
6.05% |
|
|
| 7 |
JPMORGAN CHASE & CO |
355,575 |
8,026,000 |
2.93% |
|
|
| 8 |
SABBY MANAGEMENT, LLC |
152,994 |
3,453,000 |
1.26% |
|
|
| 9 |
VANGUARD GROUP INC |
118,085 |
2,665,000 |
0.97% |
|
|
| 10 |
BlackRock Fund Advisors |
87,901 |
1,984,000 |
0.72% |
|
|
| 11 |
EVENTIDE ASSET MANAGEMENT, LLC |
63,700 |
1,438,000 |
0.52% |
|
|
| 12 |
STATE STREET CORP |
63,452 |
1,433,000 |
0.52% |
|
|
| 13 |
BlackRock Institutional Trust Company, N.A. |
57,369 |
1,295,000 |
0.47% |
|
|
| 14 |
NORTHERN TRUST CORP |
41,690 |
941,000 |
0.34% |
|
|
| 15 |
TIVERTON ASSET MANAGEMENT LLC |
40,000 |
903,000 |
0.33% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
34,380 |
775,000 |
0.28% |
|
|
| 17 |
BLACKROCK ADVISORS LLC |
33,110 |
747,000 |
0.27% |
|
|
| 18 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
30,537 |
689,000 |
0.25% |
|
|
| 19 |
Bank of New York Mellon Corp |
23,766 |
537,000 |
0.20% |
|
|
| 20 |
Nationwide Fund Advisors |
20,481 |
462,000 |
0.17% |
|
|
| 21 |
BlackRock Investment Management, LLC |
10,760 |
243,000 |
0.09% |
|
|
| 22 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
10,528 |
238,000 |
0.09% |
|
|
| 23 |
TFS CAPITAL LLC |
10,332 |
233,000 |
0.08% |
|
|
| 24 |
MORGAN STANLEY |
8,439 |
190,000 |
0.07% |
|
|
| 25 |
UBS AG |
6,536 |
148,000 |
0.05% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
6,400 |
144,000 |
0.05% |
|
|
| 27 |
TEACHERS ADVISORS, LLC |
5,006 |
113,000 |
0.04% |
|
|
| 28 |
BANK OF AMERICA CORP /DE/ |
3,545 |
80,000 |
0.03% |
|
|
| 29 |
TOCQUEVILLE ASSET MANAGEMENT L.P. |
3,500 |
79,000 |
0.03% |
|
|
| 30 |
ALLIANCEBERNSTEIN L.P. |
2,600 |
59,000 |
0.02% |
|
|
| 31 |
AMERICAN INTERNATIONAL GROUP, INC. |
2,327 |
52,520 |
0.02% |
|
|
| 32 |
BlackRock Japan Co. Ltd |
1,498 |
34,000 |
0.01% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
990 |
22,000 |
0.01% |
|
|
| 34 |
VIRTUS CAPITAL ADVISERS, LLC |
303 |
7,000 |
0.00% |
|
|
| 35 |
WELLS FARGO & COMPANY/MN |
253 |
6,000 |
0.00% |
|
|
| 36 |
Creative Planning |
200 |
5,000 |
0.00% |
|
|
| 37 |
CITIGROUP INC |
126 |
3,000 |
0.00% |
|
|
| 38 |
BANK OF MONTREAL /CAN/ |
90 |
2,000 |
0.00% |
|
|
| 39 |
BNP PARIBAS FINANCIAL MARKETS |
73 |
1,648 |
0.00% |
|
|
| 40 |
BARCLAYS PLC |
59 |
1,000 |
0.00% |
|
|
| 41 |
Tower Research Capital LLC (TRC) |
10 |
0 |
0.00% |
|
|
