| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,359,571 | 52,548,000 | 26.51% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,984,038 | 44,185,000 | 22.29% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 661,361 | 14,729,000 | 7.43% | ||
| 4 | FRANKLIN RESOURCES INC | 598,800 | 13,335,000 | 6.73% | ||
| 5 | AMERIPRISE FINANCIAL INC | 342,429 | 7,625,000 | 3.85% | ||
| 6 | JPMORGAN CHASE & CO | 316,132 | 7,040,000 | 3.55% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 304,076 | 6,772,000 | 3.42% | ||
| 8 | JENNISON ASSOCIATES LLC | 275,278 | 6,130,000 | 3.09% | ||
| 9 | WALL STREET ASSOCIATES | 225,000 | 5,011,000 | 2.53% | ||
| 10 | BlackRock Fund Advisors | 202,850 | 4,517,000 | 2.28% | ||
| 11 | Visium Asset Management, LP | 183,625 | 4,089,000 | 2.06% | ||
| 12 | PUTNAM INVESTMENTS LLC | 163,738 | 3,646,000 | 1.84% | ||
| 13 | VANGUARD GROUP INC | 143,521 | 3,196,000 | 1.61% | ||
| 14 | STATE STREET CORP | 128,911 | 2,867,000 | 1.45% | ||
| 15 | DRIEHAUS CAPITAL MANAGEMENT LLC | 116,028 | 2,584,000 | 1.30% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 105,482 | 2,349,000 | 1.18% | ||
| 17 | Cormorant Asset Management, LP | 100,000 | 2,227,000 | 1.12% | ||
| 18 | NORTHERN TRUST CORP | 96,121 | 2,141,000 | 1.08% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 91,800 | 2,044,000 | 1.03% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 53,772 | 1,197,000 | 0.60% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 50,443 | 1,123,000 | 0.57% | ||
| 22 | SABBY MANAGEMENT, LLC | 50,000 | 1,114,000 | 0.56% | ||
| 23 | State of New Jersey Common Pension Fund D | 43,400 | 967,000 | 0.49% | ||
| 24 | MORGAN STANLEY | 40,958 | 912,000 | 0.46% | ||
| 25 | KNOTT DAVID M | 35,366 | 787,601 | 0.40% | ||
| 26 | Bank of New York Mellon Corp | 31,769 | 708,000 | 0.36% | ||
| 27 | SHEPHERD KAPLAN KROCHUK, LLC | 25,369 | 565,000 | 0.28% | ||
| 28 | BlackRock Investment Management, LLC | 23,683 | 527,000 | 0.27% | ||
| 29 | PDT Partners, LLC | 17,931 | 399,000 | 0.20% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,916 | 399,000 | 0.20% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,700 | 327,000 | 0.16% | ||
| 32 | TEACHERS ADVISORS, LLC | 11,936 | 266,000 | 0.13% | ||
| 33 | BLACKROCK ADVISORS LLC | 10,626 | 237,000 | 0.12% | ||
| 34 | D. E. Shaw & Co., Inc. | 10,435 | 232,000 | 0.12% | ||
| 35 | Nationwide Fund Advisors | 7,725 | 172,000 | 0.09% | ||
| 36 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 6,700 | 149,000 | 0.08% | ||
| 37 | Swiss National Bank | 6,000 | 134,000 | 0.07% | ||
| 38 | AMERICAN INTERNATIONAL GROUP, INC. | 5,271 | 117,385 | 0.06% | ||
| 39 | Amici Capital, LLC | 4,820 | 107,000 | 0.05% | ||
| 40 | PARADIGM ASSET MANAGEMENT CO LLC | 4,050 | 90,194 | 0.05% | ||
| 41 | BANK OF AMERICA CORP /DE/ | 3,987 | 89,000 | 0.04% | ||
| 42 | Creative Planning | 4,000 | 89,000 | 0.04% | ||
| 43 | BARCLAYS PLC | 3,921 | 86,000 | 0.04% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 3,329 | 74,000 | 0.04% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 3,000 | 67,000 | 0.03% | ||
| 46 | CITIGROUP INC | 1,797 | 41,000 | 0.02% | ||
| 47 | UBS AG | 1,774 | 40,000 | 0.02% | ||
| 48 | NOMURA HOLDINGS INC | 1,700 | 38,000 | 0.02% | ||
| 49 | DEUTSCHE BANK AG\ | 1,345 | 29,000 | 0.01% | ||
| 50 | LADENBURG THALMANN FINANCIAL SERVICES INC. | 1,000 | 22,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
