| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,449,103 | 446,112,000 | 23.83% | ||
| 2 | FMR LLC | 1,792,398 | 179,724,000 | 9.60% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 1,160,114 | 116,325,000 | 6.21% | ||
| 4 | VANGUARD GROUP INC | 882,423 | 88,481,000 | 4.73% | ||
| 5 | BlackRock Fund Advisors | 675,306 | 67,713,000 | 3.62% | ||
| 6 | FRANKLIN RESOURCES INC | 673,750 | 67,557,000 | 3.61% | ||
| 7 | JANUS HENDERSON INVESTORS US LLC | 625,683 | 62,737,000 | 3.35% | ||
| 8 | ALPINE ASSOCIATES MANAGEMENT INC. | 581,900 | 58,347,000 | 3.12% | ||
| 9 | JPMORGAN CHASE & CO | 450,734 | 45,194,000 | 2.41% | ||
| 10 | STATE STREET CORP | 443,872 | 44,503,000 | 2.38% | ||
| 11 | Redmile Group, LLC | 417,533 | 41,866,000 | 2.24% | ||
| 12 | WALL STREET ASSOCIATES | 326,332 | 32,721,000 | 1.75% | ||
| 13 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 325,000 | 32,588,000 | 1.74% | ||
| 14 | GLAZER CAPITAL, LLC | 324,517 | 32,539,000 | 1.74% | ||
| 15 | DEUTSCHE BANK AG\ | 293,254 | 29,404,000 | 1.57% | ||
| 16 | AQR ARBITRAGE LLC | 288,468 | 28,925,000 | 1.54% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 283,394 | 28,416,000 | 1.52% | ||
| 18 | DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 275,000 | 27,572,000 | 1.47% | ||
| 19 | BAMCO INC /NY/ | 250,000 | 25,067,000 | 1.34% | ||
| 20 | WEATHERBIE CAPITAL, LLC | 187,929 | 18,844,000 | 1.01% | ||
| 21 | Magnetar Financial LLC | 175,694 | 17,617,000 | 0.94% | ||
| 22 | Pentwater Capital Management LP | 150,200 | 15,061,000 | 0.80% | ||
| 23 | STIFEL FINANCIAL CORP | 139,500 | 13,988,000 | 0.75% | ||
| 24 | CHICAGO CAPITAL MANAGEMENT, LLC | 136,827 | 13,720,000 | 0.73% | ||
| 25 | KNOTT DAVID M | 128,500 | 12,884,695 | 0.69% | ||
| 26 | NORTHERN TRUST CORP | 126,778 | 12,712,000 | 0.68% | ||
| 27 | SPHERA FUNDS MANAGEMENT LTD. | 125,074 | 12,541,000 | 0.67% | ||
| 28 | BANK OF MONTREAL /CAN/ | 125,000 | 12,534,000 | 0.67% | ||
| 29 | ARROWGRASS CAPITAL PARTNERS (US) LP | 124,752 | 12,509,000 | 0.67% | ||
| 30 | COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS | 123,762 | 12,410,000 | 0.66% | ||
| 31 | DAFNA Capital Management LLC | 120,500 | 12,083,000 | 0.65% | SH | |
| 32 | ORBIMED ADVISORS LLC | 118,600 | 11,892,000 | 0.64% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 106,924 | 10,721,000 | 0.57% | ||
| 34 | Parallax Volatility Advisers, L.P. | 100,000 | 10,027,000 | 0.54% | Call | |
| 35 | PUTNAM INVESTMENTS LLC | 99,838 | 10,011,000 | 0.53% | ||
| 36 | AMERIPRISE FINANCIAL INC | 94,547 | 9,480,000 | 0.51% | ||
| 37 | Asset Management One Co., Ltd. | 91,394 | 9,172,000 | 0.49% | ||
| 38 | GARDNER LEWIS ASSET MANAGEMENT L P | 88,800 | 8,904,000 | 0.48% | ||
| 39 | Bank of New York Mellon Corp | 87,615 | 8,785,000 | 0.47% | ||
| 40 | Foresite Capital Management II, LLC | 75,000 | 7,520,000 | 0.40% | ||
| 41 | GABELLI FUNDS LLC | 69,300 | 6,949,000 | 0.37% | ||
| 42 | DRIEHAUS CAPITAL MANAGEMENT LLC | 69,085 | 6,927,000 | 0.37% | ||
| 43 | LAZARD ASSET MANAGEMENT LLC | 64,135 | 6,430,000 | 0.34% | ||
| 44 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 62,490 | 6,266,000 | 0.33% | ||
| 45 | Endurant Capital Management LP | 59,250 | 5,941,000 | 0.32% | ||
| 46 | BTG Pactual Global Asset Management Ltd | 55,300 | 5,545,000 | 0.30% | ||
| 47 | APIS CAPITAL ADVISORS, LLC | 69,460 | 5,465,000 | 0.29% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 52,449 | 5,259,000 | 0.28% | ||
| 49 | OMERS ADMINISTRATION Corp | 48,700 | 4,883,000 | 0.26% | ||
| 50 | State of New Jersey Common Pension Fund D | 43,400 | 4,352,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
