| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,072,075 | 213,702,000 | 27.53% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,949,103 | 154,769,000 | 19.94% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 1,038,734 | 54,513,000 | 7.02% | ||
| 4 | FRANKLIN RESOURCES INC | 638,657 | 33,517,000 | 4.32% | ||
| 5 | BlackRock Fund Advisors | 582,766 | 30,584,000 | 3.94% | ||
| 6 | JENNISON ASSOCIATES LLC | 560,812 | 29,431,000 | 3.79% | ||
| 7 | VANGUARD GROUP INC | 432,338 | 22,690,000 | 2.92% | ||
| 8 | WALL STREET ASSOCIATES | 432,100 | 22,677,000 | 2.92% | ||
| 9 | BANK OF MONTREAL /CAN/ | 425,000 | 22,304,000 | 2.87% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 401,200 | 21,055,000 | 2.71% | ||
| 11 | JPMORGAN CHASE & CO | 285,375 | 14,976,000 | 1.93% | ||
| 12 | Bank of New York Mellon Corp | 207,477 | 10,888,000 | 1.40% | ||
| 13 | AMERIPRISE FINANCIAL INC | 184,211 | 9,667,000 | 1.25% | ||
| 14 | Foresite Capital Management II, LLC | 171,824 | 9,017,000 | 1.16% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 138,480 | 7,267,000 | 0.94% | ||
| 16 | DAFNA Capital Management LLC | 135,885 | 7,131,000 | 0.92% | ||
| 17 | KNOTT DAVID M | 128,500 | 6,743,680 | 0.87% | ||
| 18 | STATE STREET CORP | 122,261 | 6,412,000 | 0.83% | ||
| 19 | LAZARD ASSET MANAGEMENT LLC | 116,860 | 6,132,000 | 0.79% | ||
| 20 | SPHERA FUNDS MANAGEMENT LTD. | 110,074 | 5,777,000 | 0.74% | ||
| 21 | NORTHERN TRUST CORP | 104,004 | 5,457,000 | 0.70% | ||
| 22 | Broadfin Capital, LLC | 100,000 | 5,248,000 | 0.68% | ||
| 23 | Cormorant Asset Management, LP | 100,000 | 5,248,000 | 0.68% | ||
| 24 | PUTNAM INVESTMENTS LLC | 99,838 | 5,239,000 | 0.68% | ||
| 25 | C WorldWide Group Holding A/S | 97,921 | 5,139,000 | 0.66% | ||
| 26 | ORBIMED ADVISORS LLC | 93,600 | 4,912,000 | 0.63% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 74,312 | 3,899,000 | 0.50% | ||
| 28 | DRIEHAUS CAPITAL MANAGEMENT LLC | 68,678 | 3,604,000 | 0.46% | ||
| 29 | APIS CAPITAL ADVISORS, LLC | 65,000 | 3,412,000 | 0.44% | ||
| 30 | Endurant Capital Management LP | 53,950 | 2,831,000 | 0.36% | ||
| 31 | SABBY MANAGEMENT, LLC | 50,000 | 2,624,000 | 0.34% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,841 | 2,616,000 | 0.34% | ||
| 33 | State of New Jersey Common Pension Fund D | 43,400 | 2,278,000 | 0.29% | ||
| 34 | PRICE T ROWE ASSOCIATES INC /MD/ | 40,359 | 2,118,000 | 0.27% | ||
| 35 | Granite Point Capital Management, L.P. | 36,000 | 1,889,000 | 0.24% | ||
| 36 | CREDIT SUISSE AG/ | 31,426 | 1,649,000 | 0.21% | ||
| 37 | SHEPHERD KAPLAN KROCHUK, LLC | 28,149 | 1,477,000 | 0.19% | ||
| 38 | BlackRock Investment Management, LLC | 26,970 | 1,415,000 | 0.18% | ||
| 39 | Birchview Capital, LP | 25,500 | 1,338,000 | 0.17% | ||
| 40 | Forward Management, LLC | 54,476 | 1,288,000 | 0.17% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 24,000 | 1,260,000 | 0.16% | ||
| 42 | D. E. Shaw & Co., Inc. | 21,737 | 1,141,000 | 0.15% | ||
| 43 | Invesco Ltd. | 21,071 | 1,106,000 | 0.14% | ||
| 44 | ProShare Advisors LLC | 20,263 | 1,063,000 | 0.14% | ||
| 45 | Knoll Capital Management, LLC | 20,000 | 1,050,000 | 0.14% | ||
| 46 | Ghost Tree Capital, LLC | 20,000 | 1,050,000 | 0.14% | ||
| 47 | DEUTSCHE BANK AG\ | 19,455 | 1,020,000 | 0.13% | ||
| 48 | MORGAN STANLEY | 18,371 | 964,000 | 0.12% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,257 | 906,000 | 0.12% | ||
| 50 | STATE OF MICHIGAN RETIREMENT SYSTEM | 16,997 | 892,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
