| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 2,619,571 | 67,244,000 | 21.45% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,512,160 | 64,487,000 | 20.57% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 1,167,255 | 29,963,000 | 9.56% | ||
| 4 | FRANKLIN RESOURCES INC | 674,550 | 17,316,000 | 5.52% | ||
| 5 | AMERIPRISE FINANCIAL INC | 441,847 | 11,343,000 | 3.62% | ||
| 6 | WALL STREET ASSOCIATES | 435,000 | 11,166,000 | 3.56% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 423,879 | 10,872,000 | 3.47% | ||
| 8 | VANGUARD GROUP INC | 362,831 | 9,313,000 | 2.97% | ||
| 9 | JPMORGAN CHASE & CO | 314,607 | 8,076,000 | 2.58% | ||
| 10 | JENNISON ASSOCIATES LLC | 255,313 | 6,554,000 | 2.09% | ||
| 11 | BlackRock Fund Advisors | 221,096 | 5,676,000 | 1.81% | ||
| 12 | Visium Asset Management, LP | 183,625 | 4,714,000 | 1.50% | ||
| 13 | SPHERA FUNDS MANAGEMENT LTD. | 165,074 | 4,237,000 | 1.35% | ||
| 14 | PUTNAM INVESTMENTS LLC | 163,738 | 4,203,000 | 1.34% | ||
| 15 | STATE STREET CORP | 153,539 | 3,938,000 | 1.26% | ||
| 16 | DAFNA Capital Management LLC | 152,002 | 3,902,000 | 1.24% | SH | |
| 17 | BANK OF MONTREAL /CAN/ | 130,861 | 3,359,000 | 1.07% | ||
| 18 | Bank of New York Mellon Corp | 130,010 | 3,338,000 | 1.06% | ||
| 19 | KNOTT DAVID M | 128,500 | 3,298,595 | 1.05% | ||
| 20 | SABBY MANAGEMENT, LLC | 120,000 | 3,080,000 | 0.98% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 114,624 | 2,942,000 | 0.94% | ||
| 22 | EMERALD ADVISERS, LLC | 109,230 | 2,804,000 | 0.89% | ||
| 23 | NORTHERN TRUST CORP | 106,790 | 2,742,000 | 0.87% | ||
| 24 | EMERALD MUTUAL FUND ADVISERS TRUST | 102,010 | 2,619,000 | 0.84% | ||
| 25 | PERCEPTIVE ADVISORS LLC | 100,000 | 2,567,000 | 0.82% | ||
| 26 | Cormorant Asset Management, LP | 100,000 | 2,567,000 | 0.82% | ||
| 27 | Iguana Healthcare Management, LLC | 90,000 | 2,310,000 | 0.74% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 73,011 | 1,874,000 | 0.60% | ||
| 29 | DRIEHAUS CAPITAL MANAGEMENT LLC | 66,740 | 1,713,000 | 0.55% | ||
| 30 | J. Goldman & Co LP | 52,500 | 1,348,000 | 0.43% | ||
| 31 | Lombard Odier Asset Management (USA) Corp | 51,400 | 1,319,000 | 0.42% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,081 | 1,260,000 | 0.40% | ||
| 33 | State of New Jersey Common Pension Fund D | 43,400 | 1,114,000 | 0.36% | ||
| 34 | GREEN ARROW CAPITAL MANAGEMENT LLC | 40,000 | 1,027,000 | 0.33% | ||
| 35 | Granite Point Capital Management, L.P. | 40,000 | 1,027,000 | 0.33% | ||
| 36 | Alyeska Investment Group, L.P. | 34,856 | 895,000 | 0.29% | ||
| 37 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 34,316 | 881,000 | 0.28% | ||
| 38 | SHEPHERD KAPLAN KROCHUK, LLC | 28,149 | 723,000 | 0.23% | ||
| 39 | BlackRock Investment Management, LLC | 27,075 | 695,000 | 0.22% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,146 | 595,000 | 0.19% | ||
| 41 | TFS CAPITAL LLC | 18,437 | 473,000 | 0.15% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 17,184 | 441,000 | 0.14% | ||
| 43 | BLUE ARROW CAPITAL MANAGEMENT LLC | 15,000 | 385,000 | 0.12% | ||
| 44 | BLACKROCK ADVISORS LLC | 12,349 | 317,000 | 0.10% | ||
| 45 | Paloma Partners Management Co | 11,790 | 303,000 | 0.10% | ||
| 46 | DEUTSCHE BANK AG\ | 10,548 | 270,000 | 0.09% | ||
| 47 | Swiss National Bank | 10,300 | 264,000 | 0.08% | ||
| 48 | TEACHERS ADVISORS, LLC | 9,456 | 243,000 | 0.08% | ||
| 49 | CREDIT SUISSE AG/ | 9,211 | 237,000 | 0.08% | ||
| 50 | Nationwide Fund Advisors | 8,693 | 223,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
