| 1 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,264,588 |
30,654,000 |
20.55% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
2,236,218 |
20,998,000 |
14.08% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
1,300,000 |
12,207,000 |
8.19% |
|
|
| 4 |
BlackRock Fund Advisors |
1,123,162 |
10,546,000 |
7.07% |
|
|
| 5 |
VANGUARD GROUP INC |
846,341 |
7,947,000 |
5.33% |
|
|
| 6 |
ROYCE & ASSOCIATES LP |
594,295 |
5,580,000 |
3.74% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
515,004 |
4,836,000 |
3.24% |
|
|
| 8 |
CANNELL CAPITAL LLC |
484,539 |
4,550,000 |
3.05% |
|
|
| 9 |
Redmile Group, LLC |
421,742 |
3,960,000 |
2.66% |
|
|
| 10 |
RENAISSANCE TECHNOLOGIES LLC |
410,800 |
3,857,000 |
2.59% |
|
|
| 11 |
DIMENSIONAL FUND ADVISORS LP |
376,113 |
3,532,000 |
2.37% |
|
|
| 12 |
DESTRIER CAPITAL MANAGEMENT LLC |
349,108 |
3,278,000 |
2.20% |
|
|
| 13 |
STATE STREET CORP |
325,378 |
3,059,000 |
2.05% |
|
|
| 14 |
FULLER & THALER ASSET MANAGEMENT, INC. |
305,441 |
2,868,000 |
1.92% |
|
|
| 15 |
NORTHERN TRUST CORP |
291,793 |
2,740,000 |
1.84% |
|
|
| 16 |
AMERIPRISE FINANCIAL INC |
197,498 |
1,854,000 |
1.24% |
|
|
| 17 |
Bank of New York Mellon Corp |
166,742 |
1,565,000 |
1.05% |
|
|
| 18 |
MORGAN STANLEY |
164,016 |
1,541,000 |
1.03% |
|
|
| 19 |
Granite Investment Partners, LLC |
160,632 |
1,509,000 |
1.01% |
|
|
| 20 |
MILLENNIUM MANAGEMENT LLC |
155,841 |
1,463,000 |
0.98% |
|
|
| 21 |
Spark Investment Management LLC |
143,700 |
1,349,000 |
0.90% |
|
|
| 22 |
PARAMETRIC PORTFOLIO ASSOCIATES LLC |
138,175 |
1,297,000 |
0.87% |
|
|
| 23 |
OXFORD ASSET MANAGEMENT LLP |
133,437 |
1,253,000 |
0.84% |
|
|
| 24 |
GEODE CAPITAL MANAGEMENT, LLC |
132,892 |
1,247,000 |
0.84% |
|
|
| 25 |
PRINCIPAL FINANCIAL GROUP INC |
114,149 |
1,072,000 |
0.72% |
|
|
| 26 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
108,100 |
1,015,000 |
0.68% |
|
|
| 27 |
CONTINENTAL ADVISORS LLC |
104,488 |
981,000 |
0.66% |
|
|
| 28 |
Glacier Peak Capital LLC |
92,964 |
873,000 |
0.59% |
|
|
| 29 |
Cowen Prime Services LLC |
80,000 |
751,000 |
0.50% |
|
|
| 30 |
GSA CAPITAL PARTNERS LLP |
75,628 |
710,000 |
0.48% |
|
|
| 31 |
KENNEDY CAPITAL MANAGEMENT LLC |
73,353 |
689,000 |
0.46% |
|
|
| 32 |
BlackRock Investment Management, LLC |
70,814 |
665,000 |
0.45% |
|
|
| 33 |
NEW YORK STATE TEACHERS RETIREMENT SYSTEM |
59,525 |
559,000 |
0.37% |
|
|
| 34 |
NORGES BANK |
55,000 |
516,000 |
0.35% |
|
|
| 35 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
45,000 |
423,000 |
0.28% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
45,011 |
423,000 |
0.28% |
|
|
| 37 |
TWO SIGMA INVESTMENTS, LP |
44,618 |
419,000 |
0.28% |
|
|
| 38 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
43,007 |
404,000 |
0.27% |
|
|
| 39 |
PRUDENTIAL FINANCIAL INC |
38,925 |
366,000 |
0.25% |
|
|
| 40 |
TFS CAPITAL LLC |
38,894 |
365,000 |
0.24% |
|
|
| 41 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
37,951 |
356,000 |
0.24% |
|
|
| 42 |
Invesco Ltd. |
37,315 |
350,000 |
0.23% |
|
|
| 43 |
DEUTSCHE BANK AG\ |
31,791 |
298,000 |
0.20% |
|
|
| 44 |
ROYAL BANK OF CANADA |
31,200 |
293,000 |
0.20% |
|
|
| 45 |
TWO SIGMA ADVISERS, LP |
28,306 |
266,000 |
0.18% |
|
|
| 46 |
NEW YORK STATE COMMON RETIREMENT FUND |
22,300 |
209,000 |
0.14% |
|
|
| 47 |
A.R.T. Advisors, LLC |
21,475 |
201,000 |
0.13% |
|
|
| 48 |
RHUMBLINE ADVISERS |
20,804 |
195,000 |
0.13% |
|
|
| 49 |
TEACHERS ADVISORS, LLC |
18,842 |
177,000 |
0.12% |
|
|
| 50 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
18,181 |
171,000 |
0.11% |
|
|
