| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,640,609 | 37,021,000 | 15.31% | ||
| 2 | WELLINGTON MANAGEMENT GROUP LLP | 2,242,770 | 31,444,000 | 13.00% | ||
| 3 | ORBIMED ADVISORS LLC | 1,300,000 | 18,226,000 | 7.54% | ||
| 4 | BlackRock Fund Advisors | 1,159,866 | 16,261,000 | 6.72% | ||
| 5 | RIVERHEAD CAPITAL MANAGEMENT LLC | 163,701 | 12,401,000 | 5.13% | ||
| 6 | VANGUARD GROUP INC | 838,830 | 11,760,000 | 4.86% | ||
| 7 | ROYCE & ASSOCIATES LP | 787,257 | 11,037,000 | 4.56% | ||
| 8 | RENAISSANCE TECHNOLOGIES LLC | 685,700 | 9,614,000 | 3.97% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 520,546 | 7,298,000 | 3.02% | ||
| 10 | DIMENSIONAL FUND ADVISORS LP | 431,428 | 6,049,000 | 2.50% | ||
| 11 | Redmile Group, LLC | 426,242 | 5,976,000 | 2.47% | ||
| 12 | STATE STREET CORP | 319,159 | 4,474,000 | 1.85% | ||
| 13 | FULLER & THALER ASSET MANAGEMENT, INC. | 309,741 | 4,343,000 | 1.80% | ||
| 14 | NORTHERN TRUST CORP | 287,778 | 4,034,000 | 1.67% | ||
| 15 | Cowen Prime Services LLC | 257,300 | 3,607,000 | 1.49% | ||
| 16 | OXFORD ASSET MANAGEMENT LLP | 245,440 | 3,441,000 | 1.42% | ||
| 17 | Bank of New York Mellon Corp | 186,299 | 2,613,000 | 1.08% | ||
| 18 | Informed Momentum Co LLC | 177,930 | 2,495,000 | 1.03% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 174,560 | 2,446,000 | 1.01% | ||
| 20 | DEUTSCHE BANK AG\ | 146,359 | 2,050,000 | 0.85% | ||
| 21 | MORGAN STANLEY | 144,943 | 2,033,000 | 0.84% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 144,393 | 2,024,000 | 0.84% | ||
| 23 | Spark Investment Management LLC | 143,700 | 2,014,000 | 0.83% | ||
| 24 | TWO SIGMA INVESTMENTS, LP | 129,160 | 1,811,000 | 0.75% | ||
| 25 | TWO SIGMA ADVISERS, LP | 126,706 | 1,776,000 | 0.73% | ||
| 26 | PRINCIPAL FINANCIAL GROUP INC | 117,876 | 1,653,000 | 0.68% | ||
| 27 | MCKINLEY CAPITAL MANAGEMENT LLC | 112,715 | 1,580,000 | 0.65% | ||
| 28 | GSA CAPITAL PARTNERS LLP | 111,450 | 1,563,000 | 0.65% | ||
| 29 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 110,929 | 1,555,000 | 0.64% | ||
| 30 | Granite Investment Partners, LLC | 100,415 | 1,407,000 | 0.58% | ||
| 31 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 98,600 | 1,382,000 | 0.57% | ||
| 32 | Jefferies Group LLC | 92,100 | 1,291,000 | 0.53% | Call | |
| 33 | CONTINENTAL ADVISORS LLC | 91,800 | 1,287,000 | 0.53% | ||
| 34 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 88,000 | 1,234,000 | 0.51% | ||
| 35 | JACOBS LEVY EQUITY MANAGEMENT, INC | 82,510 | 1,157,000 | 0.48% | ||
| 36 | AMERIPRISE FINANCIAL INC | 80,078 | 1,122,000 | 0.46% | ||
| 37 | Glacier Peak Capital LLC | 75,900 | 1,064,000 | 0.44% | ||
| 38 | BlackRock Investment Management, LLC | 75,561 | 1,059,000 | 0.44% | ||
| 39 | CREDIT SUISSE AG/ | 61,922 | 868,000 | 0.36% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 59,673 | 837,000 | 0.35% | ||
| 41 | NEW YORK STATE TEACHERS RETIREMENT SYSTEM | 58,625 | 822,000 | 0.34% | ||
| 42 | Allianz Asset Management GmbH | 56,295 | 789,000 | 0.33% | ||
| 43 | DEERE & CO | 52,839 | 741,000 | 0.31% | ||
| 44 | Numeric Investors LLC | 47,900 | 672,000 | 0.28% | ||
| 45 | EMERALD ACQUISITION LTD. | 47,088 | 660,000 | 0.27% | ||
| 46 | ROYAL BANK OF CANADA | 46,206 | 648,000 | 0.27% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 45,725 | 642,000 | 0.27% | ||
| 48 | PRUDENTIAL FINANCIAL INC | 39,845 | 559,000 | 0.23% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,851 | 531,000 | 0.22% | ||
| 50 | Invesco Ltd. | 36,240 | 508,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
